Chief Financial Officer

0001104659-22-061288.txt : 20220516 0001104659-22-061288.hdr.sgml : 20220516 20220516160542 ACCESSION NUMBER: 0001104659-22-061288 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20220331 FILED AS OF DATE: 20220516 DATE AS OF CHANGE: 20220516 EFFECTIVENESS DATE: 20220516 FILER: COMPANY DATA: COMPANY CONFORMED NAME: BAKER BROS. ADVISORS LP CENTRAL INDEX KEY: 0001263508 IRS NUMBER: 134093645 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-10519 FILM NUMBER: 22928780 BUSINESS ADDRESS: STREET 1: 860 WASHINGTON STREET STREET 2: 3RD FLOOR CITY: NEW YORK STATE: NY ZIP: 10014 BUSINESS PHONE: 2123395600 MAIL ADDRESS: STREET 1: 860 WASHINGTON STREET STREET 2: 3RD FLOOR CITY: NEW YORK STATE: NY ZIP: 10014 FORMER COMPANY: FORMER CONFORMED NAME: BAKER BROS ADVISORS LLC DATE OF NAME CHANGE: 20030911 13F-HR 1 primary_doc.xml 13F-HR LIVE false false false 0001263508 XXXXXXXX 03-31-2022 03-31-2022 false BAKER BROS. ADVISORS LP

860 WASHINGTON STREET 3RD FLOOR NEW YORK NY 10014

13F HOLDINGS REPORT 028-10519 N Alexandra Toohey Chief Financial Officer 212-339-5690 /s/ Alexandra Toohey New York NY 05-16-2022 0 118 17403462 INFORMATION TABLE 2 infotable.xml 2seventy bio, Inc. COMMON STOCK 901384107 35190 2062744 SH SOLE 2062744 0 0 AbCellera Biologics Inc. COM 00288U106 101889 10450180 SH SOLE 10450180 0 0 ACADIA Pharmaceuticals Inc. COM 004225108 1015077 41910704 SH SOLE 41910704 0 0 Achilles Therapeutics plc SPONSORED ADS 00449L102 7619 2591366 SH SOLE 2591366 0 0 Adaptimmune Therapeutics plc SPONSORED ADR 00653A107 20252 9830877 SH SOLE 9830877 0 0 Aeglea BioTherapeutics, Inc. COM 00773J103 7843 3410106 SH SOLE 3410106 0 0 Aerovate Therapeutics, Inc. COM 008064107 37943 2070010 SH SOLE 2070010 0 0 Affimed N.V. COM N01045108 22519 5153169 SH SOLE 5153169 0 0 Akero Therapeutics, Inc. COM 00973Y108 1680 118378 SH SOLE 118378 0 0 Alector, Inc. COM 014442107 3409 239228 SH SOLE 239228 0 0 Aligos Therapeutics, Inc. COM 01626L105 4464 2076400 SH SOLE 2076400 0 0 Alkermes plc SHS G01767105 39465 1500000 SH SOLE 1500000 0 0 Allakos Inc. COM 01671P100 4007 703050 SH SOLE 703050 0 0 Altimmune, Inc. COM 02155H200 6529 1072038 SH SOLE 1072038 0 0 Amarin Corporation plc SPONSORED ADR 023111206 69649 21169805 SH SOLE 21169805 0 0 AnaptysBio, Inc. COM 032724106 10568 427179 SH SOLE 427179 0 0 argenx SE SPONSORED ADR 04016X101 353008 1119557 SH SOLE 1119557 0 0 Ascendis Pharma A/S SPONSORED ADR 04351P101 533003 4541604 SH SOLE 4541604 0 0 Athira Pharma, Inc. COM 04746L104 10886 806367 SH SOLE 806367 0 0 Atreca, Inc. CL A COM 04965G109 11199 3532760 SH SOLE 3532760 0 0 aTyr Pharma, Inc. COM 002120202 3344 625000 SH SOLE 625000 0 0 Axsome Therapeutics, Inc. COM 05464T104 25288 610970 SH SOLE 610970 0 0 BeiGene, Ltd. SPONSORED ADR 07725L102 2200754 11668897 SH SOLE 11668897 0 0 Bellicum Pharmaceuticals, Inc. COM 079481404 538 249123 SH SOLE 249123 0 0 BioAtla, Inc. COM 09077B104 4125 825000 SH SOLE 825000 0 0 BioCryst Pharmaceuticals, Inc. COM 09058V103 206678 12710818 SH SOLE 12710818 0 0 BioMarin Pharmaceutical Inc. COM 09061G101 587540 7620494 SH SOLE 7620494 0 0 Biomea Fusion, Inc. COM 09077A106 6919 1551445 SH SOLE 1551445 0 0 bluebird bio, Inc. COM 09609G100 