The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ACADIA PHARMACEUTICALS INC | COM | 004225108 | 30,540 | 2,000,000 | SH | DFND | 1,2 | 2,000,000 | 0 | 0 | |
| ACCELERON PHARMA INC | COM | 00434H108 | 36,778 | 758,000 | SH | DFND | 1,2 | 758,000 | 0 | 0 | |
| ACCELERON PHARMA INC | COM | 00434H108 | 26,109 | 538,100 | SH | Put | DFND | 1,2 | 538,100 | 0 | 0 |
| ACCELERON PHARMA INC | COM | 00434H108 | 689 | 14,200 | SH | Put | DFND | 1,2 | 14,200 | 0 | 0 |
| ACCELERON PHARMA INC | COM | 00434H108 | 5,235 | 107,900 | SH | Call | DFND | 1,2 | 107,900 | 0 | 0 |
| ACHILLION PHARMACEUTICALS INC | COM | 00448Q201 | 8,458 | 2,988,716 | SH | DFND | 1,2 | 2,988,716 | 0 | 0 | |
| ACORDA THERAPEUTICS INC | COM | 00484M106 | 545 | 19,000 | SH | Call | DFND | 1,2 | 19,000 | 0 | 0 |
| ACORDA THERAPEUTICS INC | COM | 00484M106 | 3,642 | 126,900 | SH | Call | DFND | 1,2 | 126,900 | 0 | 0 |
| ALEXION PHARMACEUTICALS INC | COM | 015351109 | 13,719 | 110,506 | SH | DFND | 1,2 | 110,506 | 0 | 0 | |
| ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 25,617 | 260,100 | SH | DFND | 1,2 | 260,100 | 0 | 0 | |
| AMARIN CORP PLC | SPONS ADR NEW | 023111206 | 3,266 | 1,056,825 | SH | DFND | 1,2 | 1,056,825 | 0 | 0 | |
| AMARIN CORP PLC | SPONS ADR NEW | 023111206 | 1,842 | 596,200 | SH | Call | DFND | 1,2 | 596,200 | 0 | 0 |
| AMARIN CORP PLC | SPONS ADR NEW | 023111206 | 1,545 | 500,000 | SH | Call | DFND | 1,2 | 500,000 | 0 | 0 |
| AMARIN CORP PLC | SPONS ADR NEW | 023111206 | 1,545 | 500,000 | SH | Call | DFND | 1,2 | 500,000 | 0 | 0 |
| ARENA PHARMACEUTICALS INC | COM NEW | 040047607 | 13,167 | 302,000 | SH | DFND | 1,2 | 302,000 | 0 | 0 | |
| BIOCRYST PHARMACEUTICALS | COM | 09058V103 | 42,851 | 7,478,275 | SH | DFND | 1,2 | 7,478,275 | 0 | 0 | |
| CTI BIOPHARMA CORP | COM NEW | 12648L601 | 7,654 | 1,537,020 | SH | DFND | 1,2 | 1,537,020 | 0 | 0 | |
| CELLDEX THERAPEUTICS INC NEW | COM | 15117B103 | 405 | 804,483 | SH | DFND | 1,2 | 804,483 | 0 | 0 | |
| COMPUGEN LTD | ORD | M25722105 | 2,506 | 759,494 | SH | DFND | 1,2 | 759,494 | 0 | 0 | |
| CORSICANTO II DESIGNATED ACT | NOTE | 220485AB2 | 10,900 | 10,000,000 | SH | DFND | 1,2 | 10,000,000 | 0 | 0 | |
| CYTOKINETICS INC | COM NEW | 23282W605 | 11,989 | 1,444,481 | SH | DFND | 1,2 | 1,444,481 | 0 | 0 | |
| EXELIXIS INC | COM | 30161Q104 | 28,725 | 1,334,793 | SH | DFND | 1,2 | 1,334,793 | 0 | 0 | |
