0001104659-23-091343.txt : 20230814 0001104659-23-091343.hdr.sgml : 20230814 20230814161327 ACCESSION NUMBER: 0001104659-23-091343 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20230630 FILED AS OF DATE: 20230814 DATE AS OF CHANGE: 20230814 EFFECTIVENESS DATE: 20230814 FILER: COMPANY DATA: COMPANY CONFORMED NAME: BAKER BROS. ADVISORS LP CENTRAL INDEX KEY: 0001263508 IRS NUMBER: 134093645 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-10519 FILM NUMBER: 231170277 BUSINESS ADDRESS: STREET 1: 860 WASHINGTON STREET STREET 2: 3RD FLOOR CITY: NEW YORK STATE: NY ZIP: 10014 BUSINESS PHONE: 2123395600 MAIL ADDRESS: STREET 1: 860 WASHINGTON STREET STREET 2: 3RD FLOOR CITY: NEW YORK STATE: NY ZIP: 10014 FORMER COMPANY: FORMER CONFORMED NAME: BAKER BROS ADVISORS LLC DATE OF NAME CHANGE: 20030911 13F-HR 1 primary_doc.xml X0202 13F-HR LIVE false false false 0001263508 XXXXXXXX 06-30-2023 06-30-2023 false BAKER BROS. ADVISORS LP

860 WASHINGTON STREET 3RD FLOOR NEW YORK NY 10014

13F HOLDINGS REPORT 028-10519 000158149 801-73446 N Alexandra Toohey 212-339-5690 /s/ Alexandra Toohey New York NY 08-14-2023 0 107 17279240811 INFORMATION TABLE 2 infotable.xml 2seventy bio, Inc. COMMON STOCK 901384107 25274963 2497526 SH SOLE 2497526 0 0 Aadi Bioscience, Inc. COM 00032Q104 6771108 989928 SH SOLE 989928 0 0 AbCellera Biologics Inc. COM 00288U106 106268163 16450180 SH SOLE 16450180 0 0 ACADIA Pharmaceuticals Inc. COM 004225108 1026607457 42864612 SH SOLE 42864612 0 0 Achilles Therapeutics plc SPONSORED ADS 00449L102 2417017 2557149 SH SOLE 2557149 0 0 Adaptimmune Therapeutics plc SPONSORED ADR 00653A107 10146586 10969282 SH SOLE 10969282 0 0 Aeglea BioTherapeutics, Inc. COM 00773J103 1536253 3410106 SH SOLE 3410106 0 0 Aerovate Therapeutics, Inc. COM 008064107 33673665 1963479 SH SOLE 1963479 0 0 Affimed N.V. COM N01045108 3946224 6596830 SH SOLE 6596830 0 0 Akero Therapeutics, Inc. COM 00973Y108 110579569 2368378 SH SOLE 2368378 0 0 Alector, Inc. COM 014442107 5798755 964851 SH SOLE 964851 0 0 Aligos Therapeutics, Inc. COM 01626L105 2016184 2076400 SH SOLE 2076400 0 0 Allogene Therapeutics, Inc. COM 019770106 7837198 1576901 SH SOLE 1576901 0 0 AnaptysBio, Inc. COM 032724106 15782294 775924 SH SOLE 775924 0 0 Aravive, Inc. COM 03890D108 4109142 3261224 SH SOLE 3261224 0 0 argenx SE SPONSORED ADR 04016X101 109186367 280159 SH SOLE 280159 0 0 ARS Pharmaceuticals, Inc. COM 82835W108 13443222 2006451 SH SOLE 2006451 0 0 Athira Pharma, Inc. COM 04746L104 9303731 3153807 SH SOLE 3153807 0 0 Atreca, Inc. CL A COM 04965G109 3462105 3532760 SH SOLE 3532760 0 0 Avidity Biosciences, Inc. COM 05370A108 8865912 799451 SH SOLE 799451 0 0 BeiGene, Ltd. SPONSORED ADR 07725L102 2080564335 11668897 SH SOLE 11668897 0 0 Bicycle Therapeutics plc SPONSORED ADS 088786108 21534133 843814 SH SOLE 843814 0 0 BioCryst Pharmaceuticals, Inc. COM 09058V103 89484159 12710818 SH SOLE 12710818 0 0 BioMarin Pharmaceutical Inc. COM 09061G101 330272297 3810248 SH SOLE 3810248 0 0 Biomea Fusion, Inc. COM 09077A106 46291431 2108949 SH SOLE 2108949 0 0 bluebird