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The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
2seventy bio, Inc. COM 901384107   9,790,302 2,497,526 SH   SOLE   2,497,526 0 0
Aadi Bioscience, Inc. COM 00032Q104   4,791,252 989,928 SH   SOLE   989,928 0 0
AbCellera Biologics Inc. COM 00288U106   95,511,286 20,763,323 SH   SOLE   20,763,323 0 0
ACADIA Pharmaceuticals Inc. COM 004225108   893,298,514 42,864,612 SH   SOLE   42,864,612 0 0
Achilles Therapeutics plc SPONSORED ADS 00449L102   2,326,750 2,557,149 SH   SOLE   2,557,149 0 0
Adaptimmune Therapeutics plc SPONSORED ADR 00653A107   8,556,040 10,969,282 SH   SOLE   10,969,282 0 0
Aerovate Therapeutics, Inc. COM 008064107   26,644,410 1,963,479 SH   SOLE   1,963,479 0 0
Affimed N.V. COM N01045108   2,126,007 4,448,644 SH   SOLE   4,448,644 0 0
Akero Therapeutics, Inc. COM 00973Y108   119,792,559 2,368,378 SH   SOLE   2,368,378 0 0
Alector, Inc. COM 014442107   6,252,234 964,851 SH   SOLE   964,851 0 0
Aligos Therapeutics, Inc. COM 01626L105   1,551,071 2,076,400 SH   SOLE   2,076,400 0 0
AnaptysBio, Inc. COM 032724106   1,907,298 106,197 SH   SOLE   106,197 0 0
argenx SE SPONSORED ADR 04016X101   74,341,830 151,215 SH   SOLE   151,215 0 0
ARS Pharmaceuticals, Inc. COM 82835W108   7,584,385 2,006,451 SH   SOLE   2,006,451 0 0
Arvinas, Inc. COM 04335A105   8,120,767 413,481 SH   SOLE   413,481 0 0
Athira Pharma, Inc. COM 04746L104   6,370,690 3,153,807 SH   SOLE   3,153,807 0 0
Atreca, Inc. CL A COM 04965G109   922,050 3,532,760 SH   SOLE   3,532,760 0 0
Avidity Biosciences, Inc. COM 05370A108   1,061,294 166,347 SH   SOLE   166,347 0 0
BeiGene, Ltd. SPONSORED ADR 07725L102   2,098,884,503 11,668,897 SH   SOLE   11,668,897 0 0
Bicycle Therapeutics plc SPONSORED ADS 088786108   16,952,223 843,814 SH   SOLE   843,814 0 0
BioCryst Pharmaceuticals, Inc. COM 09058V103   89,992,591 12,710,818 SH   SOLE   12,710,818 0 0
BioMarin Pharmaceutical Inc. COM 09061G101   337,130,743 3,810,248 SH   SOLE   3,810,248 0 0
Biomea Fusion, Inc. COM 09077A106   29,019,138 2,108,949 SH   SOLE   2,108,949 0 0
bluebird bio, Inc. COM 09609G100   7,599,134 2,499,715 SH   SOLE   2,499,715 0 0
Cabaletta Bio, Inc. COM 12674W109   24,260,680 1,594,000 SH   SOLE   1,594,000 0 0
Celcuity Inc. COM 15102K100   4,894,269 535,478 SH   SOLE   535,478 0 0
Century Therapeutics, Inc. COM 15673T100   2,298,680 1,149,340 SH   SOLE   1,149,340 0 0
Cerus Corporation COM 157085101   27,927,992 17,239,501 SH   SOLE   17,239,501 0 0
Cogent Biosciences, Inc. COM 19240Q201   12,606,419 1,292,966 SH   SOLE   1,292,966 0 0
Compass Therapeutics, Inc. COM 20454B104   3,068,531 1,557,630 SH   SOLE   1,557,630 0 0
Day One Biopharmaceuticals, Inc. COM 23954D109   12,270,000 1,000,000 SH   SOLE   1,000,000 0 0
DBV Technologies S.A. SPONSORED ADR 23306J101   19,875,399 14,614,264 SH   SOLE   14,614,264 0 0
Denali Therapeutics Inc. COM 24823R105   47,284,022 2,292,003 SH   SOLE   2,292,003 0 0
