Delaware (State or other jurisdiction of incorporation) | 001-36065 (Commission File Number) | 27-0072226 (I.R.S. Employer Identification Number) | ||
128 Sidney Street Cambridge, MA (Address of principal executive offices) | 02139 (Zip Code) |
ACCELERON PHARMA INC. | ||
By: | /s/ John Quisel, J.D., Ph.D. | |
John Quisel, J.D., Ph.D. | ||
Senior Vice President and General Counsel | ||
Date: August 4, 2016 |
• | Updated results from ongoing luspatercept Phase 2 clinical trial in myelodysplastic syndromes (MDS) presented at the 21st Congress of the European Hematology Association (EHA) confirm activity and durability of response. Results highlighted in an oral presentation showed that 51% (25/49) of patients with lower-risk MDS treated with luspatercept achieved increased hemoglobin levels, and 35% (14/40) of patients achieved transfusion independence in the 3-month base study. In the ongoing extension study, 81% (26/32) of patients had increased hemoglobin levels and 50% (11/22) achieved transfusion independence with luspatercept treatment. Data was presented showing hemoglobin increases being sustained for 15 months. |
• | Updated results from ongoing luspatercept Phase 2 clinical trial in beta-thalassemia also presented at EHA. Results presented showed that 67% (20/30) of patients achieved at least a 33% reduction in transfusion burden, and 36% (8/22) of patients achieved a hemoglobin increase of at least 1.5 g/dL in the luspatercept 3-month base study. In the ongoing long-term extension study, 83% (20/24) of patients achieved at least a 33% reduction in transfusion burden and 56% (15/27) of patients achieved a hemoglobin increase of at least 1.5 g/dL. Data was presented showing hemoglobin increases being sustained for 12 months. |
• | Enrollment is ongoing to explore luspatercept activity in low- or intermediate-risk MDS patients who are erythropoiesis-stimulating agent (ESA) naïve or ring sideroblast negative (RS-). Patients who are eligible to be treated with an ESA but have not yet received such treatment or who are RS-, are being enrolled in a Phase 2 clinical trial. Acceleron plans to present the initial data from these patients by the end of the year. |
• | Results from Phase 1 study of ACE-083 in healthy volunteers were presented at the International Congress on Neuromuscular Diseases. Results demonstrated that ACE-083 produced statistically significant, dose-dependent increases in muscle volume, assessed by magnetic resonance imaging |
• | Progress continues toward the initiation of a Phase 2 trial with ACE-083 in facioscapulohumeral muscular dystrophy (FSHD), a neuromuscular disorder, in the second half of 2016. |
• | Acceleron and Celgene expect to provide a development plan update for sotatercept in the second half of 2016. The companies met with health authorities in the first half of the year as part of assessing the potential future investigation of sotatercept in patients with pre-dialysis chronic kidney disease (CKD) due to diabetic nephropathy. |
• | Enrollment continues in Part 2 of the Phase 2 DART study, a randomized, double-blind study of dalantercept plus axitinib, compared to placebo plus axitinib in patients with advanced renal cell carcinoma (RCC). The primary endpoint of this trial, progression-free survival (PFS), is an event-driven assessment with data potentially available by the end of the year. |
• | Acceleron continues its research on several molecules targeting musculoskeletal diseases, fibrotic disorders and other serious diseases. The most advanced molecule from the IntelliTrap™ platform, ACE-2494, continues to advance through IND-enabling activities. The Company plans to initiate a Phase 1 clinical trial with ACE-2494 in the first half of 2017. |
• | Thomas McCourt appointed to Acceleron’s board of directors. Mr. McCourt brings 30 years of experience building commercial strategies and capabilities across multiple companies for new therapies. He serves as chief commercial officer and senior vice president of marketing and sales of Ironwood Pharmaceuticals. Prior to joining Ironwood in 2009, Mr. McCourt held commercial roles at Amgen, Novartis AG and Astra Merck Inc. |
• | Cash position – Cash, cash equivalents and investments as of June 30, 2016 were $262.7 million. As of December 31, 2015 the Company had cash, cash equivalents and investments of $136.0 million. The Company believes that existing cash, cash equivalents and investments will be sufficient to fund its projected operating requirements into the second half of 2019. |
• | Revenue – Collaboration revenue for the second quarter was $3.2 million. License and milestone revenue was $0.1 million. Cost sharing reimbursement revenue from the Company's Celgene partnership was $3.1 million and is related to expenses incurred by the Company in support of its partnered programs. |
• | Costs and expenses – Total costs and expenses for the second quarter were $22.8 million. This includes R&D expenses of $16.1 million and G&A expenses of $6.7 million. |
• | Other expense, net – Other expense for the second quarter was $2.4 million and includes a $2.9 million, non-cash, loss on marking the Company's common stock warrant liability to market. |
• | Net loss – The Company posted a net loss for the second quarter ended June 30, 2016 of $22.0 million. |
June 30, 2016 | December 31, 2015 | ||||||
Cash, cash equivalents and investments | $ | 36,995 | $ | 27,783 | |||
Short and long-term investments | 225,721 | 108,198 | |||||
Other assets | 11,514 | 10,356 | |||||
Total assets | $ | 274,230 | $ | 146,337 | |||
Deferred revenue | 4,514 | 4,794 | |||||
Warrants to purchase common stock | 11,368 | 17,187 | |||||
Other liabilities | 14,492 | 15,093 | |||||
Total liabilities | 30,374 | 37,074 | |||||
Total stockholders’ equity | 243,856 | 109,263 | |||||
Total liabilities and stockholders’ equity | $ | 274,230 | $ | 146,337 |
Three Months Ended June 30, | Six Months Ended June 30, | ||||||||||||||
2016 | 2015 | 2016 | 2015 | ||||||||||||
Revenue: | |||||||||||||||
Collaboration revenue: | |||||||||||||||
Collaboration revenue | 3,195 | 5,717 | 21,396 | 10,139 | |||||||||||
Costs and expenses: | |||||||||||||||
Research and development | 16,138 | 14,150 | 32,390 | 28,930 | |||||||||||
General and administrative | 6,712 | 4,661 | 12,618 | 9,360 | |||||||||||
Total costs and expenses | 22,850 | 18,811 | 45,008 | 38,290 | |||||||||||
Loss from operations | (19,655 | ) | (13,094 | ) | (23,612 | ) | (28,151 | ) | |||||||
Total other (expense) income, net | (2,361 | ) | 2,711 | 6,656 | 3,196 | ||||||||||
Net loss applicable to common stockholders—basic and diluted | $ | (22,016 | ) | $ | (10,383 | ) | $ | (16,956 | ) | $ | (24,955 | ) | |||
Net loss per share applicable to common stockholders - basic and diluted | $ | (0.59 | ) | $ | (0.32 | ) | $ | (0.46 | ) | $ | (0.76 | ) | |||
Weighted-average number of common shares used in computing net loss per share applicable to common stockholders - basic and diluted | 37,272 | 32,870 | 37,092 | 32,754 |
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