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<SEC-DOCUMENT>0000902664-10-000565.txt : 20100212
<SEC-HEADER>0000902664-10-000565.hdr.sgml : 20100212
<ACCEPTANCE-DATETIME>20100211205217
ACCESSION NUMBER:		0000902664-10-000565
CONFORMED SUBMISSION TYPE:	SC 13G/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20100212
DATE AS OF CHANGE:		20100211

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			NPS PHARMACEUTICALS INC
		CENTRAL INDEX KEY:			0000890465
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				870439579
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-44877
		FILM NUMBER:		10593782

	BUSINESS ADDRESS:	
		STREET 1:		550 HILLS DRIVE
		CITY:			BEDMINSTER
		STATE:			NJ
		ZIP:			07921
		BUSINESS PHONE:		(908) 450-5300

	MAIL ADDRESS:	
		STREET 1:		550 HILLS DRIVE
		CITY:			BEDMINSTER
		STATE:			NJ
		ZIP:			07921

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			GLG Partners LP
		CENTRAL INDEX KEY:			0001289643
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			X0
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		1 CURZON STREET
		CITY:			LONDON
		STATE:			X0
		ZIP:			W1J 5HB
		BUSINESS PHONE:		44 20 7016 7000

	MAIL ADDRESS:	
		STREET 1:		1 CURZON STREET
		CITY:			LONDON
		STATE:			X0
		ZIP:			W1J 5HB
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G/A
<SEQUENCE>1
<FILENAME>p10-0205sc13ga.txt
<DESCRIPTION>NPS PHARMACEUTICALS, INC.
<TEXT>
                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                             ----------------------

                                 SCHEDULE 13G/A

                    Under the Securities Exchange Act of 1934
                               (Amendment No. 2)*

                            NPS Pharmaceuticals, Inc.
                                (Name of Issuer)

                         Common Stock, $0.001 par value
                         (Title of Class of Securities)

                                    62936P103
                                 (CUSIP Number)

                                December 31, 2009
             (Date of Event Which Requires Filing of this Statement)


     Check the appropriate box to designate the rule pursuant to which this
Schedule is filed:
     [ ] Rule 13d-1(b)
     [X] Rule 13d-1(c)
     [ ] Rule 13d-1(d)





- ----------------
     *The remainder of this cover page shall be filled out for a reporting
person's initial filing on this form with respect to the subject class of
securities, and for any subsequent amendment containing information which would
alter the disclosures provided in a prior cover page.

      The information required in the remainder of this cover page shall not be
deemed to be "filed" for purposes of Section 18 of the Securities Exchange Act
of 1934 ("Act") or otherwise subject to the liabilities of that section of the
Act but shall be subject to all other provisions of the Act (however, see the
Notes).






                                Page 1 of 7 Pages


<PAGE>


CUSIP No.  62936P103                 13G/A                  Page 2 of 7 Pages

- ---------------------------------------------------------------------
     (1)    NAMES OF REPORTING PERSONS

            GLG Partners LP
- -----------------------------------------------------------------------
     (2)    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
            (see instructions)
                                                               (a) [X]
                                                               (b) [ ]
- -----------------------------------------------------------------------
     (3)    SEC USE ONLY
- -----------------------------------------------------------------------
     (4)    CITIZENSHIP OR PLACE OF ORGANIZATION

            United Kingdom
- -----------------------------------------------------------------------
NUMBER OF      (5)  SOLE VOTING POWER
                    0
SHARES         -----------------------------------------------------------

BENEFICIALLY   (6)  SHARED VOTING POWER
                    2,689,253 Shares
OWNED BY       -----------------------------------------------------------

EACH           (7)  SOLE DISPOSITIVE POWER
                    0
REPORTING      -----------------------------------------------------------

