The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACADIA PHARMACEUTICALS INC COM 004225108 6,431 187,055 SH   DFND   187,055 0 0
ACCELERON PHARMA INC COM 00434H108 12,717 480,437 SH   DFND   480,437 0 0
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107 6,940 1,360,647 SH   DFND   1,360,647 0 0
AGENUS INC COM NEW 00847G705 15,451 4,098,534 SH   DFND   4,098,534 0 0
AKARI THERAPEUTICS PLC SPONSORED ADR 00972G108 1,887 209,121 SH   DFND   209,121 0 0
ALLERGAN PLC PFD CONV SER A G0177J116 42,377 50,000 SH   DFND   50,000 0 0
ALLIANCE DATA SYSTEMS CORP COM 018581108 21,106 84,765 SH   DFND   84,765 0 0
AMBARELLA INC SHS G037AX101 15,733 287,577 SH   DFND   287,577 0 0
ANTERO RES CORP COM 03674X106 8,518 373,413 SH   DFND   373,413 0 0
ANTHEM INC NOTE 2.750%10/1 94973VBG1 37,914 16,500,000 PRN   DFND   16,500,000 0 0
ARBUTUS BIOPHARMA CORP COM 03879J100 52,044 16,013,540 SH   DFND   0 16,013,540 0
ARROWHEAD PHARMACEUTICALS IN COM 04280A100 4,729 2,556,256 SH   DFND   2,556,256 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 15,649 694,817 SH   DFND   694,817 0 0
AVEXIS INC COM 05366U100 16,754 220,356 SH   DFND   220,356 0 0
AXOVANT SCIENCES LTD COM G0750W104 1,120,500 75,000,000 SH   DFND   0 75,000,000 0
BEIGENE LTD SPONSORED ADR 07725L102 6,224 170,000 SH   DFND   170,000 0 0
BELLICUM PHARMACEUTICALS INC COM 079481107 3,711 300,723 SH   DFND   300,723 0 0
BIOGEN INC COM 09062X103 3,215 11,760 SH   DFND   11,760 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 5,137 58,517 SH   DFND   58,517 0 0
BIOVERATIV INC COM 09075E100 320 5,879 SH   DFND   5,879 0 0
BLUEBIRD BIO INC COM 09609G100 7,183 79,016 SH   DFND   79,016 0 0
CABOT OIL & GAS CORP COM 127097103 13,010 544,142 SH   DFND   544,142 0 0
CAL MAINE FOODS INC COM NEW 128030202 9,388 255,100 SH   DFND   255,100 0 0
CARMAX INC COM 143130102 24,285 410,089 SH   DFND   410,089 0 0
CASCADIAN THERAPEUTICS INC COM NEW 14740B606 3,312 800,000 SH   DFND   800,000 0 0
CTRIP COM INTL LTD NOTE 1.250%10/1 22943FAD2 32,323 24,500,000 PRN   DFND   24,500,000 0 0
CTRIP COM INTL LTD NOTE 1.000% 7/0 22943FAF7 14,066 12,650,000 PRN   DFND   12,650,000 0 0
DHT HOLDINGS INC SHS NEW Y2065G121 5,391 1,206,051 SH   DFND   1,206,051 0 0
DHT HOLDINGS INC DEBT 4.500%10/0 23335SAB2 11,190 11,440,000 PRN   DFND   11,440,000 0 0
EPIZYME INC COM 29428V104 6,096 355,445 SH   DFND   355,445 0 0
EQUITY COMWLTH COM SH BEN INT 294628102 17,317 554,688 SH   DFND   554,688 0 0
EURONAV NV ANTWERPEN SHS B38564108 10,672 1,350,924 SH   DFND   1,350,924 0 0
GOLDMAN SACHS GROUP INC COM 38141G104 18,823 81,940 SH   DFND   81,940 0 0
GRAY TELEVISION INC COM 389375106 10,693 737,454 SH   DFND   737,454 0 0
GULFMARK OFFSHORE INC CL A NEW 402629208 213 607,500 SH   DFND   607,500 0 0
HERBALIFE LTD NOTE 2.000% 8/1 42703MAB9 24,030 25,000,000 PRN   DFND   25,000,000 0 0
HOME DEPOT INC COM 437076102 11,306 77,000 SH   DFND   77,000 0 0
HUNTER MARITIME ACQUISITION UNIT 99/99/9999 Y37828103 10,400 1,000,000 SH   DFND   1,000,000 0 0
