Share-Based Compensation - Expense (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2017	Jun. 30, 2016	Jun. 30, 2017	Jun. 30, 2016
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]
Total share-based compensation expense, pre-tax	$ 27,260	$ 25,433	$ 52,453	$ 49,616
Income tax benefit from share-based compensation expense	(9,838)	(8,922)	(17,462)	(15,855)
Total share-based compensation expense, net of tax	17,422	16,511	34,991	33,761
Selling, general and administrative
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]
Total share-based compensation expense, pre-tax	20,874	20,949	40,679	41,153
Research and development
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]
Total share-based compensation expense, pre-tax	4,859	3,521	9,001	6,811
Cost of product sales
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]
Total share-based compensation expense, pre-tax	$ 1,527	$ 963	$ 2,773	$ 1,652