0001104659-23-118157.txt : 20231114 0001104659-23-118157.hdr.sgml : 20231114 20231114162534 ACCESSION NUMBER: 0001104659-23-118157 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20230930 FILED AS OF DATE: 20231114 DATE AS OF CHANGE: 20231114 EFFECTIVENESS DATE: 20231114 FILER: COMPANY DATA: COMPANY CONFORMED NAME: BAKER BROS. ADVISORS LP CENTRAL INDEX KEY: 0001263508 IRS NUMBER: 134093645 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-10519 FILM NUMBER: 231406824 BUSINESS ADDRESS: STREET 1: 860 WASHINGTON STREET STREET 2: 3RD FLOOR CITY: NEW YORK STATE: NY ZIP: 10014 BUSINESS PHONE: 2123395600 MAIL ADDRESS: STREET 1: 860 WASHINGTON STREET STREET 2: 3RD FLOOR CITY: NEW YORK STATE: NY ZIP: 10014 FORMER COMPANY: FORMER CONFORMED NAME: BAKER BROS ADVISORS LLC DATE OF NAME CHANGE: 20030911 13F-HR 1 primary_doc.xml X0202 13F-HR LIVE false false false 0001263508 XXXXXXXX 09-30-2023 09-30-2023 false BAKER BROS. ADVISORS LP

860 WASHINGTON STREET 3RD FLOOR NEW YORK NY 10014

13F HOLDINGS REPORT 028-10519 000158149 801-73446 N Alexandra Toohey 212-339-5690 /s/ Alexandra Toohey New York NY 11-14-2023 0 101 17351037330 INFORMATION TABLE 2 infotable.xml 2seventy bio, Inc. COM 901384107 9790302 2497526 SH SOLE 2497526 0 0 Aadi Bioscience, Inc. COM 00032Q104 4791252 989928 SH SOLE 989928 0 0 AbCellera Biologics Inc. COM 00288U106 95511286 20763323 SH SOLE 20763323 0 0 ACADIA Pharmaceuticals Inc. COM 004225108 893298514 42864612 SH SOLE 42864612 0 0 Achilles Therapeutics plc SPONSORED ADS 00449L102 2326750 2557149 SH SOLE 2557149 0 0 Adaptimmune Therapeutics plc SPONSORED ADR 00653A107 8556040 10969282 SH SOLE 10969282 0 0 Aerovate Therapeutics, Inc. COM 008064107 26644410 1963479 SH SOLE 1963479 0 0 Affimed N.V. COM N01045108 2126007 4448644 SH SOLE 4448644 0 0 Akero Therapeutics, Inc. COM 00973Y108 119792559 2368378 SH SOLE 2368378 0 0 Alector, Inc. COM 014442107 6252234 964851 SH SOLE 964851 0 0 Aligos Therapeutics, Inc. COM 01626L105 1551071 2076400 SH SOLE 2076400 0 0 AnaptysBio, Inc. COM 032724106 1907298 106197 SH SOLE 106197 0 0 argenx SE SPONSORED ADR 04016X101 74341830 151215 SH SOLE 151215 0 0 ARS Pharmaceuticals, Inc. COM 82835W108 7584385 2006451 SH SOLE 2006451 0 0 Arvinas, Inc. COM 04335A105 8120767 413481 SH SOLE 413481 0 0 Athira Pharma, Inc. COM 04746L104 6370690 3153807 SH SOLE 3153807 0 0 Atreca, Inc. CL A COM 04965G109 922050 3532760 SH SOLE 3532760 0 0 Avidity Biosciences, Inc. COM 05370A108 1061294 166347 SH SOLE 166347 0 0 BeiGene, Ltd. SPONSORED ADR 07725L102 2098884503 11668897 SH SOLE 11668897 0 0 Bicycle Therapeutics plc SPONSORED ADS 088786108 16952223 843814 SH SOLE 843814 0 0 BioCryst Pharmaceuticals, Inc. COM 09058V103 89992591 12710818 SH SOLE 12710818 0 0 BioMarin Pharmaceutical Inc. COM 09061G101 337130743 3810248 SH SOLE 3810248 0 0 Biomea Fusion, Inc. COM 09077A106 29019138 2108949 SH SOLE 2108949 0 0 bluebird bio, Inc. COM 09609G100 