IKANG HEALTHCARE GROUP INC SPONSORED ADR 45174L108 22,788 1,560,843 SH   DFND   1,560,843 0 0
INTEL CORP SDCV 12/1 458140AD2 82,656 60,247,000 PRN   DFND   60,247,000 0 0
INTEL CORP COM 458140100 21,184 587,314 SH   DFND   587,314 0 0
INTERCEPT PHARMACEUTICALS IN COM 45845P108 6,263 55,380 SH   DFND   55,380 0 0
INTERNATIONAL SEAWAYS INC COM Y41053102 350 18,309 SH   DFND   18,309 0 0
ISHARES TR NASDQ BIOTEC ETF 464287556 68,081 232,145 SH   DFND   232,145 0 0
ISHARES TR U.S. PFD STK ETF 464288687 1,981 51,194 SH   DFND   51,194 0 0
ISHARES TR IBOXX HI YD ETF 464288513 1,581 18,014 SH   DFND   18,014 0 0
JPMORGAN CHASE & CO COM 46625H100 9,661 109,985 SH   DFND   109,985 0 0
LION BIOTECHNOLOGIES INC COM 53619R102 10,019 1,385,309 SH   DFND   1,385,309 0 0
MAKEMYTRIP LIMITED MAURITIUS SHS V5633W109 68,951 2,053,014 SH   DFND   2,053,014 0 0
MICROCHIP TECHNOLOGY INC SDCV 2.125%12/1 595017AB0 21,032 6,752,000 PRN   DFND   6,752,000 0 0
MYOVANT SCIENCES LTD COM G637AM102 437,096 37,231,342 SH   DFND   0 37,231,342 0
NEW YORK TIMES CO CL A 650111107 26,594 1,846,822 SH   DFND   1,846,822 0 0
NORDIC AMERICAN TANKERS LIMI COM G65773106 6,595 806,200 SH Put DFND   806,200 0 0
NORTHSTAR REALTY EUROPE CORP COM 66706L101 18,764 1,664,363 SH   DFND   1,664,363 0 0
NOVELLUS SYS INC NOTE 2.625% 5/1 670008AD3 5,973 1,570,000 PRN   DFND   1,570,000 0 0
NXP SEMICONDUCTORS N V DBCV 1.000%12/0 62952QAB6 11,601 10,000,000 PRN   DFND   10,000,000 0 0
PALATIN TECHNOLOGIES INC COM PAR $ .01 696077403 985 4,296,847 SH   DFND   4,296,847 0 0
PAYPAL HLDGS INC COM 70450Y103 17,319 402,573 SH   DFND   402,573 0 0
PDVWIRELESS INC COM 69290R104 16,931 894,031 SH   DFND   894,031 0 0
PRICELINE GRP INC NOTE 1.000% 3/1 741503AQ9 5,426 2,880,000 PRN   DFND   2,880,000 0 0
REGENXBIO INC COM 75901B107 3,733 193,432 SH   DFND   193,432 0 0
RICE ENERGY INC COM 762760106 11,217 473,300 SH   DFND   473,300 0 0
SAREPTA THERAPEUTICS INC COM 803607100 6,562 221,691 SH   DFND   221,691 0 0
SHIP FINANCE INTERNATIONAL L NOTE 3.250% 2/0 G81075AE6 43,486 39,986,000 PRN   DFND   39,986,000 0 0
SINCLAIR BROADCAST GROUP INC CL A 829226109 16,079 397,023 SH   DFND   397,023 0 0
SPDR SERIES TRUST S&P BIOTECH 78464A870 404,231 5,829,700 SH Put DFND   5,829,700 0 0
SPDR SERIES TRUST S&P RETAIL ETF 78464A714 6,444 152,557 SH   DFND   152,557 0 0
SPDR SERIES TRUST S&P REGL BKG 78464A698 3,358 61,491 SH   DFND   61,491 0 0
TAL ED GROUP NOTE 2.500% 5/1 874080AB0 117,703 29,000,000 PRN   DFND   29,000,000 0 0
TEEKAY TANKERS LTD CL A Y8565N102 6,648 3,243,074 SH   DFND   3,243,074 0 0
TESARO INC COM 881569107 5,567 36,179 SH   DFND   36,179 0 0
TIME WARNER INC COM NEW 887317303 15,782 161,518 SH   DFND   161,518 0 0
TRACON PHARMACEUTICALS INC COM 89237H100 1,273 339,539 SH   DFND   339,539 0 0
VECTOR GROUP LTD FRNT 1/1 92240MAY4 730 500,000 PRN   DFND   500,000 0 0
VERISIGN INC SDCV 3.250% 8/1 92343EAD4 73,120 28,600,000 PRN   DFND   28,600,000 0 0
WELLS FARGO & CO NEW COM 949746101 7,888 141,712 SH   DFND   141,712 0 0
XENCOR INC COM 98401F105 7,208 301,325 SH   DFND   301,325 0 0