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Share-Based Compensation - (Tables)
 6 Months Ended
Jun. 30, 2024
Share-Based Payment Arrangement [Abstract]  
Schedule of Share-Based Compensation Expense Related to Share Options, RSUs , PRSU's and Grants Under ESPP
Share-based compensation expense related to RSUs, PRSUs, grants under our ESPP and share options was as follows (in thousands): 
Three Months Ended
June 30,		Six Months Ended
June 30,
2024202320242023
Selling, general and administrative$35,137 $40,485 $75,350 $77,887 
Research and development17,272 17,219 36,103 32,711 
Cost of product sales4,245 3,729 6,642 7,187 
Total share-based compensation expense, pre-tax56,654 61,433 118,095 117,785 
Income tax benefit from share-based compensation expense(9,629)(11,122)(13,028)(19,741)
Total share-based compensation expense, net of tax$47,025 $50,311 $105,067 $98,044 
Schedule of RSU and PRSU Activity
The table below shows the number of RSUs granted covering an equal number of our ordinary shares and the weighted-average grant date fair value of RSUs granted:
Three Months Ended
June 30,		Six Months Ended
June 30,
2024202320242023
RSUs granted (in thousands)55 66 2,010 1,637 
Grant date fair value$112.00 $132.59 $118.70 $145.65 
The table below shows the number of PRSUs granted covering an equal number of our ordinary shares and the weighted-average grant date fair value of PRSUs granted:
Three Months Ended
June 30,		Six Months Ended
June 30,
2024202320242023
PRSUs granted (in thousands)16 5 313 257 
Grant date fair value$112.60 $139.26 $134.99 $157.72