7599134 2499715 SH SOLE 2499715 0 0 Cabaletta Bio, Inc. COM 12674W109 24260680 1594000 SH SOLE 1594000 0 0 Celcuity Inc. COM 15102K100 4894269 535478 SH SOLE 535478 0 0 Century Therapeutics, Inc. COM 15673T100 2298680 1149340 SH SOLE 1149340 0 0 Cerus Corporation COM 157085101 27927992 17239501 SH SOLE 17239501 0 0 Cogent Biosciences, Inc. COM 19240Q201 12606419 1292966 SH SOLE 1292966 0 0 Compass Therapeutics, Inc. COM 20454B104 3068531 1557630 SH SOLE 1557630 0 0 Day One Biopharmaceuticals, Inc. COM 23954D109 12270000 1000000 SH SOLE 1000000 0 0 DBV Technologies S.A. SPONSORED ADR 23306J101 19875399 14614264 SH SOLE 14614264 0 0 Denali Therapeutics Inc. COM 24823R105 47284022 2292003 SH SOLE 2292003 0 0 Design Therapeutics, Inc. COM 25056L103 3540000 1500000 SH SOLE 1500000 0 0 Edgewise Therapeutics, Inc. COM 28036F105 6014775 1049699 SH SOLE 1049699 0 0 Entrada Therapeutics, Inc. COM 29384C108 76879940 4865819 SH SOLE 4865819 0 0 Foghorn Therapeutics Inc. COM 344174107 225135 45027 SH SOLE 45027 0 0 Genetron Holdings Limited ADS 37186H100 369754 455306 SH SOLE 455306 0 0 Geron Corporation COM 374163103 6489795 3061224 SH SOLE 3061224 0 0 Gracell Biotechnologies Inc. SPONSORED ADS 38406L103 2880000 1000000 SH SOLE 1000000 0 0 Heron Therapeutics, Inc. COM 427746102 8375628 8131678 SH SOLE 8131678 0 0 HOOKIPA Pharma Inc. COM 43906K100 4968285 8065398 SH SOLE 8065398 0 0 IDEAYA Biosciences, Inc. COM 45166A102 28656079 1062123 SH SOLE 1062123 0 0 IGM Biosciences, Inc. COM 449585108 26367329 3157764 SH SOLE 3157764 0 0 Immatics N.V. SHS N44445109 65320649 5640816 SH SOLE 5640816 0 0 Immunocore Holdings plc ADS 45258D105 130825939 2520731 SH SOLE 2520731 0 0 Immunovant, Inc. COM 45258J102 16316096 425009 SH SOLE 425009 0 0 Incyte Corporation COM 45337C102 2090035758 36178566 SH SOLE 36178566 0 0 Insmed Incorporated COM PAR $.01 457669307 8660750 343000 SH SOLE 343000 0 0 Instil Bio, Inc. COM 45783C101 2013481 4704395 SH SOLE 4704395 0 0 Invitae Corporation COM 46185L103 1067903 1764546 SH SOLE 1764546 0 0 iTeos Therapeutics, Inc. COM 46565G104 1646289 150346 SH SOLE 150346 0 0 KALA BIO, Inc. COM 483119202 2372856 266613 SH SOLE 266613 0 0 Kiniksa Pharmaceuticals, Ltd. COM CL A G5269C101 48802352 2809577 SH SOLE 2809577 0 0 Kodiak Sciences Inc. COM 50015M109 31158882 17310490 SH SOLE 17310490 0 0 Krystal Biotech, Inc. COM 501147102 19712344 169934 SH SOLE 169934 0 0 Kymera Therapeutics, Inc. COM 501575104 66030560 4750400 SH SOLE 4750400 0 0 Leap Therapeutics, Inc. COM 52187K200 1617602 1172175 SH SOLE 1172175 0 0 Madrigal Pharmaceuticals, Inc. COM 558868105 225648303 1545113 SH SOLE 1545113 0 0 Mersana Therapeutics, Inc. COM 59045L106 1379366 1086115 SH SOLE 1086115 0 0 Mirati Therapeutics, Inc. COM 60468T105 61410191 1409784 SH SOLE 1409784 0 0 Mirum Pharmaceuticals, Inc. COM 604749101 6019042 190476 SH SOLE 190476 0 0 Monte Rosa Therapeutics, Inc. COM 61225M102 23548095 