PERSON WITH:   (8)  SHARED DISPOSITIVE POWER
                    2,689,253 Shares
- -----------------------------------------------------------------------
     (9)    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
            2,689,253 Shares
- -----------------------------------------------------------------------
     (10)   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
            SHARES (see instructions)
                                                                   [ ]
- -----------------------------------------------------------------------
     (11)   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
            5.55%
- -----------------------------------------------------------------------
     (12)   TYPE OF REPORTING PERSON (see instructions)
            PN
- -----------------------------------------------------------------------


<PAGE>


CUSIP No.  62936P103                 13G/A                  Page 3 of 7 Pages


- -----------------------------------------------------------------------
     (1)    NAMES OF REPORTING PERSONS

            GLG Partners Limited
- -----------------------------------------------------------------------
     (2)    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
            (see instructions)
                                                               (a) [X]
                                                               (b) [ ]
- -----------------------------------------------------------------------
     (3)    SEC USE ONLY
- -----------------------------------------------------------------------
     (4)    CITIZENSHIP OR PLACE OF ORGANIZATION

            United Kingdom
- -----------------------------------------------------------------------
NUMBER OF      (5)  SOLE VOTING POWER
                    0
SHARES         ---------------------------------------------------------

BENEFICIALLY   (6)  SHARED VOTING POWER
                    2,689,253 Shares
OWNED BY       ----------------------------------------------------------

EACH           (7)  SOLE DISPOSITIVE POWER
                    0
REPORTING      ----------------------------------------------------------

PERSON WITH:   (8)  SHARED DISPOSITIVE POWER
                    2,689,253 Shares
- -----------------------------------------------------------------------
     (9)    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
            2,689,253 Shares
- -----------------------------------------------------------------------
     (10)   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
            SHARES (see instructions)
                                                                   [ ]
- -----------------------------------------------------------------------
     (11)   PERCENT OF CLASS REPRESENTED
            BY AMOUNT IN ROW (9)
            5.55%
- -----------------------------------------------------------------------
     (12)   TYPE OF REPORTING PERSON (see instructions)
            IA, HC
- -----------------------------------------------------------------------



<PAGE>


CUSIP No.  62936P103                 13G/A                  Page 4 of 7 Pages


- ---------------------------------------------------------------------
     (1)    NAMES OF REPORTING PERSONS

            GLG Partners, Inc.
- -----------------------------------------------------------------------
     (2)    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
            (see instructions)
                                                               (a) [X]
                                                               (b) [ ]
- -----------------------------------------------------------------------
     (3)    SEC USE ONLY
- -----------------------------------------------------------------------
     (4)    CITIZENSHIP OR PLACE OF ORGANIZATION

            Delaware
- -----------------------------------------------------------------------
NUMBER OF      (5)  SOLE VOTING POWER
                    0
SHARES         ----------------------------------------------------------

BENEFICIALLY   (6)  SHARED VOTING POWER
                    2,689,253 Shares
OWNED BY       ----------------------------------------------------------

EACH           (7)  SOLE DISPOSITIVE POWER
                    0
REPORTING      ----------------------------------------------------------

PERSON WITH:   (8)  SHARED DISPOSITIVE POWER
                    2,689,253 Shares
- -----------------------------------------------------------------------
     (9)    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
            2,689,253 Shares
- -----------------------------------------------------------------------
     (10)   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
            SHARES (see instructions)
                                                                   [ ]
- -----------------------------------------------------------------------
     (11)   PERCENT OF CLASS REPRESENTED
            BY AMOUNT IN ROW (9)
            5.55%
- -----------------------------------------------------------------------
     (12)   TYPE OF REPORTING PERSON (see instructions)
            CO
- -----------------------------------------------------------------------



<PAGE>


CUSIP No.  62936P103                 13G/A                  Page 5 of 7 Pages


This Amendment No. 2 (this "Amendment") amends the statement on Schedule 13G
filed on August 5, 2008 (the "Original Schedule 13G"), as amended by Amendment
No. 1, filed on February 9, 2009 (the Original Schedule 13G as amended, the
"Schedule 13G") with respect to shares of Common Stock, par value $0.001 per
share (the "Shares") of NPS Pharmaceuticals, Inc., a Delaware corporation (the
"Company"). Capitalized terms used herein and not otherwise defined in this
Amendment have the meanings set forth in the Original Schedule 13G. This
Amendment amends and restates Items 2(a) and 4 in their entirety as set forth
below.