12124 2499715 SH SOLE 2499715 0 0 Burning Rock Biotech Limited SPONSORED ADS 12233L107 1943 209131 SH SOLE 209131 0 0 Cabaletta Bio, Inc. COM 12674W109 1344 662063 SH SOLE 662063 0 0 Centessa Pharmaceuticals plc SPONSORED ADS 152309100 10112 1127273 SH SOLE 1127273 0 0 Cerus Corporation COM 157085101 75285 13713195 SH SOLE 13713195 0 0 ChemoCentryx, Inc. COM 16383L106 22986 916862 SH SOLE 916862 0 0 Chinook Therapeutics, Inc. COM 16961L106 38186 2334102 SH SOLE 2334102 0 0 Crinetics Pharmaceuticals, Inc. COM 22663K107 18163 827480 SH SOLE 827480 0 0 CymaBay Therapeutics, Inc. COM 23257D103 6750 2170464 SH SOLE 2170464 0 0 Cyteir Therapeutics, Inc. COM 23284P103 3064 812640 SH SOLE 812640 0 0 DBV Technologies S.A. SPONSORED ADR 23306J101 23237 14614264 SH SOLE 14614264 0 0 Denali Therapeutics Inc. COM 24823R105 2855 88738 SH SOLE 88738 0 0 Design Therapeutics, Inc. COM 25056L103 23202 1436636 SH SOLE 1436636 0 0 DICE Therapeutics, Inc. COM 23345J104 11253 588235 SH SOLE 588235 0 0 Edgewise Therapeutics, Inc. COM 28036F105 4850 500000 SH SOLE 500000 0 0 Entrada Therapeutics, Inc. COM 29384C108 44174 4704419 SH SOLE 4704419 0 0 Epizyme, Inc. COM 29428V104 1150 1000000 SH SOLE 1000000 0 0 FibroGen, Inc. COM 31572Q808 6993 581750 SH SOLE 581750 0 0 Foghorn Therapeutics Inc. COM 344174107 686 45027 SH SOLE 45027 0 0 Forma Therapeutics Holdings, Inc. SHS 34633R104 18831 2024876 SH SOLE 2024876 0 0 Fulgent Genetics, Inc. COM 359664109 12572 201444 SH SOLE 201444 0 0 Genetron Holdings Limited ADS 37186H100 997 455306 SH SOLE 455306 0 0 Global Blood Therapeutics, Inc. COM 37890U108 114823 3314765 SH SOLE 3314765 0 0 Harmony Biosciences Holdings, Inc. COM 413197104 6013 123600 SH SOLE 123600 0 0 Heron Therapeutics, Inc. COM 427746102 46513 8131678 SH SOLE 8131678 0 0 HOOKIPA Pharma Inc. COM 43906K100 5473 2400481 SH SOLE 2400481 0 0 Horizon Therapeutics Public Ltd Co SHS G46188101 94567 898842 SH SOLE 898842 0 0 IGM Biosciences, Inc. COM 449585108 84363 3156102 SH SOLE 3156102 0 0 Immatics N.V. SHS N44445109 35346 4423731 SH SOLE 4423731 0 0 Immunocore Holdings plc ADS 45258D105 75370 2520730 SH SOLE 2520730 0 0 Incyte Corporation COM 45337C102 2871326 36153684 SH SOLE 36153684 0 0 Inozyme Pharma, Inc. COM 45790W108 438 106999 SH SOLE 106999 0 0 Insmed Incorporated COM PAR $.01 457669307 50666 2156001 SH SOLE 2156001 0 0 Instil Bio, Inc. COM 45783C101 41857 3893700 SH SOLE 3893700 0 0 Invitae Corporation COM 46185L103 78692 9873488 SH SOLE 9873488 0 0 Iteos Therapeutics, Inc. COM 46565G104 4838 150346 SH SOLE 150346 0 0 Karuna Therapeutics, Inc. COM 48576A100 8871 69966 SH SOLE 69966 0 0 Kezar Life Sciences, Inc. COM 49372L100 2321 139676 SH SOLE 139676 0 0 Kiniksa Pharmaceuticals, Ltd. COM CL A G5269C101 27828 2799577 SH SOLE 2799577 0 0 Kodiak Sciences Inc. COM 50015M109 122988 15931045 SH SOLE 15931045 0 0 Krystal Biotech, Inc. COM 501147102 53747 807735 SH SOLE 807735 0 0 Kura Oncology, Inc. COM 50127T109 4413 274458 SH SOLE 274458 0 0 Kymera Therapeutics, Inc. COM 501575104 100922 2384742 SH SOLE 2384742 0 0 Leap Therapeutics, Inc. COM 52187K101 979 559705 SH SOLE 559705 0 0 Legend Biotech Corporation SPONSORED ADS 52490G102 73007 2008999 SH SOLE 2008999 0 0 LogicBio