The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
21VIANET GROUP INC SPONSORED ADR 90138A103 28,063 1,535,160 SH   DFND   1,535,160 0 0
ACCELERON PHARMA INC COM 00434H108 21,459 861,813 SH   DFND   861,813 0 0
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107 4,190 350,000 SH   DFND   350,000 0 0
AGENUS INC COM NEW 00847G705 12,329 2,680,321 SH   DFND   2,680,321 0 0
ALTERA CORP COM 021441100 17,962 358,667 SH   DFND   358,667 0 0
ANACOR PHARMACEUTICALS INC COM 032420101 8,136 69,122 SH   DFND   69,122 0 0
ARBUTUS BIOPHARMA CORP COM 03879J100 97,522 16,013,540 SH   DFND 0 0 16,013,540 0
ARRAY BIOPHARMA INC NOTE 3.000% 6/0 04269XAA3 2,977 3,000,000 PRN   DFND   3,000,000 0 0
ARROWHEAD RESH CORP COM NEW 042797209 11,240 1,951,382 SH   DFND   1,951,382 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 5,115 535,000 SH   DFND   535,000 0 0
AXOVANT SCIENCES LTD COM G0750W104 969,000 75,000,000 SH   DFND 0 0 75,000,000 0
BELLICUM PHARMACEUTICALS INC COM 079481107 4,617 317,742 SH   DFND   317,742 0 0
BIOCRYST PHARMACEUTICALS COM 09058V103 15,482 1,358,097 SH   DFND   1,358,097 0 0
BLUEBIRD BIO INC COM 09609G100 10,082 117,844 SH   DFND   117,844 0 0
BONA FILM GROUP LTD SPONSORED ADS 09777B107 7,613 639,211 SH   DFND   639,211 0 0
BRF SA SPONSORED ADR 10552T107 10,801 607,112 SH   DFND   607,112 0 0
CAL MAINE FOODS INC COM NEW 128030202 25,656 469,800 SH   DFND   469,800 0 0
CAPITAL ONE FINL CORP COM 14040H105 19,943 275,000 SH   DFND   275,000 0 0
CBRE GROUP INC CL A 12504L109 19,520 610,000 SH   DFND   610,000 0 0
CHINA ZENIX AUTO INTL LTD ADS 16951E104 4,773 6,074,805 SH   DFND   6,074,805 0 0
CITIZENS FINL GROUP INC COM 174610105 14,912 625,000 SH   DFND   625,000 0 0
CTRIP COM INTL LTD NOTE 1.250%10/1 22943FAD2 38,118 35,000,000 PRN   DFND   35,000,000 0 0
CYTRX CORP COM PAR $.001 232828509 12,950 5,850,399 SH   DFND   5,850,399 0 0
DHT HOLDINGS INC DEBT 4.500%10/0 23335SAB2 19,526 17,000,000 PRN   DFND   17,000,000 0 0
DYAX CORP COM 26746E103 7,111 372,510 SH   DFND   372,510 0 0
E HOUSE CHINA HLDGS LTD ADR 26852W103 4,814 810,400 SH   DFND   810,400 0 0
EBAY INC COM 278642103 30,995 1,268,210 SH   DFND   1,268,210 0 0
ELECTRONIC ARTS INC NOTE 0.750% 7/1 285512AA7 101,589 47,700,000 PRN   DFND   47,700,000 0 0
ELONG INC SPONSORED ADR 290138205 8,401 493,620 SH   DFND   493,620 0 0
EPIZYME INC COM 29428V104 8,408 653,828 SH   DFND   653,828 0 0
EQUITY COMWLTH COM SH BEN INT 294628102 34,461 1,265,079 SH   DFND   1,265,079 0 0
FIBROCELL SCIENCE INC COM NEW 315721209 7,202 1,870,556 SH   DFND   1,870,556 0 0
FIRST SOLAR INC COM 336433107 4,275 100,000 SH Put DFND   100,000 0 0
FIVE PRIME THERAPEUTICS INC COM 33830X104 5,669 368,362 SH   DFND   368,362 0 0
GOLAR LNG LTD BERMUDA SHS G9456A100 7,074 253,725 SH   DFND   253,725 0 0
GOLDMAN SACHS GROUP INC COM 38141G104 13,032 75,000 SH   DFND   75,000 0 0
HALOZYME THERAPEUTICS INC COM 40637H109 6,531 486,276 SH   DFND   486,276 0 0
INTEL CORP COM 458140100 14,070 466,810 SH   DFND   466,810 0 0
INTEL CORP SDCV 12/1 458140AD2 45,840 37,420,000 PRN   DFND   37,420,000 0 0
INTERCEPT PHARMACEUTICALS IN COM 45845P108 705 4,251 SH   DFND   4,251 0 0
ISHARES US HOME CONS ETF 464288752 3,797 145,473 SH   DFND   145,473 0 0
ISHARES TR NASDQ BIOTEC ETF 464287556 24,163 79,660 SH   DFND   79,660 0 0
JPMORGAN CHASE & CO COM 46625H100 5,487 90,000 SH   DFND   90,000 0 0
