0001104659-13-068626.txt : 20130909 0001104659-13-068626.hdr.sgml : 20130909 20130909100210 ACCESSION NUMBER: 0001104659-13-068626 CONFORMED SUBMISSION TYPE: 8-K PUBLIC DOCUMENT COUNT: 26 CONFORMED PERIOD OF REPORT: 20130909 ITEM INFORMATION: Regulation FD Disclosure ITEM INFORMATION: Financial Statements and Exhibits FILED AS OF DATE: 20130909 DATE AS OF CHANGE: 20130909 FILER: COMPANY DATA: COMPANY CONFORMED NAME: MERRIMACK PHARMACEUTICALS INC CENTRAL INDEX KEY: 0001274792 STANDARD INDUSTRIAL CLASSIFICATION: PHARMACEUTICAL PREPARATIONS [2834] IRS NUMBER: 000000000 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 8-K SEC ACT: 1934 Act SEC FILE NUMBER: 001-35409 FILM NUMBER: 131084498 BUSINESS ADDRESS: STREET 1: ONE KENDALL SQUARE STREET 2: SUITE B7201 CITY: CAMBRIDGE STATE: MA ZIP: 02139 BUSINESS PHONE: 617-441-1000 MAIL ADDRESS: STREET 1: ONE KENDALL SQUARE STREET 2: SUITE B7201 CITY: CAMBRIDGE STATE: MA ZIP: 02139 8-K 1 a13-20377_18k.htm 8-K

 

 

UNITED STATES
SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

 

 

FORM 8-K

 

CURRENT REPORT
Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

 

Date of Report (Date of earliest event reported): September 9, 2013

 

Merrimack Pharmaceuticals, Inc.

(Exact Name of Registrant as Specified in its Charter)

 

Delaware

 

001-35409

 

04-3210530

(State or Other Jurisdiction
of Incorporation

 

(Commission
File Number)

 

(IRS Employer
Identification No.)

 

One Kendall Square, Suite B7201

Cambridge, MA

 

02139

(Address of Principal Executive Offices)

 

(Zip Code)

 

Registrant’s telephone number, including area code: (617) 441-1000

 

 

(Former Name or Former Address, if Changed Since Last Report)

 

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below):

 

o         Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

 

o                                    Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

 

o                                    Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

 

o                                    Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

 

 

 


 

Item 7.01.  Regulation FD Disclosure.

 

Merrimack Pharmaceuticals, Inc. (the “Company”) from time to time presents and/or distributes to the investment community at various industry and other conferences slide presentations to provide updates and summaries of its business. The Company is posting to the Investors portion of its website at investors.merrimackpharma.com copies of its current corporate slide presentation and factsheet. These slides are attached to this Current Report on Form 8-K as Exhibit 99.1 and Exhibit 99.2. The Company undertakes no obligation to update, supplement or amend the materials attached hereto as Exhibit 99.1 or Exhibit 99.2.

 

In accordance with General Instruction B.2 of Form 8-K, the information in this Item 7.01 of this Current Report on Form 8-K, including Exhibit 99.1 and Exhibit 99.2, shall not be deemed “filed” for the purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise subject to the liabilities of that section, nor shall it be deemed incorporated by reference in any filing under the Exchange Act or the Securities Act of 1933, as amended, except as shall be expressly set forth by reference in such a filing.

 

Item 9.01.  Financial Statements and Exhibits.

 

(d)  Exhibits.

 

See Exhibit Index attached hereto.

