Share-Based Compensation - Expense (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2021	Sep. 30, 2020	Sep. 30, 2021	Sep. 30, 2020
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]
Total share-based compensation expense, pre-tax	$ 53,239	$ 30,356	$ 135,887	$ 89,614
Income tax benefit from share-based compensation expense	(10,567)	(3,678)	(25,528)	(10,106)
Total share-based compensation expense, net of tax	42,672	26,678	110,359	79,508
Selling, general and administrative
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]
Total share-based compensation expense, pre-tax	39,117	20,974	97,296	62,590
Research and development
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]
Total share-based compensation expense, pre-tax	11,866	7,463	31,749	21,511
Cost of product sales
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]
Total share-based compensation expense, pre-tax	$ 2,256	$ 1,919	$ 6,842	$ 5,513