The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACADIA PHARMACEUTICALS INC COM 004225108 7,787 270,000 SH   DFND 1,2 270,000 0 0
ADAMAS PHARMACEUTICALS INC COM 00548A106 43,963 2,601,351 SH   DFND 1,2 2,601,351 0 0
ALIMERA SCIENCES INC COM 016259103 2,477 2,293,675 SH   DFND 1,2 2,293,675 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 1,944 51,935 SH   DFND 1,2 51,935 0 0
ARADIGM CORP COM NO PAR VALUE 038505400 1,267 791,870 SH   DFND 1,2 791,870 0 0
AVEXIS INC COM 05366U100 19,721 413,179 SH   DFND 1,2 413,179 0 0
BIOCRYST PHARMACEUTICALS COM 09058V103 4,589 725,000 SH Put DFND 1,2 725,000 0 0
BIOCRYST PHARMACEUTICALS COM 09058V103 3,165 500,000 SH Call DFND 1,2 500,000 0 0
BOVIE MEDICAL CORP COM 10211F100 10,967 3,055,000 SH   DFND 1,2 3,055,000 0 0
CATABASIS PHARMACEUTICALS INC COM 14875P107 2,009 556,537 SH   DFND 1,2 556,537 0 0
COLUCID PHARMACEUTICALS INC COM 19716T101 15,938 437,865 SH   DFND 1,2 437,865 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 12,998 370,000 SH   DFND 1,2 370,000 0 0
DERMIRA INC COM 24983L104 3,460 114,080 SH   DFND 1,2 114,080 0 0
ENANTA PHARMACEUTICALS INC COM 29251M106 27,746 828,253 SH   DFND 1,2 828,253 0 0
GLOBAL BLOOD THERAPEUTICS INC COM 37890U108 14,450 1,000,000 SH   DFND 1,2 1,000,000 0 0
IGNYTA INC COM 451731103 21,200 4,000,000 SH   DFND 1,2 4,000,000 0 0
INOTEK PHARMACEUTICALS CORP COM 45780V102 9,150 1,500,000 SH   DFND 1,2 1,500,000 0 0
MEDICINES CO COM 584688105 25,455 750,000 SH Put DFND 1,2 750,000 0 0
MERRIMACK PHARMACEUTICALS INC COM 590328100 20,400 5,000,000 SH   DFND 1,2 5,000,000 0 0
MIRATI THERAPEUTICS INC COM 60468T105 4,134 870,261 SH   DFND 1,2 870,261 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 29,025 750,000 SH   DFND 1,2 750,000 0 0
OCERA THERAPEUTICS INC COM 67552A108 4,124 1,963,777 SH   DFND 1,2 1,963,777 0 0
OPHTHOTECH CORP COM 683745103 34 7,100 SH Call DFND 1,2 7,100 0 0
SAGE THERAPEUTICS INC COM 78667J108 19,693 385,683 SH   DFND 1,2 385,683 0 0
STREAMLINE HEALTH SOLUTIONS COM 86323X106 190 151,611 SH   DFND 1,2 151,611 0 0
SUNESIS PHARMACEUTICALS INC COM PAR 867328700 5,567 1,537,873 SH   DFND 1,2 1,537,873 0 0
SYNERGY PHARMACEUTICALS DEL COM NEW 871639308 30,289 4,973,509 SH   DFND 1,2 4,973,509 0 0
TENAX THERAPEUTICS INC COM 88032L100 2,162 1,108,593 SH   DFND 1,2 1,108,593 0 0
THERAPEUTICSMD INC COM 88338N107 18,903 3,276,010 SH   DFND 1,2 3,276,010 0 0
TREVENA INC COM 89532E109 17,644 3,000,650 SH   DFND 1,2 3,000,650 0 0
VANDA PHARMACEUTICALS INC COM 921659108 32,060 2,010,000 SH   DFND 1,2 2,010,000 0 0
ZOGENIX INC COM NEW 98978L204 29,658 2,440,959 SH   DFND 1,2 2,440,959 0 0
MYOVANT SCIENCES LTD COM G637AM102 4,354 350,000 SH   DFND 1,2 350,000 0 0
FOAMIX PHARMACEUTICALS LTD SHS M46135105 33,300 3,000,000 SH   DFND 1,2 3,000,000 0 0
CONNECTURE INC COM 20786J106 6,934 4,127,232 SH   DFND 1,2 4,127,232 0 0