Segment and Other Information - Summary of Total Revenues (Details) - USD ($) $ in Thousands	3 Months Ended								12 Months Ended
	Dec. 31, 2016	Sep. 30, 2016	Jun. 30, 2016	Mar. 31, 2016	Dec. 31, 2015	Sep. 30, 2015	Jun. 30, 2015	Mar. 31, 2015	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014
Segment Reporting Information [Line Items]
Product sales, net									$ 1,477,261	$ 1,316,819	$ 1,162,716
Royalties and contract revenues									10,712	7,984	10,159
Total revenues	$ 396,621	$ 374,181	$ 381,161	$ 336,010	$ 340,881	$ 340,872	$ 333,747	$ 309,303	1,487,973	1,324,803	1,172,875
Xyrem
Segment Reporting Information [Line Items]
Product sales, net									1,107,616	955,187	778,584
Erwinaze/Erwinase
Segment Reporting Information [Line Items]
Product sales, net									200,678	203,261	199,665
Defitelio/defibrotide
Segment Reporting Information [Line Items]
Product sales, net									108,952	70,731	70,537
Prialt® (ziconotide) intrathecal infusion
Segment Reporting Information [Line Items]
Product sales, net									29,120	26,440	26,421
Psychiatry
Segment Reporting Information [Line Items]
Product sales, net									17,653	37,135	40,879
Other
Segment Reporting Information [Line Items]
Product sales, net									$ 13,242	$ 24,065	$ 46,630