Design Therapeutics, Inc. COM 25056L103   3,540,000 1,500,000 SH   SOLE   1,500,000 0 0
Edgewise Therapeutics, Inc. COM 28036F105   6,014,775 1,049,699 SH   SOLE   1,049,699 0 0
Entrada Therapeutics, Inc. COM 29384C108   76,879,940 4,865,819 SH   SOLE   4,865,819 0 0
Foghorn Therapeutics Inc. COM 344174107   225,135 45,027 SH   SOLE   45,027 0 0
Genetron Holdings Limited ADS 37186H100   369,754 455,306 SH   SOLE   455,306 0 0
Geron Corporation COM 374163103   6,489,795 3,061,224 SH   SOLE   3,061,224 0 0
Gracell Biotechnologies Inc. SPONSORED ADS 38406L103   2,880,000 1,000,000 SH   SOLE   1,000,000 0 0
Heron Therapeutics, Inc. COM 427746102   8,375,628 8,131,678 SH   SOLE   8,131,678 0 0
HOOKIPA Pharma Inc. COM 43906K100   4,968,285 8,065,398 SH   SOLE   8,065,398 0 0
IDEAYA Biosciences, Inc. COM 45166A102   28,656,079 1,062,123 SH   SOLE   1,062,123 0 0
IGM Biosciences, Inc. COM 449585108   26,367,329 3,157,764 SH   SOLE   3,157,764 0 0
Immatics N.V. SHS N44445109   65,320,649 5,640,816 SH   SOLE   5,640,816 0 0
Immunocore Holdings plc ADS 45258D105   130,825,939 2,520,731 SH   SOLE   2,520,731 0 0
Immunovant, Inc. COM 45258J102   16,316,096 425,009 SH   SOLE   425,009 0 0
Incyte Corporation COM 45337C102   2,090,035,758 36,178,566 SH   SOLE   36,178,566 0 0
Insmed Incorporated COM PAR $.01 457669307   8,660,750 343,000 SH   SOLE   343,000 0 0
Instil Bio, Inc. COM 45783C101   2,013,481 4,704,395 SH   SOLE   4,704,395 0 0
Invitae Corporation COM 46185L103   1,067,903 1,764,546 SH   SOLE   1,764,546 0 0
iTeos Therapeutics, Inc. COM 46565G104   1,646,289 150,346 SH   SOLE   150,346 0 0
KALA BIO, Inc. COM 483119202   2,372,856 266,613 SH   SOLE   266,613 0 0
Kiniksa Pharmaceuticals, Ltd. COM CL A G5269C101   48,802,352 2,809,577 SH   SOLE   2,809,577 0 0
Kodiak Sciences Inc. COM 50015M109   31,158,882 17,310,490 SH   SOLE   17,310,490 0 0
Krystal Biotech, Inc. COM 501147102   19,712,344 169,934 SH   SOLE   169,934 0 0
Kymera Therapeutics, Inc. COM 501575104   66,030,560 4,750,400 SH   SOLE   4,750,400 0 0
Leap Therapeutics, Inc. COM 52187K200   1,617,602 1,172,175 SH   SOLE   1,172,175 0 0
Madrigal Pharmaceuticals, Inc. COM 558868105   225,648,303 1,545,113 SH   SOLE   1,545,113 0 0
Mersana Therapeutics, Inc. COM 59045L106   1,379,366 1,086,115 SH   SOLE   1,086,115 0 0
Mirati Therapeutics, Inc. COM 60468T105   61,410,191 1,409,784 SH   SOLE   1,409,784 0 0
Mirum Pharmaceuticals, Inc. COM 604749101   6,019,042 190,476 SH   SOLE   190,476 0 0
Monte Rosa Therapeutics, Inc. COM 61225M102   23,548,095 4,916,095 SH   SOLE   4,916,095 0 0
Morphic Holding, Inc. COM 61775R105   4,943,978 215,800 SH   SOLE   215,800 0 0
Natera, Inc. COM 632307104   4,425,000 100,000 SH   SOLE   100,000 0 0
Neoleukin Therapeutics, Inc. COM 64049K203   4,824,585 1,221,414 SH   SOLE   1,221,414 0 0
Nurix Therapeutics, Inc. COM 67080M103   30,513,503 3,882,125 SH   SOLE   3,882,125 0 0
