Exhibit 99.1

Exhibit 99.1

MARKETAXESS REPORTS THIRD QUARTER 2010 RECORD REVENUES OF $37.4 MILLION, RECORD PRE-TAX
INCOME OF $13.5 MILLION AND DILUTED EPS OF $0.22

Third Quarter Financial Highlights^*

•		Record revenues of $37.4 million, up 24.7%

•		Record pre-tax income of $13.5 million, up 58.3%

•		Record pre-tax margin of 36.1%, up from 28.5%

•		EBITDA of $15.1 million, up 47.8%

•		Net income of $8.6 million, up 85.6%

•		EPS of $0.22, up 83%

* All comparisons versus third quarter 2009.

NEW YORK, October 27, 2010 — MarketAxess Holdings Inc. (Nasdaq: MKTX), the operator of a leading electronic trading platform for U.S. and European high-grade corporate bonds, emerging markets bonds and other types of fixed-income securities, today announced results for the third quarter ended September 30, 2010.

“Our record revenue and earnings results reflect strong momentum in our core e-trading product areas and disciplined expense management,” said Richard M. McVey, chairman and chief executive officer of MarketAxess. “Operating margins continue to grow and we are investing actively in the new OTC derivative opportunities that are emerging as part of financial market regulatory reform.”

Third Quarter Results

Total revenues for the third quarter of 2010 increased 24.7% to $37.4 million, compared to $30.0 million for the third quarter of 2009. Pre-tax income was a record $13.5 million, compared to $8.5 million for the third quarter of 2009, an increase of 58.3%. Pre-tax margin was 36.1%, compared to 28.5% for the third quarter of 2009. Earnings before interest, taxes, depreciation and amortization (“EBITDA”) for the third quarter of 2010 was $15.1 million, compared to $10.2 million for the third quarter of 2009, an increase of 47.9%. Net income totaled $8.6 million, or $0.22 per share on a diluted basis, compared to $4.6 million, or $0.12 per share on a diluted basis, for the third quarter of 2009.

Commission revenue for the third quarter of 2010 totaled $31.2 million on total trading volume of $100.5 billion, compared to $25.3 million in commission revenue on total trading volume of $80.4 billion for the third quarter of 2009. U.S. high-grade trading volume as a percentage of FINRA’s high-grade TRACE trading volume increased to an estimated 8.3%, compared to an estimated 6.5% for the third quarter of 2009.

Technology products and services revenue, which includes revenue for technology licenses, support and professional services, totaled $3.5 million for the third quarter of 2010, compared to $2.6 million for the third quarter of 2009. Other revenue, which consists of information and user access fees, investment income and other revenue, increased 32.4% to $2.8 million, compared to $2.1 million for the third quarter of 2009.

Total expenses for the third quarter of 2010 increased 11.3% to $23.9 million, compared to $21.5 million for the third quarter of 2009. The majority of the increase was due to higher employee compensation and benefits expense of $1.2 million.

The effective tax rate for the third quarter of 2010 was 36.3%, compared to 45.7% for the third quarter of 2009. The 2010 effective tax rate reflects a refinement in the state and local tax apportionment methodology, which resulted in a lower projected state income tax rate. Also, the 2009 tax expense was negatively impacted by certain newly enacted apportionment rules in New York City.

Employee headcount as of September 30, 2010 was 223, compared to 210 as of September 30, 2009.

Dividend

The Company’s board of directors declared a quarterly cash dividend of $0.07 per share of common stock outstanding or issuable upon conversion of outstanding shares of non-voting common stock and Series B preferred stock, to be paid on November 23, 2010, to stockholders of record as of the close of business on November 9, 2010.

Share Repurchase Program Update

In June 2010, the Company’s board of directors approved a $30 million share repurchase program, which authorizes the Company to repurchase shares of its common stock in the open market or in privately negotiated transactions, at times and prices considered appropriate by the Company. Through September 30, 2010, a total of 1.6 million shares had been repurchased at a cost of $23.3 million.