 

Forward Looking Statements

 

The attached exhibits contain forward-looking statements that involve substantial risks and uncertainties.  All statements, other than statements of historical facts, contained in these exhibits, including statements regarding our strategy, future operations, future financial position, future revenues, projected costs, prospects, plans and objectives of management, are forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, as amended.  The words “anticipate,” “believe,” “estimate,” “expect,” “intend,” “may,” “plan,” “predict,” “project,” “target,” “potential,” “will,” “would,” “could,” “should,” “continue” and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words.  We may not actually achieve the plans, intentions or expectations disclosed in our forward-looking statements, and you should not place undue reliance on our forward-looking statements.  Actual results or events could differ materially from the plans, intentions and expectations disclosed in the forward-looking statements we make.  These forward-looking statements include, among other things, statements about: our plans to develop and commercialize our most advanced product candidates and companion diagnostics; our ongoing and planned discovery programs, preclinical studies and clinical trials; our anticipated milestones; adequacy of funding for Merrimack’s foreseeable and unforeseeable operating expenses and capital expenditure requirements; and the success or consummation of potential business development activities.  For more information regarding important factors that we believe could cause actual results or events to differ materially from the forward-looking statements that we make, see the “Risk Factors” section of our Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission, or SEC, on August 8, 2013 and other reports we file with the SEC.  Any forward-looking statement contained in these exhibits reflects Merrimack’s views as of the date of the document with respect to future events and Merrimack assumes no obligation to publicly update or revise these forward-looking statements for any reason, or to update the reasons actual results could differ materially from those anticipated in these forward-looking statements, even if new information becomes available in the future, except as otherwise required by applicable law.

 

1


 

SIGNATURE

 

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

 

 

 

MERRIMACK PHARMACEUTICALS, INC.

 

 

 

 

 

Date: September 9, 2013

By:

/s/ Jeffrey A. Munsie

 

 

Jeffrey A. Munsie

 

 

Vice President and General Counsel

 

2


 

EXHIBIT INDEX

 

Exhibit No.

 

Description

 

 

 

99.1

 

Corporate slide presentation of the Company dated September 2013

 

 

 

99.2

 

Factsheet of the Company dated September 2013

 

3

 EX-99.1 2 a13-20377_1ex99d1.htm EX-99.1

Exhibit 99.1

 

GRAPHIC

A Fully Integrated Cancer Company. ^ September 2013

 


GRAPHIC

Forward Looking Statements This presentation contains forward-looking statements that involve substantial risks and uncertainties. All statements, other than statements of historical facts, contained in this presentation, including statements regarding our strategy, future operations, future financial position, future revenues, projected costs, prospects, plans and objectives of management, are forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, as amended. The words “anticipate,” “believe,” “estimate,” “expect,” “intend,” “may,” “plan,” “predict,” “project,” “target,” “potential,” “will,” “would,” “could,” “should,” “continue” and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. We may not actually achieve the plans, intentions or expectations disclosed in our forward-looking statements, and you should not place undue reliance on our forward-looking statements. Actual results or events could differ materially from the plans, intentions and expectations disclosed in the forward-looking statements we make. These forward-looking statements include, among other things, statements about: our plans to develop and commercialize our most advanced product candidates and companion diagnostics; our ongoing and planned discovery programs, preclinical studies and clinical trials; our anticipated milestones; adequacy of funding for Merrimack’s foreseeable and unforeseeable operating expenses and capital expenditure requirements; and the success or consummation of potential business development activities. For more information regarding important factors that we believe could cause actual results or events to differ materially from the forward-looking statements that we make, see the “Risk Factors” section of our Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission, or SEC, on August 8, 2013 and other reports we file with the SEC. Any forward-looking statement contained in this presentation reflects Merrimack’s views as of the date of this presentation with respect to future events and Merrimack assumes no obligation to publicly update or revise these forward-looking statements for any reason, or to update the reasons actual results could differ materially from those anticipated in these forward-looking statements, even if new information becomes available in the future, except as otherwise required by applicable law. 2

 


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Investment Highlights Expertise in multispecific antibodies and targeted nanotherapeutics discovery/development Systems biology-based R&D leverages signaling networks expertise and high throughput computational biology to discover novel therapeutics Six compounds in the clinic and a broad preclinical pipeline MM-121 ErbB3 MAb for solid tumors (Sanofi-partnered) Multiple Phase 2 data readouts expected during Fall 2013 (ovarian, ER/PR+ breast, non-small cell lung) MM-398 irinotecan nanotherapeutic in P3 for pancreatic cancer Cash runway into 2015 3

