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Share-Based Compensation
9 Months Ended
Sep. 30, 2018
Disclosure of Compensation Related Costs, Share-based Payments [Abstract]  
Share-Based Compensation
Share-Based Compensation
Share-based compensation expense related to share options, RSUs and grants under our ESPP was as follows (in thousands): 
 
Three Months Ended
September 30,
 
Nine Months Ended
September 30,
 
2018
 
2017
 
2018
 
2017
Selling, general and administrative
$
18,978

 
$
20,903

 
$
57,012

 
$
61,582

Research and development
4,600

 
4,650

 
13,684

 
13,651

Cost of product sales
1,525

 
1,573

 
5,022

 
4,346

Total share-based compensation expense, pre-tax
25,103

 
27,126

 
75,718

 
79,579

Income tax benefit from share-based compensation expense
(3,552
)
 
(6,354
)
 
(12,066
)
 
(23,816
)
Total share-based compensation expense, net of tax
$
21,551

 
$
20,772

 
$
63,652

 
$
55,763


Share Options
The table below shows the number of shares underlying options granted to purchase our ordinary shares, the weighted-average assumptions used in the Black-Scholes option pricing model and the resulting weighted-average grant date fair value of share options granted: 
 
Three Months Ended
September 30,
 
Nine Months Ended
September 30,
 
2018
 
2017
 
2018
 
2017
Shares underlying options granted (in thousands)
117

 
87

 
1,349

 
1,343

Grant date fair value
$
53.93

 
$
45.87

 
$
46.95

 
$
42.69

Black-Scholes option pricing model assumption information:
 
 
 
 
 
 
 
Volatility
32
%
 
35
%
 
35
%
 
35
%
Expected term (years)
4.5

 
4.3

 
4.5

 
4.3

Range of risk-free rates
2.7-2.8%

 
1.6-1.8%

 
2.2-2.8%

 
1.6-1.8%

Expected dividend yield
%
 
%
 
%
 
%

Restricted Stock Units
The table below shows the number of RSUs granted covering an equal number of our ordinary shares and the weighted-average grant date fair value of RSUs granted:
 
Three Months Ended
September 30,
 
Nine Months Ended
September 30,
 
2018
 
2017
 
2018
 
2017
RSUs granted (in thousands)
71

 
35

 
564

 
537

Grant date fair value
$
174.73

 
$
148.60

 
$
145.59

 
$
137.23


The fair value of RSUs is determined on the date of grant based on the market price of our ordinary shares on that date. The fair value of RSUs is expensed ratably over the vesting period, generally over four years.
As of September 30, 2018, compensation cost not yet recognized related to unvested share options and RSUs was $82.8 million and $102.7 million, respectively, which is expected to be recognized over a weighted-average period of 2.7 years and 2.6 years, respectively.