Share-Based Compensation - Expense (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2021	Jun. 30, 2020	Jun. 30, 2021	Jun. 30, 2020
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]
Total share-based compensation expense, pre-tax	$ 48,163	$ 30,604	$ 82,648	$ 59,258
Income tax benefit from share-based compensation expense	(8,374)	(3,307)	(14,961)	(6,428)
Total share-based compensation expense, net of tax	39,789	27,297	67,687	52,830
Selling, general and administrative
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]
Total share-based compensation expense, pre-tax	34,333	21,020	58,179	41,616
Research and development
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]
Total share-based compensation expense, pre-tax	11,240	7,663	19,883	14,048
Cost of product sales
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]
Total share-based compensation expense, pre-tax	$ 2,590	$ 1,921	$ 4,586	$ 3,594