GTx, Inc.
Computation of Deficiency of Earnings Available to Cover Fixed Charges	Exhibit 12.1

	Three Months Ended			Year Ended December 31,
	3/31/2009			2008			2007			2006			2005			2004
Loss:
Pretax loss from continuing operations	$	(11,301	)	$	(51,780	)	$	(40,359	)	$	(35,510	)	$	(36,839	)	$	(22,348	)
Fixed charges (from below)		25			89			35			32			32			21
Total loss	$	(11,276	)	$	(51,691	)	$	(40,324	)	$	(35,478	)	$	(36,807	)	$	(22,327	)
Fixed charges:
Estimated interest portion of rent expenses	$	25		$	89		$	35		$	32		$	32		$	21
Total fixed charges	$	25		$	89		$	35		$	32		$	32		$	21
Coverage deficiency	$	(11,301	)	$	(51,780	)	$	(40,359	)	$	(35,510	)	$	(36,839	)	$	(22,348	)