Stockholders' Equity - Stock Options, Restricted Stock, RSUs, , Offering (Details) - USD ($) $ / shares in Units, $ in Thousands		12 Months Ended
	Mar. 29, 2022	Dec. 31, 2023	Dec. 31, 2022
Stockholders' Equity
Total compensation cost		$ 15,563	$ 14,890
Issuance of common stock (in shares)		3,700,000
Proceeds from equity offerings, net of offering costs		$ 25,800
Maximum percentage of beneficial ownership for exercise of Pre-funded Warrants			9.99%
Maximum percentage increase or decrease of beneficial ownership for exercise of Pre-funded Warrants			19.99%
Additional Disclosures
Weighted average remaining contractual term		7 years 6 months
Market value per share		$ 7.17
Unrecognized compensation expense
Unrecognized compensation expense, unvested stock options		$ 15,600
Unrecognized compensation expense, restricted stock units		6,400
Unrecognized compensation expense		$ 21,953
Common Stock
Stock Options
Exercised (in shares)		(126,735)	(238,312)
Public Offering.
Stockholders' Equity
Issuance of common stock (in shares)			12,421,053
Number of pre-funded warrants (in shares)			2,105,264
Proceeds from equity offerings, net of offering costs			$ 64,500
Ovid License Agreement
Stockholders' Equity
Issuance of common stock (in shares)	123,255
Recognition in 2024
Unrecognized compensation expense
Unrecognized compensation expense		$ 12,690
Recognition in 2025
Unrecognized compensation expense
Unrecognized compensation expense		7,348
Recognition in 2026
Unrecognized compensation expense
Unrecognized compensation expense		1,549
Recognition in 2027
Unrecognized compensation expense
Unrecognized compensation expense		$ 366
Employee Stock Option
Stock Options
Outstanding at the beginning of the period (in shares)		5,730,219	4,738,855
Granted (in shares)		2,117,451	2,026,981
Exercised (in shares)		(126,735)	(238,312)
Forfeited (in shares)		(267,239)	(415,816)
Expired (in shares)		(288,715)	(381,489)
Outstanding at the end of the period (in shares)		7,164,981	5,730,219
Exercisable at the end of the period (in shares)		4,620,748
Weighted-Average Exercise Price Per Share
Outstanding at the beginning of the period (in dollars per share)		$ 10.87	$ 12.23
Granted (in dollars per share)		6.43	8.77
Exercised (in dollars per share)		6.35	7.52
Forfeited (in dollars per share)		8.34	10.49
Expired (in dollars per share)		13.34	14.61
Outstanding at the end of the period (in dollars per share)		9.64	10.87
Exercisable at the end of the period (in dollars per share)		$ 10.64
Aggregate Intrinsic Value
Outstanding at the end of the period		$ 17,854
Exercisable at the end of the period		$ 9,292
Additional Disclosures
Weighted average remaining contractual term exercisable		6 years 10 months 24 days
Market value per share		$ 10.87
Weighted average grant date fair value (in dollars per share)		$ 5.20	$ 7.00
Weighted-average assumptions
Expected annual dividend yield (as a percent)		0.00%	0.00%
Employee Stock Option | Minimum
Weighted-average assumptions
Expected stock price volatility (as a percent)		99.00%	103.00%
Expected term of options		5 years 3 months 18 days	5 years 8 months 12 days
Risk-free interest rate (as a percent)		3.35%	1.65%
Employee Stock Option | Maximum
Stockholders' Equity
Vesting period		4 years
Weighted-average assumptions
Expected stock price volatility (as a percent)		104.00%	116.00%
Expected term of options		6 years 1 month 6 days	6 years 6 months
Risk-free interest rate (as a percent)		4.82%	4.46%
Expected annual dividend yield (as a percent)		0.00%	0.00%
Restricted Stock and Restricted Stock Units
Shares
Restricted stock units outstanding at the beginning of the period (in shares)		671,976	26,025
Granted (in shares)		1,004,310	809,028
Vested (in shares)		(262,819)	(37,450)
Forfeited (in shares)		(141,573)	(125,627)
Restricted stock units outstanding at the end of the period (in shares		1,271,894	671,976
Weighted-average Grant Date Fair Value
Restricted stock units outstanding at the beginning of the period (in dollars per shares)		$ 8.39	$ 12.75
Granted (in dollars per share)		6.17	8.49
Vested (in dollars per share)		8.26	11.19
Forfeited (in dollars per share)		6.61	9.04
Restricted stock units outstanding at the end of the period (in dollars per shares)		$ 6.86	$ 8.39
Restricted common stock | Maximum
Stockholders' Equity
Vesting period		2 years
Restricted Stock Units (RSUs)
Shares
Restricted stock units outstanding at the end of the period (in shares		1,271,894
2005 Plan | Employee Stock Option
Stock Options
Outstanding at the end of the period (in shares)		577
2005 Plan | Employee Stock Option | Maximum
Stockholders' Equity
Contractual life		10 years
2014 Plan | Employee Stock Option
Stock Options
Outstanding at the end of the period (in shares)		4,924,969
2014 Plan | Employee Stock Option | Maximum
Stockholders' Equity
Contractual life		10 years
2014 Plan | Restricted common stock
Shares
Restricted stock units outstanding at the end of the period (in shares		0
2014 Plan | Restricted Stock Units (RSUs)
Stockholders' Equity
Vesting period		4 years
Shares
Granted (in shares)		1,004,310
Restricted stock units outstanding at the end of the period (in shares		1,257,019
Research and development.
Stockholders' Equity
Total compensation cost		$ 5,806	$ 5,364
Selling, general and administrative
Stockholders' Equity
Total compensation cost		$ 9,757	$ 9,526