Certain Balance Sheet Items

9 Months Ended

Sep. 30, 2022

Property, plant and equipment consisted of the following (in thousands):


	September 30, 2022		December 31, 2021
Manufacturing equipment and machinery	$	67,201	$	69,079
Construction-in-progress	67,088		86,511
Land and buildings	60,720		64,008
Leasehold improvements	60,315		66,318
Computer software	32,876		25,646
Computer equipment	15,769		16,234
Furniture and fixtures	10,341		14,412

Subtotal	314,310		342,208
Less accumulated depreciation and amortization	(97,971)		(85,371)
Property, plant and equipment, net	$	216,339	$	256,837

Other current assets consisted of the following (in thousands):


	September 30, 2022		December 31, 2021
Deferred charge for income taxes on intercompany profit	$	204,652	$	203,480
Other	45,364		48,912
Total other current assets	$	250,016	$	252,392

Accrued liabilities consisted of the following (in thousands):


	September 30, 2022		December 31, 2021
Rebates and other sales deductions	$	266,389	$	215,397
Employee compensation and benefits	152,049		158,870
Derivative instrument liabilities	37,742		18,419
Clinical trial accruals	24,036		25,612
Sales return reserve	22,637		15,814
Consulting and professional services	21,858		22,507
Accrued interest	21,371		48,640
Accrued royalties	20,831		20,345
Current portion of lease liabilities	14,877		15,763
Selling and marketing accruals	13,532		21,566



Inventory-related accruals	6,237		16,166
Accrued construction-in-progress	3,978		2,894

Accrued milestones	750		25,000
Other	62,103		59,311
Total accrued liabilities	$	668,390	$	666,304