Exhibit 24.1

POWER OF ATTORNEY

Know all by these presents, that the undersigned hereby constitutes and appoints Kerensa Kenny with full power of substitution, the undersigned’s true and lawful attorney-in-fact to:

(1)prepare, execute in the undersigned’s name and on the undersigned’s behalf, and submit to the U.S. Securities and Exchange Commission (the “SEC”) a Form ID, including amendments thereto, and any other documents necessary or appropriate to obtain codes and passwords enabling the undersigned to make electronic filings with the SEC of reports required by Section 16(a) of the Securities Exchange Act of 1934 or any rule or regulation of the SEC;

(2)execute for and on behalf of the undersigned, in the undersigned’s capacity as an officer, director and/or more than 10% stockholder of any Skyline Affiliated Public Portfolio Company (the “Company”), Forms 3, 4, and 5 as well as 13(g) and 13(d) filings, in accordance with Section 16 of the Securities Exchange Act of 1934 and the rules thereunder;

(3)do and perform any and all acts for and on behalf of the undersigned which may be necessary or desirable to complete and execute any such Form 3, 4, or 5, and 13(g) and 13(d), complete and execute any amendment or amendments thereto, and timely file such form with the SEC and any stock exchange or similar authority; and

(4)take any other action of any type whatsoever in connection with the foregoing which, in the opinion of such attorney-in-fact, may be of benefit to, in the best interest of, or legally required by, the undersigned, it being understood that the documents executed by such attorney-in-fact on behalf of the undersigned pursuant to this Power of Attorney shall be in such form and shall contain such terms and conditions as such attorney-in-fact may approve in such attorney-in-fact’s discretion.

The undersigned hereby grants to each such attorney-in-fact full power and authority to do and perform any and every act and thing whatsoever requisite, necessary, or proper to be done in the exercise of any of the rights and powers herein granted, as fully to all intents and purposes as the undersigned might or could do if personally present, with full power of substitution or revocation, hereby ratifying and confirming all that such attorney-in-fact, or such attorney-in-fact’s substitute or substitutes, shall lawfully do or cause to be done by virtue of this power of attorney and the rights and powers herein granted.  The undersigned acknowledges that the foregoing attorney-in-fact, in serving in such capacity at the request of the undersigned, are not assuming, nor is the Company assuming, any of the undersigned’s responsibilities to comply with Section 16 of the Securities Exchange Act of 1934.

This Power of Attorney shall remain in full force and effect until the undersigned is no longer required to file Forms 3, 4, and 5 with respect to the undersigned’s holdings of and transactions in securities issued by the Company, unless earlier revoked by the undersigned in a signed writing delivered to the foregoing attorney-in-fact.  This Power of Attorney supersedes any prior power of attorney granted by the undersigned with respect to Forms 3, 4, and 5, and 13(g) and 13(d).

IN WITNESS WHEREOF, the undersigned has caused this Power of Attorney to be executed as of this 9th day of February, 2011.

Skyline Venture Partners III, L.P.

By Skyline Venture Management III, L.L.C.,

Its General Partner

By:		/s/ John G. Freund
John G. Freund, Managing Director
Skyline Venture Partners Qualified Purchaser Fund III, L.P.
By Skyline Venture Management III, L.L.C.,
Its General Partner
By:	/s/ John G. Freund
John G. Freund, Managing Director
Skyline Venture Partners Qualified Purchaser Fund IV, L.P.
By Skyline Venture Management IV, L.L.C.,
Its General Partner
By:	/s/ John G. Freund
John G. Freund, Managing Director
Skyline Venture Partners V, L.P.
By Skyline Venture Management III, L.L.C.,
Its General Partner
By:	/s/ John G. Freund
John G. Freund, Managing Director
Skyline Expansion Fund, L.P.
By Skyline Expansion Fund Management, L.L.C.,
Its General Partner
By Skyline Venture Management III, L.L.C.
Its Managing Member
By:		/s/ John G. Freund
John G. Freund, Managing Director
John G. Freund
/s/ John G. Freund
Yasunori Kaneko
/s/ Yasunori Kaneko

Stephen J. Hoffman

/s/ Stephen J. Hoffman