Balance Sheet Data

As of September 30, 2010, total assets were $287.2 million and total stockholders’ equity, including the Series B preferred stock, was $256.1 million. Cash, cash equivalents and securities was $183.0 million, or $4.72 per diluted share, as of September 30, 2010, compared to $187.6 million as of June 30, 2010. During the third quarter of 2010, the Company expended a total of $25.9 million in cash relating to the share repurchase program and quarterly dividend.

Non-GAAP Financial Measure

EBITDA is a non-GAAP financial measure. The Company believes that this non-GAAP financial measure, when taken into consideration with the corresponding GAAP financial measure, is important in gaining an understanding of the Company’s operating results.

Webcast and Conference Call Information

Richard M. McVey, MarketAxess’ chairman and chief executive officer, T. Kelley Millet, president, and Antonio L. DeLise, chief financial officer, will host a conference call to discuss the Company’s financial results and outlook this morning at 8:30 a.m. Eastern time. To access the conference call, please dial 800-659-1966 (U.S.) or 617-614-2711 (international). The passcode for all callers is 95411626. The Company will also host a live audio Webcast of the conference call on the Investor Relations section of the Company’s website at http://www.marketaxess.com. A replay of the call will be made available by dialing 888-286-8010 (U.S.) or 617-801-6888 (international) for one week after the announcement. The passcode for replay callers is 73997222. The Webcast will also be archived on http://www.marketaxess.com for 90 days following the announcement.

About MarketAxess

MarketAxess operates a leading electronic trading platform that enables investment industry professionals to efficiently trade corporate bonds and other types of fixed-income instruments. MarketAxess’ patented trading technology allows institutional investor clients to request competitive, executable bids or offers from multiple broker-dealers simultaneously, and to execute trades with the broker-dealer of their choice. Over 800 institutional investors are active users of the MarketAxess trading platform, accessing the global liquidity provided by MarketAxess’ 77 broker-dealer clients in U.S. high-grade corporate bonds, European bonds, high yield and emerging markets bonds, agency bonds and credit default swaps. MarketAxess also offers a number of trading-related products and services, including: market data to assist clients with trading decisions; connectivity solutions that facilitate straight-through processing; technology services to optimize trading environments; and execution services for exchange-traded fund managers and other clients.

MarketAxess maintains its headquarters in New York and has offices in London, Chicago and Salt Lake City. For more information, please visit www.marketaxess.com.

Cautionary Note Regarding Forward-Looking Statements

This press release may contain forward-looking statements, including statements about the outlook and prospects for Company and industry growth, as well as statements about the Company’s future financial and operating performance. These and other statements that relate to future results and events are based on MarketAxess’ current expectations. Actual results in future periods may differ materially from the those currently expected or desired because of a number of risks and uncertainties, including: the level and intensity of competition in the fixed-income electronic trading industry and the pricing pressures that may result; the variability of our growth rate; the rapidly evolving nature of the electronic financial services industry; the level of trading volume transacted on the MarketAxess platform; the absolute level and direction of interest rates and the corresponding volatility in the corporate fixed-income market; our ability to develop new products and offerings and the market’s acceptance of those products; our exposure to risks resulting from non-performance by counterparties to transactions executed between our clients in which we act as an intermediary in matching back-to-back trades; our dependence on our broker-dealer clients; our ability to enter into strategic alliances and to acquire other businesses and successfully integrate them with our business; our future capital needs and our ability to obtain capital when needed; and other factors. The Company’s actual results and financial condition may differ, perhaps materially, from the anticipated results and financial condition in any such forward-looking statements. The Company undertakes no obligation to update any forward-looking statements, whether as a result of new information, future events or otherwise. More information about these and other factors affecting MarketAxess’ business and prospects is contained in MarketAxess’ periodic filings with the Securities and Exchange Commission and can be accessed at www.marketaxess.com.