bio, Inc. COM 09609G100 8224062 2499715 SH SOLE 2499715 0 0 Cabaletta Bio, Inc. COM 12674W109 20578540 1594000 SH SOLE 1594000 0 0 Century Therapeutics, Inc. COM 15673T100 3631914 1149340 SH SOLE 1149340 0 0 Cerus Corporation COM 157085101 39526193 16067558 SH SOLE 16067558 0 0 Chinook Therapeutics, Inc. COM 16961L106 55908861 1455202 SH SOLE 1455202 0 0 Cogent Biosciences, Inc. COM 19240Q201 11598464 979600 SH SOLE 979600 0 0 Compass Therapeutics, Inc. COM 20454B104 4953263 1557630 SH SOLE 1557630 0 0 Day One Biopharmaceuticals, Inc. COM 23954D109 11940000 1000000 SH SOLE 1000000 0 0 DBV Technologies S.A. SPONSORED ADR 23306J101 27767102 14614264 SH SOLE 14614264 0 0 Denali Therapeutics Inc. COM 24823R105 42946552 1455322 SH SOLE 1455322 0 0 Design Therapeutics, Inc. COM 25056L103 3150000 500000 SH SOLE 500000 0 0 DICE Therapeutics, Inc. COM 23345J104 48122618 1035786 SH SOLE 1035786 0 0 Edgewise Therapeutics, Inc. COM 28036F105 3875000 500000 SH SOLE 500000 0 0 Entrada Therapeutics, Inc. COM 29384C108 73668500 4865819 SH SOLE 4865819 0 0 Fate Therapeutics, Inc. COM 31189P102 7957373 1671717 SH SOLE 1671717 0 0 FibroGen, Inc. COM 31572Q808 642827 238084 SH SOLE 238084 0 0 Foghorn Therapeutics Inc. COM 344174107 316990 45027 SH SOLE 45027 0 0 Genetron Holdings Limited ADS 37186H100 423480 455306 SH SOLE 455306 0 0 Geron Corporation COM 374163103 9826529 3061224 SH SOLE 3061224 0 0 Gracell Biotechnologies Inc. SPONSORED ADS 38406L103 3810000 1000000 SH SOLE 1000000 0 0 Heron Therapeutics, Inc. COM 427746102 9432746 8131678 SH SOLE 8131678 0 0 HOOKIPA Pharma Inc. COM 43906K100 3894471 4425535 SH SOLE 4425535 0 0 IDEAYA Biosciences, Inc. COM 45166A102 24959891 1062123 SH SOLE 1062123 0 0 IGM Biosciences, Inc. COM 449585108 29141048 3157210 SH SOLE 3157210 0 0 Immatics N.V. SHS N44445109 65095017 5640816 SH SOLE 5640816 0 0 Immunocore Holdings plc ADS 45258D105 151143031 2520731 SH SOLE 2520731 0 0 ImmunoGen, Inc. COM 45253H101 28684230 1520097 SH SOLE 1520097 0 0 Incyte Corporation COM 45337C102 2252083986 36178056 SH SOLE 36178056 0 0 Insmed Incorporated COM PAR $.01 457669307 7237300 343000 SH SOLE 343000 0 0 Instil Bio, Inc. COM 45783C101 2905858 5273789 SH SOLE 5273789 0 0 Invitae Corporation COM 46185L103 10035648 8881104 SH SOLE 8881104 0 0 iTeos Therapeutics, Inc. COM 46565G104 1990581 150346 SH SOLE 150346 0 0 Kala Pharmaceuticals, Inc. COM 483119202 1695548 116213 SH SOLE 116213 0 0 Kiniksa Pharmaceuticals, Ltd. COM CL A G5269C101 39558844 2809577 SH SOLE 2809577 0 0 Kodiak Sciences Inc. COM 50015M109 119442381 17310490 SH SOLE 17310490 0 0 Krystal Biotech, Inc. COM 501147102 19950252 169934 SH SOLE 169934 0 0 Kymera Therapeutics, Inc. COM 501575104 100589067 4375340 SH SOLE 4375340 0 0 Leap Therapeutics, Inc. COM 52187K200 3668908 1172175 SH SOLE 1172175 0 0 MacroGenics, Inc. COM 556099109 4775298 892579 SH SOLE 892579 0 0 Madrigal Pharmaceuticals, Inc. COM 558868105 356921103 1545113 SH SOLE 1545113 0 0 Mereo BioPharma Group PLC SPONSORED ADS 589492107 4692572 3554979 SH SOLE 3554979 0 0 Mersana