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Condensed Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
9 Months Ended
Sep. 30, 2020
Sep. 30, 2019
Cash flows from operating activities:    
Net income $ 49,328 $ 109,681
Adjustments to reconcile net income to net cash provided by operating activities    
Acquired in-process research and development 24,418  
Depreciation and amortization 45,970 38,688
Amortization of premium (discount) on marketable securities 215 (1,008)
Write-down for excess and obsolete inventories 12,411 1,939
Stock-based compensation expense 21,138 19,647
Allowance for doubtful accounts 2,741 2,732
Change in fair value of business acquisition liabilities 1,027 579
Change in deferred income taxes (4,458) 2,434
(Gain)/loss on disposal of assets, net 714 518
Payment of business acquisition related liabilities (700)  
(Increase)/decrease in:    
Accounts receivable 8,412 (5,367)
Inventories (47,271) (40,869)
Prepaid expenses and other assets (4,381) (3,044)
Increase/(decrease) in:    
Accounts payable 5,401 (158)
Accrued expenses and other liabilities 3,749 1,225
Income taxes payable/receivable (105) (9,331)
Net cash provided by operating activities 118,609 117,666
Cash flows from investing activities:    
Purchases of marketable securities (57,418) (277,446)
Maturities of marketable securities 100,830 205,818
Sales of marketable securities 39,944 46,474
Purchases of property and equipment (49,595) (54,957)
Acquisition of businesses, net of cash acquired and purchases of intangible and other assets (31,991) (24,135)
Net cash used in investing activities 1,770 (104,246)
Cash flows from financing activities:    
Payment of business acquisition related liabilities (5,327) (6,096)
Proceeds from exercise of stock options 44,121 19,350
Repurchase of common stock (104,669)  
Net cash used in/provided by financing activities (65,875) 13,254
Effect of foreign exchange rate on cash 379 (231)
Net increase in cash, cash equivalents, and restricted cash 54,883 26,443
Cash, cash equivalents, and restricted cash at beginning of period 195,474 139,647
Cash, cash equivalents, and restricted cash at end of period 250,607 166,190
Supplemental disclosures of cash flow information:    
Income taxes paid 19,328 34,056
Purchases of property and equipment included in accounts payable and accrued expenses $ 3,931 $ 5,959