EXHIBIT 32.1

REYNOLDS AMERICAN INC.

Certification Pursuant to 18 U.S.C. §1350

Pursuant to 18 U.S.C. § 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, each of the undersigned, Susan M. Ivey, Chief Executive Officer, and Thomas R. Adams, Chief Financial Officer, of Reynolds American Inc. (“RAI”), hereby certifies, to her or his knowledge, that:

1) RAI’s Quarterly Report on Form 10-Q for the quarter ended March 31, 2010, fully complies with the requirements of section 13(a) or 15(d) of the Securities Exchange Act of 1934; and

2) the information contained in RAI’s Quarterly Report on Form 10-Q for the quarter ended March 31, 2010, fairly presents, in all material respects, the financial condition and results of operations of RAI.

     EXECUTED this 29th day of April, 2010.

/s/ Susan M. Ivey  

Susan M. Ivey, Chairman of the Board, President and 

Chief Executive Officer of Reynolds American Inc. 

/s/ Thomas R. Adams  

Thomas R. Adams, Executive Vice President and 

Chief Financial Officer of Reynolds American Inc.