| EXELIXIS INC | COM | 30161Q104 | 10,760 | 500,000 | SH | Call | DFND | 1,2 | 500,000 | 0 | 0 |
| FIVE PRIME THERAPEUTICS INC | COM | 33830X104 | 19,921 | 1,260,000 | SH | DFND | 1,2 | 1,260,000 | 0 | 0 | |
| GLOBAL BLOOD THERAPEUTICS INC | COM | 37890U108 | 34,822 | 770,400 | SH | DFND | 1,2 | 770,400 | 0 | 0 | |
| GLOBAL BLOOD THERAPEUTICS INC | COM | 37890U108 | 9,040 | 200,000 | SH | Put | DFND | 1,2 | 200,000 | 0 | 0 |
| GLOBAL BLOOD THERAPEUTICS INC | COM | 37890U108 | 12,954 | 286,600 | SH | Call | DFND | 1,2 | 286,600 | 0 | 0 |
| GLOBAL BLOOD THERAPEUTICS INC | COM | 37890U108 | 13,560 | 300,000 | SH | Call | DFND | 1,2 | 300,000 | 0 | 0 |
| GLOBAL BLOOD THERAPEUTICS INC | COM | 37890U108 | 705 | 15,600 | SH | Call | DFND | 1,2 | 15,600 | 0 | 0 |
| IOVANCE BIOTHERAPEUTICS INC | COM | 462260100 | 44,618 | 3,485,745 | SH | DFND | 1,2 | 3,485,745 | 0 | 0 | |
| KURA ONCOLOGY INC | COM | 50127T109 | 47,813 | 2,627,110 | SH | DFND | 1,2 | 2,627,110 | 0 | 0 | |
| NOVELION THERAPEUTICS INC | COM NEW | 67001K202 | 9 | 2,500 | SH | DFND | 1,2 | 2,500 | 0 | 0 | |
| PTC THERAPEUTICS INC | COM | 69366J200 | 52,906 | 1,568,500 | SH | DFND | 1,2 | 1,568,500 | 0 | 0 | |
| PROTAGONIST THERAPEUTICS INC | COM | 74366E102 | 9,903 | 1,473,609 | SH | DFND | 1,2 | 1,473,609 | 0 | 0 | |
| RIGEL PHARMACEUTICALS INC | COM NEW | 766559603 | 9,644 | 3,407,840 | SH | DFND | 1,2 | 3,407,840 | 0 | 0 | |
| SAVARA INC | COM | 805111101 | 13,296 | 1,174,541 | SH | DFND | 1,2 | 1,174,541 | 0 | 0 | |
| SIERRA ONCOLOGY INC | COM | 82640U107 | 6,752 | 2,280,921 | SH | DFND | 1,2 | 2,280,921 | 0 | 0 | |
| SPARK THERAPEUTICS INC | COM | 84652J103 | 41,380 | 500,000 | SH | DFND | 1,2 | 500,000 | 0 | 0 | |
| STREAMLINE HEALTH SOLUTIONS | COM | 86323X106 | 183 | 130,137 | SH | DFND | 1,2 | 130,137 | 0 | 0 | |
| UNITED THERAPEUTICS CORP DEL | COM | 91307C102 | 19,195 | 169,639 | SH | DFND | 1,2 | 169,639 | 0 | 0 | |
| VOYAGER THERAPEUTICS INC | COM | 92915B106 | 14,264 | 730,010 | SH | DFND | 1,2 | 730,010 | 0 | 0 | |
| ZAFGEN INC | COM | 98885E103 | 35,805 | 3,500,000 | SH | DFND | 1,2 | 3,500,000 | 0 | 0 | |
| NOVOCURE LTD | ORD SHS | G6674U108 | 22,348 | 713,998 | SH | DFND | 1,2 | 713,998 | 0 | 0 | |
| FOAMIX PHARMACEUTICALS LTD | SHS | M46135105 | 23,956 | 4,781,708 | SH | DFND | 1,2 | 4,781,708 | 0 | 0 | |