The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABIVAX SA SPONSORED ADS 00370M103   35,585,307 2,488,483 SH   DFND 1,2 0 2,488,483 0
AEROVATE THERAPEUTICS INC COM 008064107   26,248,993 887,690 SH   DFND 1,2 0 887,690 0
ALPINE IMMUNE SCIENCES INC COM 02083G100   44,733,700 1,128,499 SH   DFND 1,2 0 1,128,499 0
AMICUS THERAPEUTICS INC COM 03152W109   17,616,990 1,495,500 SH   DFND 1,2 0 1,495,500 0
ANAPTYSBIO INC COM 032724106   22,001,612 976,981 SH   DFND 1,2 0 976,981 0
APOGEE THERAPEUTICS INC COM 03770N101   26,580,000 400,000 SH   DFND 1,2 0 400,000 0
ARCELLX INC COMMON STOCK 03940C100   20,865,000 300,000 SH   DFND 1,2 0 300,000 0
ARVINAS INC COM 04335A105   2,935,545 71,113 SH   DFND 1,2 0 71,113 0
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100   7,443,335 1,166,667 SH   DFND 1,2 0 1,166,667 0
CYTOKINETICS INC COM NEW 23282W605   14,176,382 202,202 SH   DFND 1,2 0 202,202 0
DIANTHUS THERAPEUTICS INC COM 252828108   18,750,000 625,000 SH   DFND 1,2 0 625,000 0
DYNAVAX TECHNOLOGIES CORP COM NEW 268158201   15,697,657 1,264,920 SH   DFND 1,2 0 1,264,920 0
ESPERION THERAPEUTICS INC NE COM 29664W105   21,440,000 8,000,000 SH   DFND 1,2 0 8,000,000 0
EVOLUS INC COM 30052C107   34,300,000 2,450,000 SH   DFND 1,2 0 2,450,000 0
HELIX ACQUISITION CORP II CL A ORD SHS G4444H101   5,200,000 500,000 SH   DFND 1,2 0 500,000 0
IMMUNOCORE HLDGS PLC ADS 45258D105   7,475,000 115,000 SH   DFND 1,2 0 115,000 0
INSMED INC COM PAR $.01 457669307   21,041,621 775,585 SH   DFND 1,2 0 775,585 0
INTRA-CELLULAR THERAPIES INC COM 46116X101   10,380,000 150,000 SH   DFND 1,2 0 150,000 0
JASPER THERAPEUTICS INC COM NEW 471871202   11,965,668 407,550 SH   DFND 1,2 0 407,550 0
KYVERNA THERAPEUTICS INC COM 501976104   3,726,000 150,000 SH   DFND 1,2 0 150,000 0
MERUS N V COM N5749R100   10,054,659 223,288 SH   DFND 1,2 0 223,288 0
MIND MEDICINE MINDMED INC COM NEW 60255C885   18,800,000 2,000,000 SH   DFND 1,2 0 2,000,000 0
NEUROGENE INC COM 64135M105   51,118,412 1,004,291 SH   DFND 1,2 0 1,004,291 0
OCULAR THERAPEUTIX INC COM 67576A100   15,731,379 1,728,723 SH   DFND 1,2 0 1,728,723 0
OPTINOSE INC COM 68404V100   12,828,024 8,786,318 SH   DFND 1,2 0 8,786,318 0
OUTLOOK THERAPEUTICS INC COM 69012T305   17,671,200 1,480,000 SH   DFND 1,2 0 1,480,000 0
PLIANT THERAPEUTICS INC COM 729139105   27,592,774 1,851,864 SH   DFND 1,2 0 1,851,864 0
PUMA BIOTECHNOLOGY INC COM 74587V107   7,121,228 1,343,628 SH   DFND 1,2 0 1,343,628 0
SPYRE THERAPEUTICS INC COM NEW 00773J202   4,741,250 125,000 SH   DFND 1,2 0 125,000 0
TERNS PHARMACEUTICALS INC COM 880881107   8,593,436 1,309,975 SH   DFND 1,2 0 1,309,975 0
UROGEN PHARMA LTD COM M96088105   39,308,175 2,620,545 SH   DFND 1,2 0 2,620,545 0
VIRIDIAN THERAPEUTICS INC COM 92790C104   23,375,850 1,335,000 SH   DFND 1,2 0 1,335,000 0
VISTAGEN THERAPEUTICS INC COM 92840H400   9,814,121 1,858,735 SH   DFND 1,2 0 1,858,735 0
XENON PHARMACEUTICALS INC COM 98420N105   19,637,171 456,148 SH   DFND 1,2 0 456,148 0
ZURA BIO LTD CLASS A ORD SHS G9TY5A101   7,087,392 2,757,740 SH   DFND 1,2 0 2,757,740 0