Therapeutics, Inc. COM 54142F102 307 451478 SH SOLE 451478 0 0 MacroGenics, Inc. COM 556099109 3899 442579 SH SOLE 442579 0 0 Madrigal Pharmaceuticals, Inc. COM 558868105 147103 1499213 SH SOLE 1499213 0 0 Merus N.V. COM N5749R100 53871 2037469 SH SOLE 2037469 0 0 Mirati Therapeutics, Inc. COM 60468T105 115912 1409784 SH SOLE 1409784 0 0 Neoleukin Therapeutics, Inc. COM 64049K104 7185 3821740 SH SOLE 3821740 0 0 Neurocrine Biosciences, Inc. COM 64125C109 63466 676975 SH SOLE 676975 0 0 NexImmune, Inc. COM 65344D109 1238 294117 SH SOLE 294117 0 0 NGM Biopharmaceuticals, Inc. COM 62921N105 4450 291801 SH SOLE 291801 0 0 Novavax, Inc. COM 670002401 3548 48168 SH SOLE 48168 0 0 Nurix Therapeutics, Inc. COM 67080M103 34382 2454082 SH SOLE 2454082 0 0 Opthea Limited SPONSORED ADS 68386J208 18485 2696191 SH SOLE 2696191 0 0 Otonomy, Inc. COM 68906L105 18827 7844692 SH SOLE 7844692 0 0 Oyster Point Pharma, Inc. COM 69242L106 715 61424 SH SOLE 61424 0 0 Pacific Biosciences of California, Inc. COM 69404D108 49549 5444963 SH SOLE 5444963 0 0 Passage Bio, Inc. COM 702712100 363 117161 SH SOLE 117161 0 0 Prelude Therapeutics Inc. COM 74065P101 69854 10123824 SH SOLE 10123824 0 0 Protara Therapeutics, Inc. COM STK 74365U107 1020 199671 SH SOLE 199671 0 0 Reata Pharmaceuticals, Inc. CL A 75615P103 7337 223976 SH SOLE 223976 0 0 Relmada Therapeutics, Inc. COM 75955J402 13363 495113 SH SOLE 495113 0 0 Replimune Group, Inc. COM 76029N106 27367 1611703 SH SOLE 1611703 0 0 Revolution Medicines, Inc. COM 76155X100 5669 222222 SH SOLE 222222 0 0 Rhythm Pharmaceuticals, Inc. COM 76243J105 47521 4125062 SH SOLE 4125062 0 0 Sarepta Therapeutics, Inc. COM 803607100 9644 123456 SH SOLE 123456 0 0 Seagen Inc. COM 81181C104 6757712 46912266 SH SOLE 46912266 0 0 Sera Prognostics, Inc. CLASS A COM 81749D107 764 201562 SH SOLE 201562 0 0 Surrozen, Inc. COM 86889P109 7525 2500000 SH SOLE 2500000 0 0 Surrozen, Inc. W EXP 8/11/2026 86889P117 208 833333 SH SOLE 833333 0 0 Syndax Pharmaceuticals, Inc. COM 87164F105 1924 110729 SH SOLE 110729 0 0 Talis Biomedical Corporation COM 87424L108 10751 7624835 SH SOLE 7624835 0 0 Tango Therapeutics, Inc. COM 87583X109 5685 750000 SH SOLE 750000 0 0 TCR2 Therapeutics Inc. COM 87808K106 2078 753064 SH SOLE 753064 0 0 Travere Therapeutics, Inc. COM 89422G107 85041 3300009 SH SOLE 3300009 0 0 Tricida, Inc. COM 89610F101 14235 1731714 SH SOLE 1731714 0 0 TScan Therapeutics, Inc. COM 89854M101 3990 1425000 SH SOLE 1425000 0 0 Ultragenyx Pharmaceutical Inc. COM 90400D108 32276 444444 SH SOLE 444444 0 0 Vera Therapeutics, Inc. CL A 92337R101 7830 333333 SH SOLE 333333 0 0 Verastem, Inc. COM 92337C104 38054 26988898 SH SOLE 26988898 0 0 Verve Therapeutics, Inc. COM 92539P101 32325 1416530 SH SOLE 1416530 0 0 Vincerx Pharma, Inc. COM 92731L106 966 241379 SH SOLE 241379 0 0 Xenon Pharmaceuticals Inc. COM 98420N105 22978 751639 SH SOLE 751639 0 0 Zymeworks Inc. COM 98985W102 11190 1708472 SH SOLE 1708472 0 0 Insmed Incorporated Note 0.75% 6/1/2028 457669AB5 38614 40000000 PRN SOLE 40000000 0 0 Invitae Corporation Note 2.0% 9/1/2024 46185LAB9 8379 10300000 PRN SOLE 10300000 0 0 Sarepta Therapeutics, Inc. DBCV 1.5% 11/15/2024 803607AB6 38359 29174000 PRN SOLE 29174000 0 0