The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
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COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
3M CO COM 88579Y101   80,199 763 SH   SOLE   763 0 0
908 DEVICES INC COM 65443P102   7,528,844 875,447 SH   SOLE   846,818 0 28,629
ABSCI CORPORATION COM 00091E109   1,017,667 581,524 SH   SOLE   581,524 0 0
AC IMMUNE SA SHS H00263105   2,532,961 1,082,462 SH   SOLE   1,082,462 0 0
ADAPTIVE BIOTECHNOLOGIES COR COM 00650F109   3,233,811 366,230 SH   SOLE   366,230 0 0
ALECTOR INC COM 014442107   1,124,655 181,689 SH   SOLE   181,689 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102   90,934,274 889,942 SH   SOLE   812,710 0 77,232
ALLAKOS INC COM 01671P100   2,825,852 635,023 SH   SOLE   635,023 0 0
ALLISON TRANSMISSION HLDGS I COM 01973R101   190,279 4,206 SH   SOLE   4,206 0 0
ALLY FINL INC COM 02005N100   16,401,795 643,460 SH   SOLE   643,460 0 0
ALPHA TEKNOVA INC COM 02080L102   915,167 309,178 SH   SOLE   309,178 0 0
ALPHABET INC CAP STK CL A 02079K305   12,453,928 120,061 SH   SOLE   120,061 0 0
ALPHABET INC CAP STK CL C 02079K107   36,224,032 348,308 SH   SOLE   348,308 0 0
ALTIMMUNE INC COM NEW 02155H200   401,242 95,081 SH   SOLE   95,081 0 0
ANALOG DEVICES INC COM 032654105   1,447,003 7,337 SH   SOLE   7,337 0 0
APPLIED MATLS INC COM 038222105   2,613,331 21,276 SH   SOLE   21,276 0 0
ARCUS BIOSCIENCES INC COM 03969F109   4,242,843 232,612 SH   SOLE   232,612 0 0
ARROWHEAD PHARMACEUTICALS IN COM 04280A100   1,935,683 76,208 SH   SOLE   76,208 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108   748,575 890,736 SH   SOLE   890,736 0 0
AT&T INC COM 00206R102   87,087 4,524 SH   SOLE   4,524 0 0
BALL CORP COM 058498106   204,899 3,718 SH   SOLE   3,718 0 0
BAXTER INTL INC COM 071813109   87,528 2,158 SH   SOLE   2,158 0 0
BEST BUY INC COM 086516101   90,324 1,154 SH   SOLE   1,154 0 0
BIO RAD LABS INC CL A 090572207   8,786,185 18,342 SH   SOLE   18,342 0 0
BIOGEN INC COM 09062X103   5,702,673 20,511 SH   SOLE   20,511 0 0
BIONTECH SE SPONSORED ADS 09075V102   7,890,015 63,338 SH   SOLE   63,338 0 0
BLACK KNIGHT INC COM 09215C105   1,180,671 20,512 SH   SOLE   20,512 0 0
BLOCK INC CL A 852234103   15,975,267 232,706 SH   SOLE   232,706 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109   2,527,133 56,171 SH   SOLE   56,171 0 0
BOOKING HOLDINGS INC COM 09857L108   28,240,209 10,647 SH   SOLE   10,647 0 0
CALIFORNIA RES CORP COM STOCK 13057Q305   79,118 2,055 SH   SOLE   2,055 0 0
CAMECO CORP COM 13321L108   31,507,179 1,204,061 SH   SOLE   1,204,061 0 0
CAPRI HOLDINGS LIMITED SHS G1890L107   98,888 2,104 SH   SOLE   2,104 0 0
CARLISLE COS INC COM 142339100   55,738,689 246,555 SH   SOLE   212,658 0 33,897
CENTOGENE N V COM N1976T109   1,554,418 2,377,150 SH   SOLE   2,377,150 0 0
CF INDS HLDGS INC COM 125269100   1,457,629 20,108 SH   SOLE   20,108 0 0
