Share-Based Compensation - Expense (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2018	Jun. 30, 2017	Jun. 30, 2018	Jun. 30, 2017
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]
Total share-based compensation expense, pre-tax	$ 26,312	$ 27,260	$ 50,615	$ 52,453
Income tax benefit from share-based compensation expense	(4,846)	(9,838)	(8,514)	(17,462)
Total share-based compensation expense, net of tax	21,466	17,422	42,101	34,991
Selling, general and administrative
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]
Total share-based compensation expense, pre-tax	19,800	20,874	38,034	40,679
Research and development
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]
Total share-based compensation expense, pre-tax	4,709	4,859	9,084	9,001
Cost of product sales
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]
Total share-based compensation expense, pre-tax	$ 1,803	$ 1,527	$ 3,497	$ 2,773