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Certain Balance Sheet Items - Accrued Liabilities (Details) - USD ($)
$ in Thousands
Sep. 30, 2017
Dec. 31, 2016
Certain Balance Sheet Items [Abstract]    
Rebates and other sales deductions $ 76,930 $ 72,344
Employee compensation and benefits 46,672 43,363
Royalties 11,309 11,643
Accrued construction-in-progress 5,488 1,597
Inventory-related accruals 3,843 3,350
Sales returns reserve 3,470 4,366
Professional fees 3,244 4,596
Clinical trial accruals 2,657 10,139
Selling and marketing accruals 2,384 3,924
Accrued interest 2,347 5,179
Accrued contract termination fees 0 11,612
Other 21,546 21,155
Total accrued liabilities $ 179,890 $ 193,268