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Stock-based compensation (Tables)
 6 Months Ended
Jun. 30, 2021
Share-based Payment Arrangement [Abstract]  
Summary of Stock-Based Compensation Expense by Award Type Stock-based compensation expense by award type included within the condensed consolidated statements of operations and comprehensive loss was as follows (in thousands):
For the three months ended June 30,For the six months ended June 30,

2021202020212020
Stock options
$17,324 $26,073 $37,983 $50,513 
Restricted stock units
8,534 14,143 23,267 25,996 
Employee stock purchase plan and other5,193 8,313 12,275 8,313 
$31,051 $48,529 $73,525 $84,822 
Schedule of Stock-Based Compensation Expense by Classification Stock-based compensation expense by classification included within the condensed consolidated statements of operations and comprehensive loss was as follows (in thousands): 
For the three months ended June 30,For the six months ended June 30,
2021202020212020
Research and development$15,768 $23,098 $35,636 $39,367 
Selling, general and administrative15,283 25,431 37,889 45,455 
$31,051 $48,529 $73,525 $84,822 
Summary of Stock Option Activity Under Plan The following table summarizes the stock option activity under the Company’s equity award plans:
Shares
(in thousands)
Weighted-
average
exercise price
per share
Outstanding at December 31, 20206,262 $105.02 
Granted
811 $29.52 
Exercised
(209)$6.02 
Canceled, forfeited, or expired
(765)$108.51 
Outstanding at June 30, 20216,099 $97.93 
Exercisable at June 30, 20213,854 $110.83 
Vested and expected to vest at June 30, 20216,099 $97.93 
Summary of Restricted Common Stock Awards The following table summarizes the restricted stock unit activity under the Company’s equity award plans:
Shares
(in thousands)		Weighted-
average
grant date
fair value
Unvested balance at December 31, 20201,495 $102.34 
Granted
1,128 $21.38 
Vested
(421)$59.35 
Forfeited
(337)$77.19 
Unvested balance at June 30, 20211,865 $59.02