CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE INCOME (LOSS) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Costs and expenses:
Research and development	$ 112,721	$ 118,775	$ 107,612
Selling, general and administrative	50,668	54,842	49,306
Total costs and expenses	163,389	173,617	156,918
Loss from operations	(163,389)	(173,617)	(156,918)
Loss on early extinguishment of debt			(13,374)
Interest expense	(22,702)	(19,669)	(26,751)
Interest and other income	4,062	1,740	654
Loss from continuing operations before income tax benefit	(182,029)	(191,546)	(196,389)
Income tax benefit	0	0	23,256
Net loss from continuing operations	(182,029)	(191,546)	(173,133)
Net income from discontinued operations, net of tax	229,446	385,781	35,072
Net income (loss)	$ 47,417	$ 194,235	$ (138,061)
Basic net (loss) per share continuing operations	$ (2.90)	$ (3.07)	$ (3.02)
Basic net (loss) per share discontinued operations	3.66	6.19	0.61
Basic net income (loss) per share	0.76	3.12	(2.41)
Diluted net income per share continuing operations	(2.90)	(3.07)	(3.02)
Diluted net income per share discontinued operations	3.66	6.19	0.61
Diluted net income (loss) per share	$ 0.76	$ 3.12	$ (2.41)
Weighted-average shares used to compute basic net income (loss) per share (in shares)	62,737,091	62,344,100	57,176,743
Weighted-average shares used to compute diluted net income (loss) per share (in shares)	62,737,091	62,344,100	57,176,743