CHARTER COMMUNICATIONS INC N CL A 16119P108   133,389 373 SH   SOLE   373 0 0
CIENA CORP COM NEW 171779309   3,765,316 71,693 SH   SOLE   71,693 0 0
CISCO SYS INC COM 17275R102   557,774 10,670 SH   SOLE   10,670 0 0
COGENT BIOSCIENCES INC COM 19240Q201   5,147,693 477,080 SH   SOLE   452,247 0 24,833
COGNIZANT TECHNOLOGY SOLUTIO CL A 192446102   85,485 1,403 SH   SOLE   1,403 0 0
COHERUS BIOSCIENCES INC COM 19249H103   3,761,309 549,899 SH   SOLE   549,899 0 0
CORE LABORATORIES N V COM N22717107   144,317 6,545 SH   SOLE   6,545 0 0
CROWN HLDGS INC COM 228368106   268,890 3,251 SH   SOLE   3,251 0 0
DENALI THERAPEUTICS INC COM 24823R105   1,275,057 55,341 SH   SOLE   55,341 0 0
DINGDONG CAYMAN LTD ADS 25445D101   35,172,335 9,112,004 SH   SOLE   8,971,735 0 140,269
DOORDASH INC CL A 25809K105   13,465,186 211,850 SH   SOLE   211,850 0 0
EBAY INC. COM 278642103   754,689 17,009 SH   SOLE   17,009 0 0
ERICSSON ADR B SEK 10 294821608   2,361,516 403,678 SH   SOLE   403,678 0 0
ESPERION THERAPEUTICS INC NE COM 29664W105   4,103,114 2,580,575 SH   SOLE   2,310,259 0 270,316
EXSCIENTIA PLC ADS 30223G102   21,126,971 3,986,221 SH   SOLE   3,950,064 0 36,157
FOX CORP CL A COM 35137L105   45,082 1,324 SH   SOLE   1,324 0 0
FREEPORT-MCMORAN INC CL B 35671D857   32,906,613 804,366 SH   SOLE   604,290 0 200,076
FULL TRUCK ALLIANCE CO LTD SPONSORED ADS 35969L108   1,515,083 199,091 SH   SOLE   199,091 0 0
GE HEALTHCARE TECHNOLOGIES I COMMON STOCK 36266G107   23,943,983 291,893 SH   SOLE   194,369 0 97,524
GENERAL ELECTRIC CO COM NEW 369604301   73,670,890 770,616 SH   SOLE   509,194 0 261,422
GILEAD SCIENCES INC COM 375558103   61,171,209 737,269 SH   SOLE   516,648 0 220,621
GOSSAMER BIO INC COM 38341P102   2,977,594 2,363,170 SH   SOLE   2,363,170 0 0
H WORLD GROUP LTD SPONSORED ADS 44332N106   46,488,485 949,132 SH   SOLE   949,132 0 0
HANESBRANDS INC COM 410345102   96,884 18,419 SH   SOLE   18,419 0 0
HARMONY BIOSCIENCES HLDGS IN COM 413197104   42,935 1,315 SH   SOLE   1,315 0 0
HELLO GROUP INC ADS 423403104   42,979 4,723 SH   SOLE   4,723 0 0
HENRY JACK & ASSOC INC COM 426281101   58,027 385 SH   SOLE   385 0 0
HERBALIFE NUTRITION LTD COM SHS G4412G101   79,164 4,917 SH   SOLE   4,917 0 0
HUTCHMED CHINA LTD SPONSORED ADS 44842L103   2,370,317 182,052 SH   SOLE   182,052 0 0
ICOSAVAX INC COM 45114M109   14,209,432 2,449,902 SH   SOLE   2,295,372 0 154,530
IDEAYA BIOSCIENCES INC COM 45166A102   11,471,703 835,521 SH   SOLE   730,586 0 104,935
IMMATICS N.V SHS N44445109   1,850,656 268,211 SH   SOLE   268,211 0 0
IMMUNOVANT INC COM 45258J102   5,381,505 346,970 SH   SOLE   346,970 0 0
INHIBRX INC COM 45720L107   4,193,084 222,209 SH   SOLE   222,209 0 0
INTEL CORP COM 458140100   302,982 9,274 SH   SOLE   9,274 0 0
INTERCONTINENTAL EXCHANGE IN COM 45866F104   144,359,157 1,384,209 SH   SOLE   1,072,235 0 311,974
IRIS ENERGY LTD ORDINARY SHARES Q4982L109   8,371,487 2,735,780 SH   SOLE   2,370,652 0 365,128