Item 2(a).  Name of Person Filing

      This statement is filed by the entities and persons listed below, who are
      collectively referred to herein as "Reporting Persons," with respect to
      Shares (as defined in Item 2(d) below) of the Company:

      INVESTMENT MANAGER

      (ii)  GLG Partners, LP (the "Investment Manager"), with respect to the
            Shares held by certain funds and managed accounts to which the
            Investment Manager serves as investment manager (collectively, the
            "GLG Funds").

      GENERAL PARTNER

      (iii) GLG Partners Limited (the "General Partner"), which serves as the
            general partner of the Investment Manager, with respect to the
            Shares held by each of the GLG Funds.

      PARENT COMPANY

      (iv)  GLG Partners, Inc. (the "Parent Company"), which indirectly wholly
            owns the General Partner, with respect to the Shares held by each of
            the GLG Funds.

      The Investment Manager serves as the investment manager to each of the GLG
      Funds. The General Partner serves as the general partner to the Investment
      Manager. The Parent Company indirectly wholly owns the General Partner.


Item 4.   Ownership

      Provide the following information regarding the aggregate number and
percentage of the class of securities of the issuer identified in Item 1.

The information required by Items 4(a) - (c) is set forth in Rows 5 - 11 of the
cover page for each Reporting Person hereto and is incorporated herein by
reference for each such Reporting Person. The Company's quarterly report for the
quarterly period ended September 30, 2009 filed on Form 10-Q on November 5,
2009, indicates that as of October 29, 2009, there were 48,428,851 Shares
outstanding.

The Investment Manager, which serves as the investment manager to each of the
GLG Funds, may be deemed to be the beneficial owner of all Shares owned by the
GLG Funds. The Investment Manager exercises its investment authority directly or
indirectly through various entities, including, without limitation, GLG, Inc.
The General Partner, as general partner to the Investment Manager, may be deemed




<PAGE>


CUSIP No.  62936P103                 13G/A                  Page 6 of 7 Pages


to be the beneficial owner of all Shares owned by the GLG Funds. Each of
Emmanuel Roman, Pierre Lagrange and Noam Gottesman are the Managing Directors of
the General Partner. The Parent Company, which indirectly wholly owns the
General Partner, may be deemed to be the beneficial owner of all Shares owned by
the GLG Funds. Each of the Investment Manager, the General Partner, the Parent
Company, GLG, Inc., Emmanuel Roman, Pierre Lagrange and Noam Gottesman hereby
disclaims any beneficial ownership of any such Shares, except for their
pecuniary interest therein.








<PAGE>



CUSIP No.  62936P103                 13G/A                  Page 7 of 7 Pages


                                   SIGNATURES

      After reasonable inquiry and to the best of its knowledge and belief, each
of the undersigned certifies that the information with respect to it set forth
in this statement is true, complete, and correct.

Dated: February 11, 2010

GLG PARTNERS LP

     By: /s/ Victoria Parry
         ------------------
         Name:  Victoria Parry
         Title: Senior Legal Counsel of GLG Partners LP

GLG PARTNERS LIMITED,
      Individually and in its capacity as General Partner of GLG Partners LP

     By: /s/ Emmanuel Roman
         ------------------
         Name:  Emmanuel Roman
         Title: Managing Director

GLG PARTNERS, INC.

     By: /s/ Alejandro R. San Miguel
         ---------------------------
         Name:  Alejandro R. San Miguel
         Title: General Counsel and Corporate Secretary








</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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