Therapeutics, Inc. COM 59045L106 3573318 1086115 SH SOLE 1086115 0 0 Mirati Therapeutics, Inc. COM 60468T105 50935496 1409784 SH SOLE 1409784 0 0 Monte Rosa Therapeutics, Inc. COM 61225M102 20714064 3023951 SH SOLE 3023951 0 0 Natera, Inc. COM 632307104 4866000 100000 SH SOLE 100000 0 0 Neoleukin Therapeutics, Inc. COM 64049K104 3172044 3821740 SH SOLE 3821740 0 0 Nkarta, Inc. COM 65487U108 594211 271329 SH SOLE 271329 0 0 Nurix Therapeutics, Inc. COM 67080M103 38782429 3882125 SH SOLE 3882125 0 0 Opthea Limited SPONSORED ADS 68386J208 7535895 2691391 SH SOLE 2691391 0 0 Pacific Biosciences of California, Inc. COM 69404D108 14999501 1127782 SH SOLE 1127782 0 0 Perspective Therapeutics, Inc. COM 46489V104 1549283 2319286 SH SOLE 2319286 0 0 PMV Pharmaceuticals, Inc. COM 69353Y103 2015870 322024 SH SOLE 322024 0 0 POINT Biopharma Global Inc. COM 730541109 10592073 1169103 SH SOLE 1169103 0 0 Praxis Precision Medicines, Inc. COM 74006W108 2161902 1879915 SH SOLE 1879915 0 0 Prelude Therapeutics Inc. COM 74065P101 45557208 10123824 SH SOLE 10123824 0 0 Prime Medicine, Inc. COM 74168J101 15067027 1028466 SH SOLE 1028466 0 0 Protara Therapeutics, Inc. COM STK 74365U107 477214 199671 SH SOLE 199671 0 0 Relay Therapeutics, Inc. COM 75943R102 14571070 1160117 SH SOLE 1160117 0 0 Replimune Group, Inc. COM 76029N106 106307662 4578280 SH SOLE 4578280 0 0 Revolution Medicines, Inc. COM 76155X100 71997438 2691493 SH SOLE 2691493 0 0 Rhythm Pharmaceuticals, Inc. COM 76243J105 107156423 6498267 SH SOLE 6498267 0 0 Roivant Sciences Ltd. SHS G76279101 95040207 9428592 SH SOLE 9428592 0 0 Sana Biotechnology, Inc. COM 799566104 11920000 2000000 SH SOLE 2000000 0 0 Seagen Inc. COM 81181C104 8574894019 44554162 SH SOLE 44554162 0 0 Sera Prognostics, Inc. CLASS A COM 81749D107 5856648 1777435 SH SOLE 1777435 0 0 SpringWorks Therapeutics, Inc. COM 85205L107 78655962 2999846 SH SOLE 2999846 0 0 Stoke Therapeutics, Inc. COM 86150R107 22644430 2130238 SH SOLE 2130238 0 0 Summit Therapeutics Inc. COM 86627T108 15824810 6304705 SH SOLE 6304705 0 0 Surrozen, Inc. W EXP 8/11/2026 86889P117 46000 833333 SH SOLE 833333 0 0 Talis Biomedical Corporation COM 87424L207 3659921 7624835 SH SOLE 7624835 0 0 Tango Therapeutics, Inc. COM 87583X109 2490000 750000 SH SOLE 750000 0 0 TScan Therapeutics, Inc. COM 89854M101 6961980 2784792 SH SOLE 2784792 0 0 Ultragenyx Pharmaceutical Inc. COM 90400D108 36122512 783059 SH SOLE 783059 0 0 Vaxcyte, Inc. COM 92243G108 2441317 48885 SH SOLE 48885 0 0 Vera Therapeutics, Inc. CL A 92337R101 2350747 146464 SH SOLE 146464 0 0 Verastem, Inc. COM 92337C203 9943448 1336485 SH SOLE 1336485 0 0 Verve Therapeutics, Inc. COM 92539P101 26559938 1416530 SH SOLE 1416530 0 0 Vincerx Pharma, Inc. COM 92731L106 293253 225579 SH SOLE 225579 0 0 Vor Biopharma Inc. COM 929033108 1958590 633848 SH SOLE 633848 0 0 Xencor, Inc. COM 98401F105 3074481 123127 SH SOLE 123127 0 0 Xenon Pharmaceuticals Inc. COM 98420N105 28938102 751639 SH SOLE 751639 0 0 Invitae Corporation Note 1.5% 4/1/2028 46185LAD5 135000000 300000000 PRN SOLE 300000000 0 0