4916095 SH SOLE 4916095 0 0 Morphic Holding, Inc. COM 61775R105 4943978 215800 SH SOLE 215800 0 0 Natera, Inc. COM 632307104 4425000 100000 SH SOLE 100000 0 0 Neoleukin Therapeutics, Inc. COM 64049K203 4824585 1221414 SH SOLE 1221414 0 0 Nurix Therapeutics, Inc. COM 67080M103 30513503 3882125 SH SOLE 3882125 0 0 Opthea Limited SPONSORED ADS 68386J208 4687532 2690891 SH SOLE 2690891 0 0 Pacific Biosciences of California, Inc. COM 69404D108 9416980 1127782 SH SOLE 1127782 0 0 Perspective Therapeutics, Inc. COM 46489V104 2090987 7639703 SH SOLE 7639703 0 0 PMV Pharmaceuticals, Inc. COM 69353Y103 1977227 322024 SH SOLE 322024 0 0 POINT Biopharma Global Inc. COM 730541109 1667287 249968 SH SOLE 249968 0 0 Praxis Precision Medicines, Inc. COM 74006W108 3214655 1879915 SH SOLE 1879915 0 0 Prelude Therapeutics Inc. COM 74065P101 31282616 10123824 SH SOLE 10123824 0 0 Prime Medicine, Inc. COM 74168J101 9811566 1028466 SH SOLE 1028466 0 0 Protara Therapeutics, Inc. COM STK 74365U107 333451 199671 SH SOLE 199671 0 0 Relay Therapeutics, Inc. COM 75943R102 9756584 1160117 SH SOLE 1160117 0 0 Replimune Group, Inc. COM 76029N106 78334371 4578280 SH SOLE 4578280 0 0 Revolution Medicines, Inc. COM 76155X100 74500526 2691493 SH SOLE 2691493 0 0 Rhythm Pharmaceuticals, Inc. COM 76243J105 153651351 6702349 SH SOLE 6702349 0 0 Roivant Sciences Ltd. SHS G76279101 138725357 11877171 SH SOLE 11877171 0 0 Sagimet Biosciences Inc. COM 786700104 7175159 815359 SH SOLE 815359 0 0 Sana Biotechnology, Inc. COM 799566104 7740000 2000000 SH SOLE 2000000 0 0 Seagen Inc. COM 81181C104 9452165468 44554162 SH SOLE 44554162 0 0 Sera Prognostics, Inc. CLASS A COM 81749D107 2818536 1515342 SH SOLE 1515342 0 0 SpringWorks Therapeutics, Inc. COM 85205L107 69356440 2999846 SH SOLE 2999846 0 0 Stoke Therapeutics, Inc. COM 86150R107 5854505 1485915 SH SOLE 1485915 0 0 Summit Therapeutics Inc. COM 86627T108 5872685 3140473 SH SOLE 3140473 0 0 Surrozen, Inc. W EXP 8/11/2026 86889P117 34250 833333 SH SOLE 833333 0 0 Talis Biomedical Corporation COM 87424L207 2933024 508323 SH SOLE 508323 0 0 Tango Therapeutics, Inc. COM 87583X109 8445000 750000 SH SOLE 750000 0 0 Taysha Gene Therapies, Inc. COM SHS 877619106 7915029 2504756 SH SOLE 2504756 0 0 TScan Therapeutics, Inc. COM 89854M101 7129068 2784792 SH SOLE 2784792 0 0 Ultragenyx Pharmaceutical Inc. COM 90400D108 48717401 1366547 SH SOLE 1366547 0 0 Vaxcyte, Inc. COM 92243G108 2492157 48885 SH SOLE 48885 0 0 Verve Therapeutics, Inc. COM 92539P101 18783188 1416530 SH SOLE 1416530 0 0 Vor Biopharma Inc. COM 929033108 1343758 633848 SH SOLE 633848 0 0 Xencor, Inc. COM 98401F105 2481009 123127 SH SOLE 123127 0 0 Xenon Pharmaceuticals Inc. COM 98420N105 25675988 751639 SH SOLE 751639 0 0 Invitae Corporation Note 1.5% 4/1/2028 46185LAD5 130372500 300000000 PRN SOLE 300000000 0 0 Invitae Corporation Series A 4.5% 3/15/2028 46185LAH6 6208368 9274000 PRN SOLE 9274000 0 0