The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABIVAX SA SPONSORED ADS 00370M103   16,585,000 1,550,000 SH   DFND 1,2 0 1,550,000 0
AEROVATE THERAPEUTICS INC COM 008064107   23,482,925 1,037,690 SH   DFND 1,2 0 1,037,690 0
ALKERMES PLC SHS G01767105   24,273,721 875,044 SH   DFND 1,2 0 875,044 0
ALPINE IMMUNE SCIENCES INC COM 02083G100   70,587,433 3,703,433 SH   DFND 1,2 0 3,703,433 0
AMICUS THERAPEUTICS INC COM 03152W109   18,170,295 1,280,500 SH   DFND 1,2 0 1,280,500 0
ANAPTYSBIO INC COM 032724106   20,926,933 976,981 SH   DFND 1,2 0 976,981 0
APOGEE THERAPEUTICS INC COM 03770N101   11,176,000 400,000 SH   DFND 1,2 0 400,000 0
ARCELLX INC COMMON STOCK 03940C100   2,678,652 48,264 SH   DFND 1,2 0 48,264 0
ARVINAS INC COM 04335A105   9,634,815 234,082 SH   DFND 1,2 0 234,082 0
AXSOME THERAPEUTICS INC COM 05464T104   395,005 4,963 SH   DFND 1,2 0 4,963 0
CYTOKINETICS INC COM NEW 23282W605   41,745,000 500,000 SH   DFND 1,2 0 500,000 0
EVOLUS INC COM 30052C107   21,060,000 2,000,000 SH   DFND 1,2 0 2,000,000 0
IMMUNOCORE HLDGS PLC ADS 45258D105   20,017,760 293,000 SH   DFND 1,2 0 293,000 0
INSMED INC COM PAR $.01 457669307   7,001,013 225,912 SH   DFND 1,2 0 225,912 0
INTRA-CELLULAR THERAPIES INC COM 46116X101   7,921,673 110,607 SH   DFND 1,2 0 110,607 0
KARUNA THERAPEUTICS INC COM 48576A100   9,574,428 30,250 SH   DFND 1,2 0 30,250 0
MERUS N V COM N5749R100   550,000 20,000 SH   DFND 1,2 0 20,000 0
MURAL ONCOLOGY PUB LTD CO ORD SHS G63365103   68,133 11,509 SH   DFND 1,2 0 11,509 0
NEUROGENE INC COM 64135M105   19,268,158 994,229 SH   DFND 1,2 0 994,229 0
OCULAR THERAPEUTIX INC COM 67576A100   3,122,000 700,000 SH   DFND 1,2 0 700,000 0
OPTINOSE INC COM 68404V100   11,403,521 8,839,939 SH   DFND 1,2 0 8,839,939 0
PLIANT THERAPEUTICS INC COM 729139105   33,017,862 1,823,184 SH   DFND 1,2 0 1,823,184 0
PUMA BIOTECHNOLOGY INC COM 74587V107   4,733,872 1,093,273 SH   DFND 1,2 0 1,093,273 0
RAPT THERAPEUTICS INC COM 75382E109   27,328,862 1,099,753 SH   DFND 1,2 0 1,099,753 0
SAREPTA THERAPEUTICS INC COM 803607100   7,714,400 80,000 SH   DFND 1,2 0 80,000 0
SPYRE THERAPEUTICS INC COM NEW 00773J202   2,690,000 125,000 SH   DFND 1,2 0 125,000 0
TERNS PHARMACEUTICALS INC COM 880881107   8,501,738 1,309,975 SH   DFND 1,2 0 1,309,975 0
TOURMALINE BIO INC COM 89157D105   17,616,129 672,885 SH   DFND 1,2 0 672,885 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108   30,987,360 648,000 SH   DFND 1,2 0 648,000 0
UROGEN PHARMA LTD COM M96088105   39,308,175 2,620,545 SH   DFND 1,2 0 2,620,545 0
VAXCYTE INC COM 92243G108   22,608,000 360,000 SH   DFND 1,2 0 360,000 0
VISTAGEN THERAPEUTICS INC COM 92840H400   9,553,898 1,858,735 SH   DFND 1,2 0 1,858,735 0
XENON PHARMACEUTICALS INC COM 98420N105   27,636,000 600,000 SH   DFND 1,2 0 600,000 0
ZURA BIO LTD CLASS A ORD SHS G9TY5A101   15,387,650 3,295,000 SH   DFND 1,2 0 3,295,000 0