The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABIVAX SA SPONSORED ADS 00370M103   32,682,325 2,472,188 SH   DFND 1,2 0 2,472,188 0
AMICUS THERAPEUTICS INC COM 03152W109   14,835,360 1,495,500 SH   DFND 1,2 0 1,495,500 0
ANAPTYSBIO INC COM 032724106   626,500 25,000 SH   DFND 1,2 0 25,000 0
ARCELLX INC COMMON STOCK 03940C100   27,153,480 492,000 SH   DFND 1,2 0 492,000 0
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100   11,977,001 3,441,667 SH   DFND 1,2 0 3,441,667 0
CONTEXT THERAPEUTICS INC COM 21077P108   14,875,807 7,419,355 SH   DFND 1,2 0 7,419,355 0
CYTOKINETICS INC COM NEW 23282W605   25,692,264 474,202 SH   DFND 1,2 0 474,202 0
DIANTHUS THERAPEUTICS INC COM 252828108   19,615,203 757,929 SH   DFND 1,2 0 757,929 0
DYNAVAX TECHNOLOGIES CORP COM NEW 268158201   26,660,020 2,374,000 SH   DFND 1,2 0 2,374,000 0
ESPERION THERAPEUTICS INC NE COM 29664W105   12,857,339 5,791,594 SH   DFND 1,2 0 5,791,594 0
EVOLUS INC COM 30052C107   26,601,726 2,451,772 SH   DFND 1,2 0 2,451,772 0
HELIX ACQUISITION CORP II CL A ORD SHS G4444H101   5,110,000 500,000 SH   DFND 1,2 0 500,000 0
INSMED INC COM PAR $.01 457669307   16,750,000 250,000 SH   DFND 1,2 0 250,000 0
IONIS PHARMACEUTICALS INC COM 462222100   15,727,800 330,000 SH   DFND 1,2 0 330,000 0
JASPER THERAPEUTICS INC COM NEW 471871202   9,125,741 402,015 SH   DFND 1,2 0 402,015 0
KALVISTA PHARMACEUTICALS INC COM 483497103   15,768,331 1,338,568 SH   DFND 1,2 0 1,338,568 0
KYVERNA THERAPEUTICS INC COM 501976104   3,743,640 499,152 SH   DFND 1,2 0 499,152 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302   50,400 30,000 SH   DFND 1,2 0 30,000 0
MERUS N V COM N5749R100   30,962,951 523,288 SH   DFND 1,2 0 523,288 0
NEUROGENE INC COM 64135M105   36,546,149 1,004,291 SH   DFND 1,2 0 1,004,291 0
OLEMA PHARMACEUTICALS INC COM 68062P106   8,622,242 796,880 SH   DFND 1,2 0 796,880 0
OPTINOSE INC COM 68404V100   14,276,181 13,727,097 SH   DFND 1,2 0 13,727,097 0
OUTLOOK THERAPEUTICS INC COM 69012T305   12,557,144 1,701,510 SH   DFND 1,2 0 1,701,510 0
PLIANT THERAPEUTICS INC COM 729139105   28,346,288 2,636,864 SH   DFND 1,2 0 2,636,864 0
PUMA BIOTECHNOLOGY INC COM 74587V107   4,846,133 1,486,544 SH   DFND 1,2 0 1,486,544 0
SPYRE THERAPEUTICS INC COM NEW 00773J202   3,164,728 134,612 SH   DFND 1,2 0 134,612 0
TERNS PHARMACEUTICALS INC COM 880881107   7,827,455 1,149,406 SH   DFND 1,2 0 1,149,406 0
TSCAN THERAPEUTICS INC COM 89854M101   5,503,861 940,831 SH   DFND 1,2 0 940,831 0
UROGEN PHARMA LTD COM M96088105   48,767,026 2,906,259 SH   DFND 1,2 0 2,906,259 0
VIRIDIAN THERAPEUTICS INC COM 92790C104   6,505,000 500,000 SH   DFND 1,2 0 500,000 0
VISTAGEN THERAPEUTICS INC COM 92840H400   5,322,096 1,529,338 SH   DFND 1,2 0 1,529,338 0
VOYAGER THERAPEUTICS INC COM 92915B106   12,668,079 1,601,527 SH   DFND 1,2 0 1,601,527 0
ZURA BIO LTD CLASS A ORD SHS G9TY5A101   16,247,844 4,642,241 SH   DFND 1,2 0 4,642,241 0