 


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Candidate Design Target Trial(1) Preclinical Phase 1 Phase 2 Phase 3 MM-121 Monoclonal antibody ErbB3 P1 combo: 48% ORR 70% CBR MM-111 Bispecific antibody ErbB3 & ErbB2 P1 combo: 42% ORR 52% CBR MM-151 Oligoclonal antibody EGFR P1 mono: TBA MM-141 Bispecific tetravalent antibody IGF-1R & ErbB3 P1 mono: TBA MM-131 Multispecific antibody Undisclosed N/A MM-398 Nanotherapeutic targeted irinotecan Topo I inhibition / DNA replication P2 mono: 25% 1 yr OS 5.2 mos median OS 50% DCR MM-302 ErbB2 Ab targeted nanotherapeutic doxorubicin Topo II inhibition / DNA replication P1 mono: 17% ORR 46% CBR MM-310 Antibody targeted nanotherapeutic Undisclosed N/A Signaling Inhibitors Nanotherapeutics Oncology Pipeline (1) Selected trials: MM-121 plus paclitaxel in ErbB2 (HER2) negative breast, ovarian and other gynecological cancers; MM-111 plus multiple anti-cancer therapies in ErbB2 (HER2) positive solid tumors; MM-398 monotherapy in pancreatic cancer; MM-302 monotherapy in ErbB2 (HER2) positive breast cancer 4

 


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Systems Biology Approach to R&D Gene Protein Network Network dynamics govern cell decisions Discovery focused on entire signaling networks, not individual molecules, to increase precision Platform couples high throughput quantitative biology with computing to build predictive models of biological networks Models and simulation drive target discovery, drug and diagnostic engineering, and predictive development Expertise in signaling networks including growth factors, death factors, DNA repair, and cytokines 5

 


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Two Differentiated Drug Technologies 6  MultispecificAb Antibody engineering capabilities Novel antibody designs: bispecific targeting two receptors on same cell tetravalent antibody oligoclonal antibody antibody targeted nano-carriers Targeted Nano-therapeutics A version of Antibody Drug Conjugates with: greater tumor specificity greater duration of exposure thousands fold increase in payload Reduced systemic exposure Broad delivery technology: small molecules, RNAi and gene therapy

 


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MM-398 Second Line Pancreatic Cancer Single arm, MM-398 monotherapy (120 mg/m2 q3w) (data as of May 31, 2012) 12 months – OS 25% 6 months – OS 42% Note: Frontline gemcitabine 12 months – OS 18% 3 months – OS 75% Nanotherapeutic encapsulation of irinotecan Engineered for increased drug deposition, local activation of SN38, and prolonged cytotoxic effects Diagnostic approach: utilize imaging agent to identify responders Taiwan Partner: PharmaEngine Median Overall Survival: 5.2 Months DCR: 50% British Journal of Cancer, August 2013 7

 

MM-398 Increases the Amount of Active Drug Available at the Tumor Site Compared to Other Encapsulated Agents In Vitro t1/2 (h) AUC∞(µg*h/ml) Taxol 7.24 5.85 Abraxane 11.42 4.59 MM-398: Sustained intra-tumor levels t1/2 (h) AUC∞(µg*h/ml) CPT-11 .27 6 MM-398 10.7 2134 Desai et al. (2006) Clin Cancer Res 12, 1317-1324. Abraxane® intra-tumor levels 8

 


