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Income Taxes - Reconciliation of Federal Statutory Tax Rate (Details)
12 Months Ended
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2018
Income Taxes      
U.S. Federal statutory rate on net loss (21.00%) (21.00%) (21.00%)
State tax, net of federal tax benefit (3.10%) (2.70%) (2.50%)
Change in valuation allowance 25.10% 28.30% 18.90%
Tax credits (8.00%) (5.90%) (4.60%)
Other (1.00%) 1.30% (0.10%)
Effective tax rate (8.00%)   (9.30%)