JACKSON FINANCIAL INC COM CL A 46817M107   94,834 2,535 SH   SOLE   2,535 0 0
JAZZ PHARMACEUTICALS PLC SHS USD G50871105   90,139 616 SH   SOLE   616 0 0
JD.COM INC SPON ADR CL A 47215P106   22,482,609 512,249 SH   SOLE   512,249 0 0
KOHLS CORP COM 500255104   96,137 4,084 SH   SOLE   4,084 0 0
KYNDRYL HLDGS INC COMMON STOCK 50155Q100   3,557 241 SH   SOLE   241 0 0
LAM RESEARCH CORP COM 512807108   7,724,909 14,572 SH   SOLE   14,572 0 0
LEAP THERAPEUTICS INC COM 52187K101   89,900 264,413 SH   SOLE   264,413 0 0
LGI HOMES INC COM 50187T106   32,369,468 283,868 SH   SOLE   283,868 0 0
LIBERTY MEDIA CORP DEL COM SER C FRMLA 531229854   1,144,899 15,300 SH   SOLE   15,300 0 0
LUFAX HOLDING LTD ADS REP SHS CL A 54975P102   37,022 18,148 SH   SOLE   18,148 0 0
MATCH GROUP INC NEW COM 57667L107   4,139,440 107,826 SH   SOLE   107,826 0 0
MERSANA THERAPEUTICS INC COM 59045L106   1,193,125 290,298 SH   SOLE   290,298 0 0
MERUS N V COM N5749R100   4,398,557 239,052 SH   SOLE   239,052 0 0
META PLATFORMS INC CL A 30303M102   58,111,617 274,189 SH   SOLE   274,189 0 0
MICROCHIP TECHNOLOGY INC. COM 595017104   277,871,199 3,316,677 SH   SOLE   2,812,942 0 503,735
MICRON TECHNOLOGY INC COM 595112103   157,634,207 2,612,433 SH   SOLE   2,244,418 0 368,015
MICROSOFT CORP COM 594918104   5,928,601 20,564 SH   SOLE   20,564 0 0
MOBILEYE GLOBAL INC COMMON CLASS A 60741F104   38,856 898 SH   SOLE   898 0 0
MODERNA INC COM 60770K107   5,855,391 38,126 SH   SOLE   38,126 0 0
MOSAIC CO NEW COM 61945C103   2,597,817 56,622 SH   SOLE   56,622 0 0
NANOSTRING TECHNOLOGIES INC COM 63009R109   12,175,050 1,229,803 SH   SOLE   1,198,684 0 31,119
NETFLIX INC COM 64110L106   6,963,149 20,155 SH   SOLE   20,155 0 0
NEW YORK CMNTY BANCORP INC COM 649445103   125,439 13,876 SH   SOLE   13,876 0 0
NOAH HLDGS LTD SPON ADS CL A 65487X102   43,270,753 2,614,547 SH   SOLE   2,614,547 0 0
NXP SEMICONDUCTORS N V COM N6596X109   60,449,228 324,168 SH   SOLE   275,972 0 48,196
OMEGA THERAPEUTICS INC COMMON STOCK 68217N105   5,567,445 923,291 SH   SOLE   896,490 0 26,801
ONEMAIN HLDGS INC COM 68268W103   96,890 2,613 SH   SOLE   2,613 0 0
ORACLE CORP COM 68389X105   1,637,994 17,628 SH   SOLE   17,628 0 0
ORCHARD THERAPEUTICS PLC SPON ADS NEW 68570P200   639,717 119,128 SH   SOLE   119,128 0 0
PARDES BIOSCIENCES INC COM 69945Q105   1,347,069 1,020,507 SH   SOLE   1,020,507 0 0
PAYPAL HLDGS INC COM 70450Y103   1,626,407 21,417 SH   SOLE   21,417 0 0
PDD HOLDINGS INC SPONSORED ADS 722304102   28,054,765 369,628 SH   SOLE   369,628 0 0
PETROLEO BRASILEIRO SA PETRO SPONSORED ADR 71654V408   15,055,444 1,443,475 SH   SOLE   982,306 0 461,169
PIERIS PHARMACEUTICALS INC COM 720795103   951,612 975,012 SH   SOLE   975,012 0 0
PLANET FITNESS INC CL A 72703H101   14,086,076 181,358 SH   SOLE   181,358 0 0
PROMETHEUS BIOSCIENCES INC COM 74349U108   24,846,834 231,521 SH   SOLE   189,978 0 41,543