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Phase 3 Pancreatic Study Design N=405 patients MM-398 (80 mg/m2 q 2wk) + 5FU/LV 5FU/LV (5/FU 2400 mg/m2 IV over 46 hrs, q2wk + LV 200mg/m2, q2wk) MM-398 (120 mg/m2 q3wk) Trial designed to determine the efficacy and safety of MM-398 alone or in combination with 5FU/LV versus an infusion of 5FU/LV Study design reviewed by US FDA and EMEA; plan to file for mono and/or combination arms with met endpoints Primary endpoint: OS (4.5 mos mono, 6 mos combo vs 3 mos control) NAPOLI-1 (NAnoliPOsomaL Irinotecan) Trial 9 Metastatic Pancreatic Cancer Received prior gemcitabine based therapy RANDOMIZATION

 


GRAPHIC

MM-398 Update 10 Achieved NAPOLI-1 enrollment target of 405 patients in August 2013 Expect top line data from study Q4 2013 or Q1 2014 Study overseen quarterly by independent Data Safety Monitoring Board (DSMB) DSMB’s primary mission is safety; also reviews event rates Has authority to recommend continuation/cessation Last review July 2013: no unexpected toxicities; recommended that study continue

 


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MM-121 Monoclonal Ab to ErbB3 - plays central role in survival and resistance Co-opted by EGFR & ErbB2 Translational focus in clinical program testing pre-specified biomarkers for ErbB3 dependency Goal to stratify patients in next phase clinical studies Global partner: Sanofi MM-121 + paclitaxel Phase 1 study Ovarian and Breast Cancer Patients Presented at ESMO 2012 48% ORR 70% CBR 11

 

MM-121 Translational Focus MM-121 In Vivo Stratification Clinical Hypothesis ErbB3 plays an important role in resistance across tumor types When ErbB3 is active, treatment with 121 provide clinical benefit Translational Strategy Trials designed to assess the activation & prevalence of ErbB3 signaling Testing pre-selected biomarkers validated preclinically & set as a secondary endpoint Unprecedented collection of biopsies/samples (~ 760 patients across 7 global trials) What to Expect Population endpoints will be driven by prevalence – which will vary Opportunity to identify sub-populations and confirm diagnostic hypothesis Merrimack developed a set of biomarkers based on a network analysis understanding that have been preclinically validated on a wide range of tumor models to predict 121 efficacy. 12

 

Phase 2: ER/PR+ Breast Cancer Phase 2: NSCLC wtEGFR Phase 2: ER/PR+ Breast Cancer Phase 2: Ovarian Cancer Phase 2: Triple-negative Breast Cancer Line of Therapy Second line metastatic Second line (no prior EGFR therapy) Neo-adjuvant Second line metastatic Neo-adjuvant Regimen MM-121 + exemestane MM-121 + erlotinib MM-121 + paclitaxel MM-121 + paclitaxel MM-121 + paclitaxel No. of Patients 118 133 100 223 ~100 Fully Enrolled √ √ √ √ Expected Data Read Out Fall 2013 Fall 2013 Top line: Fall 2013; Add’l biomarkers: 2014 Fall 2013 2014 Trial Status Monitoring board recommended study continuation Unlikely to meet primary endpoint; focus on biomarkers Monitoring board recommended study continuation Unlikely to meet primary endpoint; focus on biomarkers Monitoring board recommended study continuation MM-121 Update 13

 


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MM-111 HER2-3 bispecific Ab Engineered against hyperactive HER2/HER3/HRG trimer Superior signaling inhibitor to current agents in preclinical studies Global Phase 2 targeting traditional HER2 adaptation and “non-traditional” HER2 patients Diagnostic approach: Stratifying based on HER2 and other biomarkers Wholly owned 14 MM-111 + Multiple Combinations Phase 1 HER2+ Patients in Multiple Solid Tumors Presented at ESMO 2012 42% ORR 52% CBR

 


