The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACCELERON PHARMA INC COM 00434H108 21,592 556,574 SH   DFND   556,574 0 0
ACHILLION PHARMACEUTICALS IN COM 00448Q201 35,901 10,816,953 SH   DFND   10,816,953 0 0
ALTISOURCE PORTFOLIO SOLNS S REG SHS L0175J104 22,177 139,801 SH   DFND   139,801 0 0
ALTISOURCE PORTFOLIO SOLNS S REG SHS L0175J104 14,324 90,300 SH Put DFND   90,300 0 0
ANACOR PHARMACEUTICALS INC COM 032420101 20,514 1,222,503 SH   DFND   1,222,503 0 0
ARM HLDGS PLC SPONSORED ADR 042068106 12,046 220,100 SH Put DFND   220,100 0 0
ARRAY BIOPHARMA INC COM 04269X105 13,194 2,633,600 SH   DFND   2,633,600 0 0
ARRAY BIOPHARMA INC NOTE 3.000% 6/0 04269XAA3 9,428 9,000,000 PRN   DFND   9,000,000 0 0
ARROWHEAD RESH CORP COM NEW 042797209 21,108 2,047,782 SH   DFND   2,047,782 0 0
BIOCRYST PHARMACEUTICALS COM 09058V103 3,996 525,734 SH   DFND   525,734 0 0
BRF SA SPONSORED ADR 10552T107 20,812 997,220 SH   DFND   997,220 0 0
CAPITAL ONE FINL CORP COM 14040H105 34,255 447,135 SH   DFND   447,135 0 0
CBRE GROUP INC CL A 12504L109 21,864 831,320 SH   DFND   831,320 0 0
CHINA ZENIX AUTO INTL LTD ADS 16951E104 6,451 3,539,766 SH   DFND   3,539,766 0 0
CITIGROUP INC COM NEW 172967424 23,104 443,373 SH   DFND   443,373 0 0
CLOVIS ONCOLOGY INC COM 189464100 24,038 398,835 SH   DFND   398,835 0 0
CMS ENERGY CORP NOTE 5.500% 6/1 125896BD1 4,953 2,500,000 PRN   DFND   2,500,000 0 0
CREE INC COM 225447101 37,512 600,000 SH Put DFND   600,000 0 0
CUBIST PHARMACEUTICALS INC RIGHT 99/99/9999 229678123 773 572,366 SH   DFND   572,366 0 0
CYTRX CORP COM PAR $.001 232828509 13,013 2,075,500 SH   DFND   2,075,500 0 0
DYAX CORP COM 26746E103 19,899 2,640,900 SH   DFND   2,640,900 0 0
E TRADE FINANCIAL CORP NOTE 8/3 269246AZ7 49,786 26,214,000 PRN   DFND   26,214,000 0 0
E TRADE FINANCIAL CORP COM NEW 269246401 14,699 748,418 SH   DFND   748,418 0 0
EPIZYME INC COM 29428V104 2,600 125,000 SH   DFND   125,000 0 0
FEDERATED INVS INC PA CL B 314211103 2,880 100,000 SH Put DFND   100,000 0 0
GREEN DOT CORP CL A 39304D102 7,610 302,600 SH Call DFND   302,600 0 0
GREEN DOT CORP CL A 39304D102 27,500 1,093,442 SH   DFND   1,093,442 0 0
HALOZYME THERAPEUTICS INC COM 40637H109 63,240 4,218,800 SH   DFND   4,218,800 0 0
HOME LN SERVICING SOLUTIONS ORD SHS G6648D109 815 35,500 SH Put DFND   35,500 0 0
HOME LN SERVICING SOLUTIONS ORD SHS G6648D109 1,608 70,000 SH   DFND   70,000 0 0
ILLUMINA INC NOTE 0.625% 2/1 452327AB5 81,737 16,135,000 PRN   DFND   16,135,000 0 0
INFINITY PHARMACEUTICALS INC COM 45665G303 9,956 720,947 SH   DFND   720,947 0 0
INTERMUNE INC COM 45884X103 27,570 1,871,681 SH   DFND   1,871,681 0 0
INTERMUNE INC NOTE 2.500%12/1 45884XAF0 12,431 9,000,000 PRN   DFND   9,000,000 0 0
JPMORGAN CHASE & CO COM 46625H100 23,378 399,760 SH   DFND   399,760 0 0
KERYX BIOPHARMACEUTICALS INC COM 492515101 11,059 854,000 SH   DFND   854,000 0 0
LEGG MASON INC COM 524901105 29,743 684,068 SH   DFND   684,068 0 0
LUMBER LIQUIDATORS HLDGS INC COM 55003T107 28,490 276,900 SH   DFND   276,900 0 0
LUMBER LIQUIDATORS HLDGS INC COM 55003T107 23,449 227,900 SH Put DFND   227,900 0 0
