Certain Balance Sheet Items

9 Months Ended

Sep. 30, 2020

Property, plant and equipment consisted of the following (in thousands):


	September 30, 2020		December 31, 2019
Leasehold improvements	$	53,670	$	52,294
Land and buildings	47,385		47,053
Manufacturing equipment and machinery	32,077		28,860
Computer software	22,868		25,680
Computer equipment	17,850		16,577
Furniture and fixtures	11,447		11,152
Construction-in-progress	6,072		5,147

Subtotal	191,369		186,763
Less accumulated depreciation and amortization	(63,165)		(55,257)
Property, plant and equipment, net	$	128,204	$	131,506

Accrued liabilities consisted of the following (in thousands):


	September 30, 2020		December 31, 2019
Rebates and other sales deductions	$	113,062	$	96,860
Employee compensation and benefits	76,890		80,531
Sales returns reserve	13,574		3,462
Current portion of operating lease liabilities	13,078		12,728
Royalties	10,186		6,931
Inventory-related accruals	9,318		7,816
Consulting and professional services	8,430		7,665
Derivative instrument liabilities	8,364		1,037
Accrued interest	7,762		7,540
Clinical trial accruals	7,614		3,141
Selling and marketing accruals	7,721		10,946
Accrued collaboration expenses	730		2,494
Accrued construction-in-progress	474		3,015



Other	24,868		25,520
Total accrued liabilities	$	302,071	$	269,686