GTx, Inc.
Computation of Deficiency of Earnings Available to Cover Fixed Charges Exhibit 12.1

	Six Months Ended			Year Ended December 31,
	6/30/2008			2007			2006			2005			2004			2003
Loss:
Pretax loss from continuing operations	$	(25,986	)	$	(40,359	)	$	(35,510	)	$	(36,839	)	$	(22,348	)	$	(14,194	)
Fixed charges (from below)		40			35			32			32			21			18
Total loss	$	(25,946	)	$	(40,324	)	$	(35,478	)	$	(36,807	)	$	(22,327	)	$	(14,176	)
Fixed charges:
Estimated interest portion of rent expenses	$	40		$	35		$	32		$	32		$	21		$	18
Total fixed charges	$	40		$	35		$	32		$	32		$	21		$	18
Coverage deficiency	$	(25,986	)	$	(40,359	)	$	(35,510	)	$	(36,839	)	$	(22,348	)	$	(14,194	)