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Share-Based Compensation - Expense (Details) - USD ($)
$ in Thousands
3 Months Ended 6 Months Ended
Jun. 30, 2024
Jun. 30, 2023
Jun. 30, 2024
Jun. 30, 2023
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]        
Total share-based compensation expense, pre-tax $ 56,654 $ 61,433 $ 118,095 $ 117,785
Income tax benefit from share-based compensation expense (9,629) (11,122) (13,028) (19,741)
Total share-based compensation expense, net of tax 47,025 50,311 105,067 98,044
Selling, general and administrative        
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]        
Total share-based compensation expense, pre-tax 35,137 40,485 75,350 77,887
Research and development        
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]        
Total share-based compensation expense, pre-tax 17,272 17,219 36,103 32,711
Cost of product sales        
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]        
Total share-based compensation expense, pre-tax $ 4,245 $ 3,729 $ 6,642 $ 7,187