PROTHENA CORP PLC SHS G72800108   2,011,893 41,508 SH   SOLE   41,508 0 0
QUANTERIX CORP COM 74766Q101   11,336,155 1,005,870 SH   SOLE   959,897 0 45,973
RALPH LAUREN CORP CL A 751212101   98,236 842 SH   SOLE   842 0 0
RECURSION PHARMACEUTICALS IN CL A 75629V104   18,478,908 2,770,451 SH   SOLE   2,725,157 0 45,294
ROBLOX CORP CL A 771049103   4,349,431 96,697 SH   SOLE   96,697 0 0
ROIVANT SCIENCES LTD SHS G76279101   4,594,626 622,578 SH   SOLE   622,578 0 0
RYANAIR HOLDINGS PLC SPONSORED ADS 783513203   942,900 10,000 SH   SOLE   10,000 0 0
SAGE THERAPEUTICS INC COM 78667J108   3,185,603 75,920 SH   SOLE   75,920 0 0
SAREPTA THERAPEUTICS INC COM 803607100   1,382,986 10,034 SH   SOLE   10,034 0 0
SCHLUMBERGER LTD COM STK 806857108   105,505,196 2,148,782 SH   SOLE   1,830,699 0 318,083
SCORPIO TANKERS INC SHS Y7542C130   61,343,495 1,089,389 SH   SOLE   885,423 0 203,966
SILVERCREST METALS INC COM 828363101   12,464,269 1,745,696 SH   SOLE   1,160,649 0 585,047
SINGULAR GENOMICS SYSTEMS IN COM 82933R100   1,066,092 881,068 SH   SOLE   881,068 0 0
SIX FLAGS ENTMT CORP NEW COM 83001A102   3,116,977 116,697 SH   SOLE   116,697 0 0
SKYWORKS SOLUTIONS INC COM 83088M102   1,973,923 16,731 SH   SOLE   16,731 0 0
STRUCTURE THERAPEUTICS INC SPONSORED ADS 86366E106   356,850 15,000 SH   SOLE   15,000 0 0
SUNCOR ENERGY INC NEW COM 867224107   110,464,620 3,563,133 SH   SOLE   3,068,987 0 494,146
SUZANO S A SPON ADS 86959K105   34,882,500 4,248,782 SH   SOLE   4,248,782 0 0
TAL EDUCATION GROUP SPONSORED ADS 874080104   1,450,641 226,309 SH   SOLE   226,309 0 0
THE CIGNA GROUP COM 125523100   73,082 286 SH   SOLE   286 0 0
TORM PLC SHS CL A G89479102   2,778,788 89,264 SH   SOLE   89,264 0 0
TRANSUNION COM 89400J107   122,078,939 1,964,579 SH   SOLE   1,581,226 0 383,353
TRIP COM GROUP LTD ADS 89677Q107   159,805,030 4,242,236 SH   SOLE   3,609,913 0 632,323
TWILIO INC CL A 90138F102   59,367 891 SH   SOLE   891 0 0
TYSON FOODS INC CL A 902494103   87,734 1,479 SH   SOLE   1,479 0 0
ULTA BEAUTY INC COM 90384S303   10,859,379 19,901 SH   SOLE   19,901 0 0
UNIVERSAL HLTH SVCS INC CL B 913903100   92,910 731 SH   SOLE   731 0 0
VALARIS LIMITED CL A G9460G101   50,966,378 783,375 SH   SOLE   664,641 0 118,734
VEEVA SYS INC CL A COM 922475108   467,929 2,546 SH   SOLE   2,546 0 0
VITAL ENERGY INC COM 516806205   38,663 849 SH   SOLE   849 0 0
WARNER BROS DISCOVERY INC COM SER A 934423104   45,647 3,023 SH   SOLE   3,023 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105   1,971,583 455,331 SH   SOLE   455,331 0 0
WESTERN DIGITAL CORP. COM 958102105   2,259,748 59,988 SH   SOLE   59,988 0 0
YUM CHINA HLDGS INC COM 98850P109   5,169,328 81,548 SH   SOLE   81,548 0 0
ZAI LAB LTD ADR 98887Q104   4,482,883 134,783 SH   SOLE   134,783 0 0
ZTO EXPRESS CAYMAN INC SPONSORED ADS A 98980A105   461,114,867 16,089,144 SH   SOLE   13,669,022 0 2,420,122
ZYMEWORKS INC COM 98985Y108   3,673,196 406,327 SH   SOLE   406,327 0 0