MEDIVATION INC COM 58501N101 15,542 243,528 SH   DFND   243,528 0 0
MIRATI THERAPEUTICS INC COM 60468T105 8,236 540,978 SH   DFND   540,978 0 0
NATIONSTAR MTG HLDGS INC COM 63861C109 3,696 100,000 SH Put DFND   100,000 0 0
NAVIGATOR HOLDINGS LTD SHS Y62132108 22,510 835,543 SH   DFND   835,543 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 593 63,500 SH   DFND   63,500 0 0
NORTHSTAR RLTY FIN CORP COM 66704R100 10,760 800,001 SH   DFND   800,001 0 0
OCERA THERAPEUTICS INC COM 67552A108 8,645 728,827 SH   DFND   728,827 0 0
OCWEN FINL CORP COM NEW 675746309 74,968 1,352,000 SH Put DFND   1,352,000 0 0
OCWEN FINL CORP COM NEW 675746309 29,666 535,000 SH Call DFND   535,000 0 0
OCWEN FINL CORP COM NEW 675746309 45,489 820,354 SH   DFND   820,354 0 0
ONCOTHYREON INC COM 682324108 10,036 5,702,299 SH   DFND   5,702,299 0 0
OREXIGEN THERAPEUTICS INC COM 686164104 1,456 258,672 SH   DFND   258,672 0 0
PALATIN TECHNOLOGIES INC COM PAR $ .01 696077403 2,431 3,873,000 SH   DFND   3,873,000 0 0
PEREGRINE SEMICONDUCTOR CORP COM 71366R703 5,928 800,000 SH   DFND   800,000 0 0
PHARMACYCLICS INC COM 716933106 14,706 139,021 SH   DFND   139,021 0 0
PHH CORP COM NEW 693320202 20,567 844,655 SH   DFND   844,655 0 0
REPROS THERAPEUTICS INC *W EXP 02/08/201 76028H126 10,813 708,969 SH   DFND   708,969 0 0
REPROS THERAPEUTICS INC COM NEW 76028H209 7,808 440,091 SH   DFND   440,091 0 0
REPROS THERAPEUTICS INC *W EXP 02/08/201 76028H118 15,509 874,635 SH   DFND   874,635 0 0
ROWAN COMPANIES PLC SHS CL A G7665A101 34,510 975,954 SH   DFND   975,954 0 0
SALESFORCE COM INC NOTE 0.750% 1/1 79466LAB0 135,826 52,500,000 PRN   DFND   52,500,000 0 0
SBA COMMUNICATIONS CORP NOTE 4.000%10/0 78388JAM8 51,972 17,500,000 PRN   DFND   17,500,000 0 0
SCORPIO TANKERS INC SHS Y7542C106 18,125 1,537,284 SH   DFND   1,537,284 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 21,239 115,000 SH Call DFND   115,000 0 0
STEMLINE THERAPEUTICS INC COM 85858C107 2,156 110,000 SH   DFND   110,000 0 0
SVB FINL GROUP COM 78486Q101 24,799 236,500 SH Put DFND   236,500 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADR 874039100 13,277 761,300 SH Put DFND   761,300 0 0
TENET HEALTHCARE CORP COM NEW 88033G407 66,155 1,570,643 SH   DFND   1,570,643 0 0
THE9 LTD ADR 88337K104 1,468 752,963 SH   DFND   752,963 0 0
TWO HBRS INVT CORP COM 90187B101 4,269 460,000 SH   DFND   460,000 0 0
UNIVERSAL DISPLAY CORP COM 91347P105 10,308 300,000 SH Put DFND   300,000 0 0
VERASTEM INC COM 92337C104 3,091 271,101 SH   DFND   271,101 0 0
VIVUS INC COM 928551100 59,181 6,517,748 SH   DFND   6,517,748 0 0
WALTER ENERGY INC COM 93317Q105 820 49,300 SH   DFND   49,300 0 0
WELLS FARGO & CO NEW COM 949746101 23,194 510,892 SH   DFND   510,892 0 0
WESCO INTL INC DBCV 6.000% 9/1 95082PAH8 61,877 19,000,000 PRN   DFND   19,000,000 0 0
XENCOR INC COM 98401F105 7,312 800,000 SH   DFND   800,000 0 0
YPF SOCIEDAD ANONIMA SPON ADR CL D 984245100 56,247 1,706,509 SH   DFND   1,706,509 0 0
ZIPREALTY INC COM 98974V107 558 99,695 SH   DFND   99,695 0 0