Insider Trading Arrangements

3 Months Ended

Mar. 31, 2024

shares

Trading Arrangements, by Individual

Non-Rule 10b5-1 Arrangement Adopted

false

Non-Rule 10b5-1 Arrangement Terminated

false

Robert Iannone [Member]

Trading Arrangements, by Individual

Material Terms of Trading Arrangement

The following is a summary of the material terms of the contracts, instructions or written plans for the purchase or sale of the Company’s securities adopted or terminated by our officers (as defined in Rule 16a-1(f) under the Securities Exchange Act of 1934, as amended) and directors during the quarter ended March 31, 2024:

Type of Trading Arrangement

Name and Position	Date	Action	Rule 10b5-1*	Expiration Date	Total Ordinary Shares to be Sold
Robert Iannone	March 7, 2024	Modification	X	March 7, 2025	10,681
Executive Vice President, Global Head of Research and Development

* Contract, instruction or written plan intended to satisfy the affirmative defense conditions of Rule 10b5-1(c) under the Securities Exchange Act of 1934, as amended.

Robert Iannone March 2024 Plan [Member]

Trading Arrangements, by Individual

Rule 10b5-1 Arrangement Adopted

true

Robert Iannone March 2024 Plan [Member] | Robert Iannone [Member]

Trading Arrangements, by Individual

Name

Robert Iannone

Title

Executive Vice President, Global Head of Research and Development

Adoption Date

March 7, 2024

Arrangement Duration

365 days

Aggregate Available

10,681

Robert Iannone, Plan Prior To March 2024 [Member] | Robert Iannone [Member]

Trading Arrangements, by Individual

Rule 10b5-1 Arrangement Terminated

true