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MM-302 ErbB2 Ab targeted nanotherapeutic encapsulation of doxorubicin Engineered for local accumulation & retention (10x) and maximal potency/cell uptake Designed to address cardiotox issues of combinations Diagnostic approach: PET/MRI imaging with copper labeled molecule Wholly owned 15 * * * * * *Prior T-DM1 MM-302 Monotherapy Phase 1 HER2+ Breast Cancer Patients 17% ORR 46% CBR p r o g r e s s i o n f r e e s u r v i v a l ( m o n t h s ) 5 0 0 - 1 0 1 8 5 0 0 - 1 0 1 1 2 0 0 - 1 0 3 3 2 0 0 - 1 0 2 6 3 0 0 - 1 0 3 2 1 0 0 - 1 0 2 1 3 0 0 - 1 0 3 0 1 0 0 - 1 0 2 8 2 0 0 - 1 0 2 3 1 0 0 - 1 0 1 0 1 0 0 - 1 0 1 7 1 0 0 - 1 0 2 7 5 0 0 - 1 0 3 1 3 0 0 - 1 0 3 4 1 0 0 - 1 0 2 4 5 0 0 - 1 0 1 6 3 0 0 - 1 0 2 9 3 0 0 - 1 0 1 2 1 0 0 - 1 0 2 5 5 0 0 - 1 0 2 0 5 0 0 - 1 0 1 9 3 0 0 - 1 0 1 3 2 0 0 - 1 0 2 2 5 0 0 - 1 0 0 9 0 6 12 best change intumor volume (% change) 100 75 50 25 0 - 25 - 50 - 75 - 100

 

MM-151 Oligoclonal antibody combination designed to fully inhibit EGFR Superior signal inhibition, ligand antagonism, and receptor down-regulation in preclinical studies ADCC/CDC (fully human IgG1’s) Targeting wtEGFR LC & CRC Diagnostic approach: biomarker assays testing levels of high vs low affinity ligands Wholly owned 16 MM-151 inhibits high-affinity ligand signaling through EGFR in vitro Presented at World Lung Cancer Conference 2011

 


GRAPHIC

Business Development 17 Pipeline Collaborations Robust platform provides opportunity for product licensing Considering multiple types of transactions Deals covering one or multiple products Deals with regional vs. global commercial players Preference to retain US/EU marketing rights Platform Collaborations Leverage broad platform technologies and knowhow into revenue opportunities to fund R&D Pursuing collaborations in specialty pharmaceuticals Considering arrangements to use our manufacturing capabilities to manufacture drug product on behalf of third party pharmaceutical companies

 


GRAPHIC

Financial Summary 18 Financials Cash runway into 2015 6/30/13 cash and investments: $62M Completed $154M financing in July 2013 $29M equity $125M convertible debt Decrease in cash and investments from Q1 to Q2 of $25M Shares outstanding: ~102M as of 8/31 Sanofi MM-121 Partnership Worldwide co-development $530M in milestones $60M upfront $410M development and regulatory $60M sales and commercial MACK executes Phase 2 Co-promote in US Includes diagnostic Double digit royalties

 


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19 Multiple Data Read Outs Expected Near Term Top line data for four Phase 2 studies for MM-121 including biomarker sub-population Second line ER/PR+ breast cancer Second line ovarian cancer Second line wtEGFR non-small cell lung cancer Neo-adjuvant ER/PR+ breast cancer Phase 1 data for MM-302 Presentation at San Antonio Breast Cancer Symposium Top line data for Phase 3 study of MM-398 in second line pancreatic cancer

 


GRAPHIC

Investment Highlights Expertise in multispecific antibodies and targeted nanotherapeutics discovery/development Systems biology-based R&D leverages signaling networks expertise and high throughput computational biology to discover novel therapeutics Six compounds in the clinic and a broad preclinical pipeline MM-121 ErbB3 MAb for solid tumors (Sanofi-partnered) Multiple Phase 2 data readouts expected during Fall 2013 (ovarian, ER/PR+ breast, non-small cell lung) MM-398 irinotecan nanotherapeutic in P3 for pancreatic cancer Cash runway into 2015 20

 


