EXHIBIT 23

Consent of Independent Registered Public Accounting Firm

We consent to the incorporation by reference in the following Registration Statements and the related Prospectuses of Regions Financial Corporation:

Form S-8 No. 333-117272 pertaining to the stock options and other equity interests issuable under various employee benefit plans

Form S-8 No. 333-161603 pertaining to common stock and other equity interests issuable under various employee benefit plans

Form S-8 No. 333-203597 pertaining to common stock and other equity interests issuable under the Regions Financial Corporation 2015 Long Term Incentive Plan

Form S-8 No. 333-216230 pertaining to common stock issuable under the Regions Financial Corporation 401(k) Plan

Form S-3 ASR No. 333-229810 pertaining to the registration of debt and equity securities

Form S-8 No. 333-251818 pertaining to deferred compensation obligations under the Regions Financial Corporation Directors’ Deferred Investment Plan and the Regions Financial Corporation Non-Qualified Excess 401(k) Plan

of our reports dated February 24, 2021, with respect to the consolidated financial statements of Regions Financial Corporation and subsidiaries, and the effectiveness of internal control over financial reporting of Regions Financial Corporation and subsidiaries, included in this Annual Report (Form 10-K) for the year ended December 31, 2020.

Birmingham, Alabama

February 24, 2021