EXHIBIT 32.1

REYNOLDS AMERICAN INC.

Certification Pursuant to 18 U.S.C. §1350

            Pursuant to 18 U.S.C. §1350, as adopted pursuant to Section 906 of the Sarbanes—Oxley Act of 2002, the undersigned, Susan M. Ivey, Chief Executive Officer, and Dianne M. Neal, Chief Financial Officer, of Reynolds American Inc. (“RAI”), hereby certifies, to her knowledge, that:

1)	RAI’s Quarterly Report on Form 10-Q for the three months ended March 31, 2007, fully complies with the requirements of section 13(a) or 15(d) of the Securities Exchange Act of 1934; and
2)	the information contained in RAI’s Quarterly Report on Form 10-Q for the three months ended March 31, 2007, fairly presents, in all material respects, the financial condition and results of operations of RAI.
	EXECUTED this 4th day of May, 2007.

/s/ Susan M. Ivey 

Susan M. Ivey, Chairman of the Board, President    and Chief Executive Officer of Reynolds
   American Inc.

/s/ Dianne M. Neal 

Dianne M. Neal, Executive Vice President and
   Chief Financial Officer of Reynolds American
   Inc.