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A Fully Integrated Cancer Company 21 Eight Candidate Oncology Pipeline 6 clinical programs w/ 20+ clinical indications 2 pre-IND programs and a robust discovery capability Developing companion diagnostics for all oncology products Two Differentiated Drug Technologies Multispecific antibodies Targeted nanotherapeutics Transformative R&D Platform Systems biology-based approach to R&D Integrated engineering, computing, and biology discovery engine Bench to bedside capabilities spanning discovery, development, manufacturing, and clinical

 

 

 EX-99.2 3 a13-20377_1ex99d2.htm EX-99.2

Exhibit 99.2

 

GRAPHIC

Research/Preclinical Phase 1 Phase 2 Phase 3 Signaling Inhibitors (type* – target) MM-121 (MAb – ErbB3) P1 combo data: 48% ORR, 70% CBR(1) MM-111 (BsAb – ErbB3, ErbB2) P1 combo data: 42% ORR, 52% CBR(1) MM-151 (oligoclonal Ab – EGFR) MM-141 (BsTeAb – IGF-1R, ErbB3) MM-131 (multispecific Ab – undisclosed) Nanotherapeutics (capsule – core) MM-398 (nanoliposome – irinotecan) P2 mono data: 25% 1yr OS, 5.2 mos median OS, 50% DCR(1) MM-302 (ErbB2 Ab – doxorubicin) P1 mono: 17% ORR, 46% CBR(1) MM-310 (undisclosed) * Ab = antibody; M = monoclonal; Bs = bispecific; Te = tetravalent 1 (1) Selected trials: MM-121 plus paclitaxel in ErbB2 (HER2) negative breast, ovarian and other gynecological cancers; MM-111 plus multiple anti-cancer therapies in ErbB2 (HER2) positive solid tumors; MM-398 monotherapy in pancreatic cancer; MM-302 monotherapy in ErbB2 (HER2) positive breast cancer Pipeline Update as of September 2013

 


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2 MM-398 MM-121 Pancreatic Cancer Ovarian Cancer Breast Cancer Lung Cancer Phase 3 2 2 2 2 2 Population/ Indication 2nd/3rd-line, metastatic, gemcitabine refractory 2nd-line, metastatic, Pt-resistant/ refractory ER/PR+ metastatic, 2nd-line ER/PR+ neo-adjuvant Triple-negative neo-adjuvant 2nd-line, wild-type EGFR NSCLC; no prior α-EGFR Enrollment 405 (1:1:1 randomized) 223 (2:1) 118 (1:1) 100 (2:1) ~100 (2:1) 133 (2:1) Format Open label Open label Double blind Open label Open label Open label Treatment Arm(s) MM-398 +/- 5FU/LV MM-121 + Paclitaxel MM-121 + Exemestane MM-121 + Paclitaxel MM-121 + Paclitaxel MM-121 + Erlotinib Control Arm 5FU/LV Paclitaxel Placebo + Exemestane Paclitaxel Paclitaxel Erlotinib Biomarker Focus Collecting archived tissue and serum Collecting pre-tx biopsies, archived tissue and serum Collecting archived tissue and serum Collecting pre-treatment biopsies and serum Collecting pre-treatment biopsies and serum Collecting pre-treatment biopsies and serum Primary Endpoint OS (4.5 mos mono, 6 mos combo vs 3 mos control) PFS (6 mos vs 4 mos control) PFS (8 mos vs 4 mos control) pCR (55% vs 35% control) pCR (25% vs 10% control) PFS (5 mos vs 2.5 mos control) Anticipated Timing Q4 2013 – Q1 2014 Fall 2013 Fall 2013 Top-line: Fall 2013; Add’l biomarkers: 2014 2014 Fall 2013 Trial Status Passed DSMB safety review Unlikely to meet primary endpoint; biomarker focus Monitoring boards recommended study continuation Monitoring boards recommended study continuation Monitoring boards recommended study continuation Unlikely to meet primary endpoint; biomarker focus Late Stage Trial Metrics as of September 2013

 

 

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