Share-Based Compensation - Expense (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]
Total share-based compensation expense, pre-tax	$ 61,433	$ 53,687	$ 117,785	$ 103,757
Income tax benefit from share-based compensation expense	(11,185)	(11,023)	(19,741)	(19,917)
Total share-based compensation expense, net of tax	50,248	42,664	98,044	83,840
Selling, general and administrative
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]
Total share-based compensation expense, pre-tax	40,485	36,233	77,887	71,018
Research and development
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]
Total share-based compensation expense, pre-tax	17,219	14,902	32,711	27,338
Cost of product sales
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]
Total share-based compensation expense, pre-tax	$ 3,729	$ 2,552	$ 7,187	$ 5,401