LION BIOTECHNOLOGIES INC COM 53619R102 8,258 1,433,700 SH   DFND   1,433,700 0 0
LUMBER LIQUIDATORS HLDGS INC COM 55003T107 11,908 906,273 SH   DFND   906,273 0 0
LUMBER LIQUIDATORS HLDGS INC COM 55003T107 44,487 3,385,600 SH Put DFND   3,385,600 0 0
MAKEMYTRIP LIMITED MAURITIUS SHS V5633W109 19,965 1,452,013 SH   DFND   1,452,013 0 0
MARVELL TECHNOLOGY GROUP LTD ORD G5876H105 9,956 1,100,110 SH   DFND   1,100,110 0 0
MEDGENICS INC COM NEW 58436Q203 2,093 267,608 SH   DFND   267,608 0 0
MICROCHIP TECHNOLOGY INC SDCV 2.125%12/1 595017AB0 32,159 18,264,000 PRN   DFND   18,264,000 0 0
MICRON TECHNOLOGY INC NOTE 1.625% 2/1 595112AU7 13,394 9,000,000 PRN   DFND   9,000,000 0 0
MIRATI THERAPEUTICS INC COM 60468T105 9,560 277,733 SH   DFND   277,733 0 0
NAVIGATOR HOLDINGS LTD SHS Y62132108 16,195 1,213,075 SH   DFND   1,213,075 0 0
NEW YORK TIMES CO CL A 650111107 23,925 2,025,798 SH   DFND   2,025,798 0 0
NORTHSTAR RLTY FIN CORP COM NEW 66704R704 5,087 411,900 SH   DFND   411,900 0 0
NOVELLUS SYS INC NOTE 2.625% 5/1 670008AD3 69,784 35,443,000 PRN   DFND   35,443,000 0 0
OCERA THERAPEUTICS INC COM 67552A108 2,319 752,578 SH   DFND   752,578 0 0
ONCOTHYREON INC COM 682324108 1,683 614,370 SH   DFND   614,370 0 0
PACIFIC DATAVISION INC COM 694171307 19,300 676,699 SH   DFND   676,699 0 0
PALATIN TECHNOLOGIES INC COM PAR $ .01 696077403 2,825 4,982,174 SH   DFND   4,982,174 0 0
RADIAN GROUP INC NOTE 2.250% 3/0 750236AN1 15,113 10,000,000 PRN   DFND   10,000,000 0 0
REALOGY HLDGS CORP COM 75605Y106 27,846 740,000 SH   DFND   740,000 0 0
REGENERON PHARMACEUTICALS NOTE 1.875%10/0 75886FAD9 111,303 20,181,000 PRN   DFND   20,181,000 0 0
RETROPHIN INC COM 761299106 6,009 296,570 SH   DFND   296,570 0 0
SELECT SECTOR SPDR TR SBI INT-ENERGY 81369Y506 12,523 204,628 SH   DFND   204,628 0 0
SOLARCITY CORP COM 83416T100 17,375 406,816 SH   DFND   406,816 0 0
SOLARCITY CORP COM 83416T100 17,340 406,000 SH Put DFND   406,000 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 977 5,100 SH Put DFND   5,100 0 0
SPDR SERIES TRUST S&P BIOTECH 78464A870 404,314 6,495,000 SH Put DFND   6,495,000 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADR 874039100 10,375 500,000 SH Put DFND   500,000 0 0
TEEKAY TANKERS LTD CL A Y8565N102 4,604 667,256 SH   DFND   667,256 0 0
TENET HEALTHCARE CORP COM NEW 88033G407 22,189 601,005 SH   DFND   601,005 0 0
TRACON PHARMACEUTICALS INC COM 89237H100 3,549 363,292 SH   DFND   363,292 0 0
UNITED THERAPEUTICS CORP DEL NOTE 1.000% 9/1 91307CAF9 61,774 22,500,000 PRN   DFND   22,500,000 0 0
VERISIGN INC SDCV 3.250% 8/1 92343EAD4 41,856 20,000,000 PRN   DFND   20,000,000 0 0
VIPSHOP HLDGS LTD NOTE 1.500% 3/1 92763WAA1 19,196 17,500,000 PRN   DFND   17,500,000 0 0
VIVINT SOLAR INC COM 92854Q106 8,093 772,214 SH   DFND   772,214 0 0
WAYFAIR INC CL A 94419L101 6,136 175,000 SH   DFND   175,000 0 0
WAYFAIR INC CL A 94419L101 14,024 400,000 SH Put DFND   400,000 0 0
WELLS FARGO & CO NEW COM 949746101 17,972 349,997 SH   DFND   349,997 0 0
WESCO INTL INC DBCV 6.000% 9/1 95082PAH8 64,652 39,000,000 PRN   DFND   39,000,000 0 0
WL ROSS HLDG CORP COM SHS 92939D104 10,380 1,000,000 SH   DFND   1,000,000 0 0
XENCOR INC COM 98401F105 4,732 386,925 SH   DFND   386,925 0 0
YY INC NOTE 2.250% 4/0 98426TAB2 4,686 5,000,000 PRN   DFND   5,000,000 0 0
ZILLOW GROUP INC CL A 98954M101 2,873 100,000 SH   DFND   100,000 0 0