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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 TPiqUuMMDF5LHRxwr0v1ns4hwE5dffqNQT8GwDprq3V/45usDl4ihd/asNmlXDLv
 80Jru8SHkf5dT8dnKINbUA==

<SEC-DOCUMENT>0001192482-10-000031.txt : 20100308
<SEC-HEADER>0001192482-10-000031.hdr.sgml : 20100308
<ACCEPTANCE-DATETIME>20100308132052
ACCESSION NUMBER:		0001192482-10-000031
CONFORMED SUBMISSION TYPE:	D
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
FILED AS OF DATE:		20100308
DATE AS OF CHANGE:		20100308
EFFECTIVENESS DATE:		20100308

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			COLLEGIUM PHARMACEUTICAL INC
		CENTRAL INDEX KEY:			0001267565
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		D
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-59559
		FILM NUMBER:		10663004

	BUSINESS ADDRESS:	
		STREET 1:		400 HIGHLAND CORPORATE DRIVE
		CITY:			CUMBERLAND
		STATE:			RI
		ZIP:			02864
		BUSINESS PHONE:		401-762-2000

	MAIL ADDRESS:	
		STREET 1:		400 HIGHLAND CORPORATE DRIVE
		CITY:			CUMBERLAND
		STATE:			RI
		ZIP:			02864
</SEC-HEADER>
<DOCUMENT>
<TYPE>D
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0603</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001267565</cik>
        <entityName>COLLEGIUM PHARMACEUTICAL INC</entityName>
        <issuerAddress>
            <street1>400 HIGHLAND CORPORATE DRIVE</street1>
            <city>CUMBERLAND</city>
            <stateOrCountry>RI</stateOrCountry>
            <zipCode>02864</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>401-762-2000</issuerPhoneNumber>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <issuerPreviousNameList>
            <value>None</value>
        </issuerPreviousNameList>
        <edgarPreviousNameList>
            <value>None</value>
        </edgarPreviousNameList>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Michael</firstName>
                <lastName>Heffernan</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>400 Highland Corporate Drive</street1>
                <city>Cumberland</city>
                <stateOrCountry>RI</stateOrCountry>
                <zipCode>02864</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Steven</firstName>
                <middleName>N.</middleName>
                <lastName>Tannenbaum</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>400 Highland Corporate Drive</street1>
                <city>Cumberland</city>
                <stateOrCountry>RI</stateOrCountry>
                <zipCode>02864</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Patrick</firstName>
                <lastName>Heron</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>400 Highland Corporate Drive</street1>
                <city>Cumberland</city>
                <stateOrCountry>RI</stateOrCountry>
                <zipCode>02864</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Patrick</firstName>
                <lastName>Fortune</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>400 Highland Corporate Drive</street1>
                <city>Cumberland</city>
                <stateOrCountry>RI</stateOrCountry>
                <zipCode>02864</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Matthew</firstName>
                <lastName>Strobeck</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>400 Highland Corporate Drive</street1>
                <city>Cumberland</city>
                <stateOrCountry>RI</stateOrCountry>
                <zipCode>02864</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Pharmaceuticals</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2010-03-01</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isDebtType>true</isDebtType>
            <isOptionToAcquireType>true</isOptionToAcquireType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>2500000</totalOfferingAmount>
            <totalAmountSold>1000000</totalAmountSold>
            <totalRemaining>1500000</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>7</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>COLLEGIUM PHARMACEUTICAL INC</issuerName>
                <signatureName>/s/ Steven N. Tennenbaum</signatureName>
                <nameOfSigner>Steven N. Tannenbaum</nameOfSigner>
                <signatureTitle>Executive Vice President</signatureTitle>
                <signatureDate>2010-03-08</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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