Exhibit 12.1

GTx, Inc.
Computation of Deficiency of Earnings Available to Cover Fixed Charges

	Nine Months Ended			Year Ended December 31,
	September 30, 2009			2008			2007			2006			2005			2004
Loss:
Pretax loss from continuing operations	$	(35,381	)	$	(51,780	)	$	(40,359	)	$	(35,510	)	$	(36,839	)	$	(22,348	)
Fixed charges (from below)		77			89			35			32			32			21
Total loss	$	(35,304	)	$	(51,691	)	$	(40,324	)	$	(35,478	)	$	(36,807	)	$	(22,327	)
Fixed charges:
Estimated interest portion of rent expenses	$	77		$	89		$	35		$	32		$	32		$	21
Total fixed charges	$	77		$	89		$	35		$	32		$	32		$	21
Coverage deficiency	$	(35,381	)	$	(51,780	)	$	(40,359	)	$	(35,510	)	$	(36,839	)	$	(22,348	)