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Share-Based Compensation - (Tables)
9 Months Ended
Sep. 30, 2021
Share-based Payment Arrangement [Abstract]  
Schedule of Share-Based Compensation Expense Related to Share Options, RSUs , PRSU's and Grants Under ESPP
Share-based compensation expense related to share options, RSUs, PRSUs and grants under our ESPP was as follows (in thousands): 
Three Months Ended
September 30,
Nine Months Ended
September 30,
2021202020212020
Selling, general and administrative$39,117 $20,974 $97,296 $62,590 
Research and development11,866 7,463 31,749 21,511 
Cost of product sales2,256 1,919 6,842 5,513 
Total share-based compensation expense, pre-tax53,239 30,356 135,887 89,614 
Income tax benefit from share-based compensation expense(10,567)(3,678)(25,528)(10,106)
Total share-based compensation expense, net of tax$42,672 $26,678 $110,359 $79,508 
Schedule of Weighted-Average Assumptions Used in Black-Scholes Option Pricing Model which was Used to Estimate Grant Date Fair Value per Share
The table below shows the number of shares underlying options granted to purchase our ordinary shares, the weighted-average assumptions used in the Black-Scholes option pricing model and the resulting weighted-average grant date fair value of share options granted: 
Three Months Ended
September 30,
Nine Months Ended
September 30,
2021202020212020
Shares underlying options granted (in thousands)— 159 110 803 
Grant date fair value$— $37.75 $51.39 $34.43 
Black-Scholes option pricing model assumption information:
Volatility— %36 %37 %33 %
Expected term (years)— 4.64.54.6
Range of risk-free rates— %
0.2-0.3%
0.4-0.8%
0.2-1.6%
Expected dividend yield— %— %— %— %
The table below shows the number of nominal strike price options granted covering an equal number of our ordinary shares and the weighted-average grant date fair value:
Nine Months Ended
September 30, 2021
Nominal strike price share options granted (in thousands)
124 
Grant date fair value$170.82 
Schedule of RSU and PRSU Activity
The table below shows the number of RSUs granted covering an equal number of our ordinary shares and the weighted-average grant date fair value of RSUs granted:
Three Months Ended
September 30,
Nine Months Ended
September 30,
2021202020212020
RSUs granted (in thousands)75 160 1,707 1,248 
Grant date fair value$161.91 $123.79 $169.69 $114.80 
The table below shows the number of PRSUs granted covering an equal number of our ordinary shares and the weighted-average grant date fair value of PRSUs granted:
Nine Months Ended
September 30, 2021
PRSUs granted (in thousands)224 
Grant date fair value$190.81