-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 PUFYt3N0OUO0U/zfuCWXXsbWrjlwwC8v6fEKAnMm3g8vZ6aNPcoWsbEZCI3EatyJ
 ATg7TcuINeUP1A1RNq4Q+w==

<SEC-DOCUMENT>0001245791-10-000001.txt : 20100107
<SEC-HEADER>0001245791-10-000001.hdr.sgml : 20100107
<ACCEPTANCE-DATETIME>20100106183005
ACCESSION NUMBER:		0001245791-10-000001
CONFORMED SUBMISSION TYPE:	D
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
FILED AS OF DATE:		20100107
DATE AS OF CHANGE:		20100106
EFFECTIVENESS DATE:		20100107

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			GI DYNAMICS, INC.
		CENTRAL INDEX KEY:			0001245791
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		D
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-56377
		FILM NUMBER:		10512990

	BUSINESS ADDRESS:	
		STREET 1:		ONE MAGUIRE ROAD
		CITY:			LEXINGTON
		STATE:			MA
		ZIP:			02421
		BUSINESS PHONE:		781-357-3310

	MAIL ADDRESS:	
		STREET 1:		ONE MAGUIRE ROAD
		CITY:			LEXINGTON
		STATE:			MA
		ZIP:			02421

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	GI DYNAMICS INC
		DATE OF NAME CHANGE:	20030623
</SEC-HEADER>
<DOCUMENT>
<TYPE>D
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0603</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001245791</cik>
        <entityName>GI DYNAMICS, INC.</entityName>
        <issuerAddress>
            <street1>ONE MAGUIRE ROAD</street1>
            <city>LEXINGTON</city>
            <stateOrCountry>MA</stateOrCountry>
            <zipCode>02421</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>781-357-3310</issuerPhoneNumber>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <edgarPreviousNameList>
            <previousName>GI DYNAMICS INC</previousName>
        </edgarPreviousNameList>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Stuart</firstName>
                <middleName>A.</middleName>
                <lastName>Randle</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>One Maguire Road</street1>
                <city>Lexington</city>
                <stateOrCountry>MA</stateOrCountry>
                <zipCode>02421</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Andy</firstName>
                <lastName>Levine</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>One Maguire Road</street1>
                <city>Lexington</city>
                <stateOrCountry>MA</stateOrCountry>
                <zipCode>02421</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Robert</firstName>
                <lastName>Crane</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>One Maguire Road</street1>
                <city>Lexington</city>
                <stateOrCountry>MA</stateOrCountry>
                <zipCode>02421</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Brian</firstName>
                <lastName>Halak</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>1 Palmer Sq.</street1>
                <city>Princeton</city>
                <stateOrCountry>NJ</stateOrCountry>
                <zipCode>08542</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Jack</firstName>
                <lastName>Meyer</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>45 University Ave.</street1>
                <street2>SE #807</street2>
                <city>Minneapolis</city>
                <stateOrCountry>MN</stateOrCountry>
                <zipCode>55414</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Michael</firstName>
                <lastName>Carusi</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>485 Ramona Street</street1>
                <city>Palo Alto</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>64301</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Jonathan</firstName>
                <lastName>Osgood</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>229 Marlborough Street</street1>
                <city>Boston</city>
                <stateOrCountry>MA</stateOrCountry>
                <zipCode>02116</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Kedir</firstName>
                <lastName>Kadhiresan</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o GI Dynamics, Inc.</street1>
                <street2>One Maguire Rd.</street2>
                <city>Lexington</city>
                <stateOrCountry>MA</stateOrCountry>
                <zipCode>02421</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Biotechnology</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2009-12-23</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
            <isOtherType>true</isOtherType>
            <descriptionOfOtherType>Series C Preferred Stock</descriptionOfOtherType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>15000000</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>15000000</totalOfferingAmount>
            <totalAmountSold>15000000</totalAmountSold>
            <totalRemaining>0</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>1</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
                <isEstimate>true</isEstimate>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>GI DYNAMICS, INC.</issuerName>
                <signatureName>Robert Crane</signatureName>
                <nameOfSigner>Robert Crane</nameOfSigner>
                <signatureTitle>Chief Financial Officer</signatureTitle>
                <signatureDate>2010-01-06</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----