Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021
Operating activities
Net income (loss)	$ 16,664	$ (294,317)
Adjustments to reconcile net income (loss) to net cash provided by operating activities:
Intangible asset amortization	461,782	368,476
Acquisition accounting inventory fair value step-up adjustment	203,189	148,637
Share-based compensation	160,438	135,887
Deferred tax expense (benefit)	(146,874)	96,593
Impairment charge	133,648	0
Acquired in-process research and development	69,148	0
Loss on disposal of a business	39,258	0
Non-cash interest expense	32,002	66,055
Depreciation	22,958	19,387
Provision for losses on accounts receivable and inventory	13,066	13,444
Other non-cash transactions	(26,352)	9,622
Changes in assets and liabilities:
Accounts receivable	(43,868)	(27,956)
Inventories	(50,458)	(33,891)
Prepaid expenses and other current assets	23,801	(34,722)
Operating lease assets	10,672	12,054
Other non-current assets	(4,006)	(1,837)
Accounts payable	4,188	19,167
Accrued liabilities	17,864	93,534
Income taxes payable	(172)	9,171
Deferred revenue	(1,570)	(1,608)
Operating lease liabilities, less current portion	(12,139)	(13,423)
Other non-current liabilities	6,767	16,479
Net cash provided by operating activities	930,006	600,752
Investing activities
Proceeds from sale of a business	53,000	0
Purchases of property, plant and equipment	(19,668)	(17,674)
Acquisition of intangible assets	(25,000)	(17,891)
Acquisition of investments	(61,036)	(26,694)
Acquired in-process research and development	(69,148)	0
Proceeds from maturity of investments	0	1,095,000
Acquisition of a business, net of cash acquired	0	(6,234,792)
Net cash used in investing activities	(121,852)	(5,202,051)
Financing activities
Proceeds from employee equity incentive and purchase plans	67,863	117,111
Share repurchases	(54)	0
Payment of employee withholding taxes related to share-based awards	(42,632)	(29,603)
Repayments of long-term debt	(574,264)	(843,028)
Net proceeds from issuance of borrowings under credit agreement	0	3,719,930
Net proceeds from issuance of Senior Secured Notes, due 2029	0	1,471,533
Payments for repurchase of Exchangeable Senior Notes, due 2021	0	(218,812)
Net cash (used in) provided by financing activities	(549,087)	4,217,131
Effect of exchange rates on cash and cash equivalents	(11,157)	(1,821)
Net increase (decrease) in cash and cash equivalents	247,910	(385,989)
Cash and cash equivalents, at beginning of period	591,448	1,057,769
Cash and cash equivalents, at end of period	$ 839,358	$ 671,780