# # #


Media and Investor Relations Contacts:
Tony DeLise		William McBride
MarketAxess Holdings Inc.		Gavin Anderson & Co.
+1-212-813-6017		+1-212-515-1970

MarketAxess Holdings Inc.
Consolidated Statements of Operations


	Three Months Ended				Nine Months Ended
	September 30,				September 30,
	2010		2009		2010		2009
	($ in thousands, except per share data)
	(unaudited)
Revenues
Commissions
U.S. high-grade	$	21,537	$	16,306	$	61,562	$	43,629
Eurobond		4,075		5,497		14,236		14,351
Other		5,540		3,486		14,121		9,585

Total commissions		31,152		25,289		89,919		67,565
Technology products and services		3,455		2,601		9,870		6,720
Information and user access fees		1,603		1,519		4,959		4,678
Investment income		301		314		907		880
Other		902		286		1,968		637

Total revenues		37,413		30,009		107,623		80,480


Expenses
Employee compensation and benefits		14,326		13,127		42,448		36,486
Depreciation and amortization		1,560		1,654		4,798		5,124
Technology and communications		2,543		2,029		7,313		6,391
Professional and consulting fees		2,241		1,645		6,369		5,137
Occupancy		706		706		2,351		2,075
Marketing and advertising		679		651		2,066		2,004
General and administrative		1,834		1,654		5,813		4,253

Total expenses		23,889		21,466		71,158		61,470


Income before taxes		13,524		8,543		36,465		19,010
Provision for income taxes		4,913		3,903		13,984		8,344

Net income	$	8,611	$	4,640	$	22,481	$	10,666


Per Share Data:
Earnings per share:
Basic	$	0.24	$	0.13	$	0.61	$	0.29
Diluted	$	0.22	$	0.12	$	0.57	$	0.28

Cash dividends declared per common share	$	0.07	$	—	$	0.21	$	—

Weighted-average common shares:
Basic		32,945		33,287		33,434		33,242
Diluted		38,744		38,197		39,188		37,856

MarketAxess Holdings Inc.
Consolidated Condensed Balance Sheet Data


	September 30, 2010		December 31, 2009
	($ in thousands)
	(unaudited)
Assets
Cash and cash equivalents	$	108,745	$	103,341
Securities available-for-sale		74,218		70,997
Deferred tax assets, net		20,338		23,980
All other assets		83,868		78,968

Total assets	$	287,169	$	277,286


Liabilities and Stockholders’ Equity
Total liabilities	$	31,103	$	30,469
Series B Preferred Stock		30,315		30,315
Total stockholders’ equity		225,751		216,502

Total liabilities and stockholders’ equity	$	287,169	$	277,286

MarketAxess Holdings Inc.
Reconciliation of Non-GAAP Financial Measures


	Three Months Ended				Nine Months Ended
	September 30,				September 30,
	2010		2009		2010		2009
	($ in thousands, except per share data)
	(unaudited)

Net income	$	8,611	$	4,640	$	22,481	$	10,666

Add back:
Interest expense		19		24		60		62

Provision for income taxes		4,913		3,903		13,984		8,344

Depreciation and amortization		1,560		1,654		4,798		5,124


Earnings before interest, taxes, depreciation and amortization (EBITDA)	$	15,103	$	10,221	$	41,323	$	24,196

MarketAxess Holdings Inc.
Volume Statistics


	Total Trading Volume
	Three Months Ended				Nine Months Ended
	September 30,				September 30,
	2010		2009		2010		2009
	($ in millions)
	(unaudited)

U.S. high-grade — multi dealer¹
fixed-rate	$	59,222	$	45,432	$	173,716	$	117,766
floating-rate		1,165		1,587		6,352		4,002
Eurobond		10,712		16,580		39,470		38,841
Other¹		29,351		16,795		78,395		46,677

Total	$	100,450	$	80,394	$	297,933	$	207,286


	Average Daily Volume
	Three Months Ended				Nine Months Ended
	September 30,				September 30,
	2010		2009		2010		2009
	($ in millions)
	(unaudited)

U.S. high-grade¹	$	944	$	735	$	958	$	648
Eurobond		165		255		209		206
Other¹		459		262		417		248

Total	$	1,568	$	1,252	$	1,584	$	1,102


Number of U.S. Trading Days²		64		64		188		188
Number of U.K. Trading Days³		65		65		189		189


1		Consistent with FINRA TRACE reporting standards, both sides of trades are included in the Company’s reported volumes when the Company executes trades on a riskless principal basis between two counterparties.

2		The number of U.S. trading days is based on the SIFMA holiday recommendation calendar.

3		The number of U.K. trading days is based on the U.K. Bank holiday schedule.