Filed
pursuant to Rule 424(b)(3)
File
Nos. 333-133043
333-129744
Prospectus
Supplement No. 1
(To
Prospectus dated November 21, 2006)
NOVELOS
THERAPEUTICS, INC.
34,285,449
shares of common stock
This
prospectus supplement supplements the Prospectus dated November 21, 2006,
relating to the resale of 34,285,449 shares of our common stock. This prospectus
supplement should be read in conjunction with the Prospectus.
Stock
Option Grants
On
December 11, 2006, we granted options to purchase common stock to the persons
and in the amounts that follow:
Executive
Officers
|
|
Shares
|
Harry
Palmin
|
|
150,000
|
Christopher
J. Pazoles, Ph.D.
|
|
100,000
|
M.
Taylor Burtis
|
|
100,000
|
George
Vaughn
|
|
30,000
|
We
also
granted additional options to purchase up to 230,000 shares of common stock
to
certain other employees and consultants. All of the above options have an
exercise price of $0.91 per share which represents the closing price of our
common stock on December 11, 2006 as reported on the Over the Counter Bulletin
Board and an expiration date of December 11, 2016. The
options were granted as compensation for employment or consulting services,
as
applicable. The options will vest and become exercisable for 1/3 of the maximum
number of shares granted on the first anniversary of the date of grant, and
shall vest and become exercisable for an additional 1/3 on the last day of
each
year thereafter, so that the options shall be fully vested on the third
anniversary of the date of grant. The options granted to employees are evidenced
by an incentive stock option agreement. The options granted to consultants
are
evidenced by a non-statutory stock option agreement.
These
issuances were exempt from registration under the Securities Act of 1933
pursuant to an exemption under Section 4(2) thereof as a sale of securities
not
involving any public offering.
Investing
in our common stock involves a high degree of risk.
See
Risk Factors beginning on page 4 of the Prospectus.
Neither
the Securities and Exchange Commission nor any state securities commission
has
approved or disapproved of these securities or passed on the adequacy or
accuracy of this prospectus supplement. Any representation to the contrary
is a
criminal offense.
The
date
of this prospectus supplement is December 15, 2006