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Shareholders' Equity
 3 Months Ended
Mar. 31, 2019
Equity [Abstract]  
Shareholders' Equity
Shareholders’ Deficit
Common Stock
For the three months ended March 31, 2019, we received proceeds of $0.1 million upon the exercise of stock options which resulted in the issuance of 10,744 shares of common stock. For the three months ended March 31, 2018, we received proceeds of $0.7 million upon the exercise of stock options and warrants which resulted in the issuance of 75,616 shares of common stock.
Warrants
In connection with the April 2018 amendment to the CRG Loan and the May 2018 borrowing under the CRG Loan, we issued warrants to purchase up to 200,000 shares of our common stock with an exercise price of $23.00 per share and total fair value of $1.4 million. The warrants have a five-year term and remain outstanding as of March 31, 2019.
Interim Condensed Consolidated Statements of Shareholders’ Deficit
The changes in interim balances of the components of our shareholders’ deficit are as follows:
 
Three Months Ended
March 31,
 
2019
 
2018
 
(In thousands)
 
 
 
 
Beginning and ending common stock
$
490


$
483





Beginning additional paid-in capital
$
549,479


$
520,071

Exercise of stock options
108


687

Stock-based compensation expense
3,374


2,966

Ending additional paid-in capital
$
552,961


$
523,724





Beginning accumulated deficit
$
(650,125
)

$
(523,368
)
Net loss
(24,345
)

(30,054
)
Ending accumulated deficit
$
(674,470
)

$
(553,422
)