GTx, Inc.
Computation of Deficiency of Earnings Available to Cover Fixed Charges	Exhibit 12.1

	Three Months Ended			Year Ended December 31,
	March 31, 2008			2007			2006			2005			2004			2003
Loss:
Pretax loss from continuing operations	$	(12,743	)	$	(40,359	)	$	(35,510	)	$	(36,839	)	$	(22,348	)	$	(14,194	)
Fixed charges (from below)		20			35			32			32			21			18
Total loss	$	(12,723	)	$	(40,324	)	$	(35,478	)	$	(36,807	)	$	(22,327	)	$	(14,176	)
Fixed charges:
Estimated interest portion of rent expenses	$	20		$	35		$	32		$	32		$	21		$	18
Total fixed charges	$	20		$	35		$	32		$	32		$	21		$	18
Coverage deficiency	$	(12,743	)	$	(40,359	)	$	(35,510	)	$	(36,839	)	$	(22,348	)	$	(14,194	)