Opthea Limited SPONSORED ADS 68386J208   4,687,532 2,690,891 SH   SOLE   2,690,891 0 0
Pacific Biosciences of California, Inc. COM 69404D108   9,416,980 1,127,782 SH   SOLE   1,127,782 0 0
Perspective Therapeutics, Inc. COM 46489V104   2,090,987 7,639,703 SH   SOLE   7,639,703 0 0
PMV Pharmaceuticals, Inc. COM 69353Y103   1,977,227 322,024 SH   SOLE   322,024 0 0
POINT Biopharma Global Inc. COM 730541109   1,667,287 249,968 SH   SOLE   249,968 0 0
Praxis Precision Medicines, Inc. COM 74006W108   3,214,655 1,879,915 SH   SOLE   1,879,915 0 0
Prelude Therapeutics Inc. COM 74065P101   31,282,616 10,123,824 SH   SOLE   10,123,824 0 0
Prime Medicine, Inc. COM 74168J101   9,811,566 1,028,466 SH   SOLE   1,028,466 0 0
Protara Therapeutics, Inc. COM STK 74365U107   333,451 199,671 SH   SOLE   199,671 0 0
Relay Therapeutics, Inc. COM 75943R102   9,756,584 1,160,117 SH   SOLE   1,160,117 0 0
Replimune Group, Inc. COM 76029N106   78,334,371 4,578,280 SH   SOLE   4,578,280 0 0
Revolution Medicines, Inc. COM 76155X100   74,500,526 2,691,493 SH   SOLE   2,691,493 0 0
Rhythm Pharmaceuticals, Inc. COM 76243J105   153,651,351 6,702,349 SH   SOLE   6,702,349 0 0
Roivant Sciences Ltd. SHS G76279101   138,725,357 11,877,171 SH   SOLE   11,877,171 0 0
Sagimet Biosciences Inc. COM 786700104   7,175,159 815,359 SH   SOLE   815,359 0 0
Sana Biotechnology, Inc. COM 799566104   7,740,000 2,000,000 SH   SOLE   2,000,000 0 0
Seagen Inc. COM 81181C104   9,452,165,468 44,554,162 SH   SOLE   44,554,162 0 0
Sera Prognostics, Inc. CLASS A COM 81749D107   2,818,536 1,515,342 SH   SOLE   1,515,342 0 0
SpringWorks Therapeutics, Inc. COM 85205L107   69,356,440 2,999,846 SH   SOLE   2,999,846 0 0
Stoke Therapeutics, Inc. COM 86150R107   5,854,505 1,485,915 SH   SOLE   1,485,915 0 0
Summit Therapeutics Inc. COM 86627T108   5,872,685 3,140,473 SH   SOLE   3,140,473 0 0
Surrozen, Inc. W EXP 8/11/2026 86889P117   34,250 833,333 SH   SOLE   833,333 0 0
Talis Biomedical Corporation COM 87424L207   2,933,024 508,323 SH   SOLE   508,323 0 0
Tango Therapeutics, Inc. COM 87583X109   8,445,000 750,000 SH   SOLE   750,000 0 0
Taysha Gene Therapies, Inc. COM SHS 877619106   7,915,029 2,504,756 SH   SOLE   2,504,756 0 0
TScan Therapeutics, Inc. COM 89854M101   7,129,068 2,784,792 SH   SOLE   2,784,792 0 0
Ultragenyx Pharmaceutical Inc. COM 90400D108   48,717,401 1,366,547 SH   SOLE   1,366,547 0 0
Vaxcyte, Inc. COM 92243G108   2,492,157 48,885 SH   SOLE   48,885 0 0
Verve Therapeutics, Inc. COM 92539P101   18,783,188 1,416,530 SH   SOLE   1,416,530 0 0
Vor Biopharma Inc. COM 929033108   1,343,758 633,848 SH   SOLE   633,848 0 0
Xencor, Inc. COM 98401F105   2,481,009 123,127 SH   SOLE   123,127 0 0
Xenon Pharmaceuticals Inc. COM 98420N105   25,675,988 751,639 SH   SOLE   751,639 0 0
Invitae Corporation Note 1.5% 4/1/2028 46185LAD5   130,372,500 300,000,000 PRN   SOLE   300,000,000 0 0
Invitae Corporation Series A 4.5% 3/15/2028 46185LAH6   6,208,368 9,274,000 PRN   SOLE   9,274,000 0 0