EXHIBIT 12.1

RATIO OF EARNINGS TO FIXED CHARGES

	Year Ended December 31,
	2008	2007	2006	2005	2004
Ratio of earnings to fixed charges (1)	N/A	N/A	N/A	N/A	N/A

(1) Our earnings were insufficient to cover fixed charges by $184.3 million, $138.8 million, $59.4 million, $85.2 million, $24.8 million and $2.5 million for the years ended December 31, 2008, 2007, 2006, 2005 and 2004, respectively.

JAZZ PHARMACEUTICALS, INC.

COMPUTATION OF RATIOS OF EARNINGS TO FIXED CHARGES

(In thousands)

	Year Ended December 31,
	2008			2007			2006			2005			2004
EARNINGS:
Loss before income taxes		(184,339	)		(138,826	)		(59,391	)		(85,156	)		(24,804	)
Plus: fixed charges (see below)		21,037			14,150			14,458			7,361			109
Less: capitalized interest		—			—			—			—			—
Total loss to cover fixed charges		(163,302	)		(124,676	)		(44,933	)		(77,795	)		(24,695	)
FIXED CHARGES:
Interest expense		17,535			12,256			12,757			6,422			—
Amortization of capitalized expenses and accretion of debt discount related to indebtedness		2,207			1,391			1,372			707			—
Estimated interest portion of rental expense		1,295			503			329			232			109
Total Fixed Charges (1)		21,037			14,150			14,458			7,361			109
DEFICIENCY OF EARNINGS TO COVER FIXED CHARGES	$	(184,339	)	$	(138,826	)	$	(59,391	)	$	(85,156	)	$	(24,804	)

(1) For purposes of computing the ratio of earnings to fixed charges, fixed charges consist of interest expense on long and short term debt, amortization of deferred financing costs, accretion of a debt discount, interest imputed related to a government settlement obligation, interest related to a development financing obligation and a portion of rental expense deemed to be representative of interest.